DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9547 and Gcdh

DIOPT Version :9

Sequence 1:	NP_609040.1	Gene:	CG9547 / 33911	FlyBaseID:	FBgn0031824	Length:	419	Species:	Drosophila melanogaster
Sequence 2:	NP_001038209.2	Gene:	Gcdh / 270076	MGIID:	104541	Length:	447	Species:	Mus musculus

Alignment Length:	410	Identity:	270/410 - (65%)
Similarity:	331/410 - (80%)	Gaps:	11/410 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SKLRPCARRLASTSSKAAAPKFNWQDPLNLESQLTEEEVAIRDAFRGYCQAELQPRVKMANRLET 72
            :::||         :|::.|.|:|:|||.||.|||.:|..|||.||.|||..|..|:.:|||.|.
Mouse    45 TQIRP---------AKSSRPVFDWKDPLILEEQLTADEKLIRDTFRNYCQERLMSRILLANRNEV 100

  Fly    73 FDKKIMEEIGSLGVLGCTIKGYGCAGVSSVAYGLLTREVERVDSAYRSAVSVQSSLAMGAIYDFG 137
            |.:.|:.|:|.|||||.|||||||||||||||||||||:|||||.|||.:||||||.|..||.:|
Mouse   101 FHRDIVYEMGELGVLGPTIKGYGCAGVSSVAYGLLTRELERVDSGYRSMMSVQSSLVMHPIYTYG 165

  Fly   138 SEEQKQRYLPSMAEGKLIGAFGLTEPNHGSDPAGMETRAKYDSKSKTYILNGSKTWITSAPIADV 202
            ||||:|:|||.:|:|:|:|.||||||||||||.||||||:::..:::|.|:|:|||||::|:||:
Mouse   166 SEEQRQKYLPGLAKGELLGCFGLTEPNHGSDPGGMETRARHNPSNQSYTLSGTKTWITNSPVADL 230

  Fly   203 IVVWAKCEDGKVRGFLVDRKISGKGLETPKIEGKFSLRASPTGMILMDEVRVPEEQLLPNVAGFS 267
            .:|||:|||..:|||::::.:  :||..|:||||||||||.||||:||.|.||||.:||||:..:
Mouse   231 FIVWARCEDNCIRGFILEKGM--RGLSAPRIEGKFSLRASATGMIIMDSVEVPEENVLPNVSSLA 293

  Fly   268 GPFSCLNNARYGIAWGALGAAETCVEIARQYTLDRKQFGRPLAANQLIQKKLADAITEIALGLQA 332
            |||.|||.|||||.||.|||||.|:..||||.|||.|||.|||.|||:||||||.:|||.|||.|
Mouse   294 GPFGCLNTARYGITWGVLGAAEFCLHTARQYALDRIQFGVPLARNQLVQKKLADMLTEITLGLHA 358

  Fly   333 CLHVGRLKDQKLHTPDMISLLKRNNTGKSLDIARQMRDMLGANGISDEYHVIRHVINLESVNTYE 397
            ||.:||||||...||:|:|:|||||.||:||||||.||:||.||||||||||||.:|||:|||||
Mouse   359 CLQLGRLKDQDKATPEMVSMLKRNNCGKALDIARQARDILGGNGISDEYHVIRHAMNLEAVNTYE 423

  Fly   398 GTHDIHALILGRAITGLAAF 417
            ||||||||||||||||:.||
Mouse   424 GTHDIHALILGRAITGIQAF 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9547	NP_609040.1	GCD	29..417	CDD:173840	264/387 (68%)
CG9547	NP_609040.1	CaiA	41..417	CDD:224871	256/375 (68%)
Gcdh	NP_001038209.2	GCD	57..443	CDD:173840	264/387 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833706
Domainoid	1	1.000	224	1.000	Domainoid score	I2558
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H130
Inparanoid	1	1.050	561	1.000	Inparanoid score	I1086
Isobase	1	0.950	-	0	Normalized mean entropy	S2100
OMA	1	1.010	-	-		QHG61728
OrthoDB	1	1.010	-	-		D589058at2759
OrthoFinder	1	1.000	-	-		FOG0005817
OrthoInspector	1	1.000	-	-		oto92262
orthoMCL	1	0.900	-	-		OOG6_101810
Panther	1	1.100	-	-	LDO	PTHR42807
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2538
SonicParanoid	1	1.000	-	-		X4208
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750