DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31637 and CHST7

DIOPT Version :9

Sequence 1:	NP_001285677.1	Gene:	CG31637 / 33914	FlyBaseID:	FBgn0051637	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_063939.2	Gene:	CHST7 / 56548	HGNCID:	13817	Length:	486	Species:	Homo sapiens

Alignment Length:	509	Identity:	122/509 - (23%)
Similarity:	185/509 - (36%)	Gaps:	145/509 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LNGKRRRSRMSRRANLIGICGVSSLCILLLIATTQHRPLTTPFNQSAGR--DQGASVDGGPSNSL 113
            :.|:|||.|        ..|..:.|.:|..:..     |..|.....||  |:||....|...||
Human     1 MKGRRRRRR--------EYCKFALLLVLYTLVL-----LLVPSVLDGGRDGDKGAEHCPGLQRSL 52

  Fly   114 A-----RSAFYDRFQ---QQLQQQQQSSQTAVY--NLTATIVDVLSAQRSRILAEMENFEYPRGG 168
            .     .:|..:|.|   .:..::..::|:..:  ||:..:.:.:|.::..|
Human    53 GVWSLEAAAAGEREQGAEARAAEEGGANQSPRFPSNLSGAVGEAVSREKQHI------------- 104

  Fly   169 AERLTDMTPETNGTPVRSVVVTSWRSGSTFLGDILNSIPGNFYHYEPLLDFGIKQIRDPDDQELA 233
                              .|..:||:||:|||::.|..|..||.|||:  :.:.|...|.|.| :
Human   105 ------------------YVHATWRTGSSFLGELFNQHPDVFYLYEPM--WHLWQALYPGDAE-S 148

  Fly   234 VQN-----LKNLLNCDYADMIDYLNFGK-----------THTYLFEHNTRLW----DVCREFPR- 277
            :|.     |::|..||::.:..|...|.           |...||...|...    .:|...||
Human   149 LQGALRDMLRSLFRCDFSVLRLYAPPGDPAARAPDTANLTTAALFRWRTNKVICSPPLCPGAPRA 213

  Fly   278 ----------FCWR--PAFLTRF----CRLFPIQSMKTVR-LRLAQAEKLLEDQSLSSVRIVLLV 325
                      .|.|  |....|.    ||.:|:..:|.|| |.|.....||.|..| ::::|.|.
Human   214 RAEVGLVEDTACERSCPPVAIRALEAECRKYPVVVIKDVRLLDLGVLVPLLRDPGL-NLKVVQLF 277

  Fly   326 RDPRGTMQSRR-----------------------HRVWC--------GGNEDC--EDPR------ 351
            ||||....||.                       |||..        ||....  ..||
Human   278 RDPRAVHNSRLKSRQGLLRESIQVLRTRQRGDRFHRVLLAHGVGARPGGQSRALPAAPRADFFLT 342

  Fly   352 ----LVCQDLRDDYKTAEVLLLKYPSRFRTVRYEDLSLSPSEMTQDILQFYGLPFDPAVEEFLDT 412
                ::|:....|...|.........|:..:|||||...|....:.:|:|.||....|::.|...
Human   343 GALEVICEAWLRDLLFARGAPAWLRRRYLRLRYEDLVRQPRAQLRRLLRFSGLRALAALDAFALN 407

  Fly   413 HTKVNIGGVSSTY----RDSRSAPFHWMQDLKPEEIKQIQDVCTEAMDLWGYRR 462
            .|:....|....:    ||:|.|...|.:.|..|:::|::..|..||.|..|.|
Human   408 MTRGAAYGADRPFHLSARDAREAVHAWRERLSREQVRQVEAACAPAMRLLAYPR 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31637	NP_001285677.1	Sulfotransfer_1	187..459	CDD:304426	94/356 (26%)
CHST7	NP_063939.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	66..92		4/25 (16%)
CHST7	NP_063939.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..486		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144863
Domainoid	1	1.000	84	1.000	Domainoid score	I8227
eggNOG	1	0.900	-	-		E1_299AF
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	91	1.000	Inparanoid score	I5104
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1246608at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8642
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10704
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5525
SonicParanoid	1	1.000	-	-		X233
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.890