DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31638 and CCDC102B

DIOPT Version :9

Sequence 1:	NP_723186.2	Gene:	CG31638 / 33910	FlyBaseID:	FBgn0051638	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	XP_016881462.1	Gene:	CCDC102B / 79839	HGNCID:	26295	Length:	527	Species:	Homo sapiens

Alignment Length:	483	Identity:	186/483 - (38%)
Similarity:	269/483 - (55%)	Gaps:	59/483 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 YGETEWEARESQRQRELHEARARAAQMEKTMKWWSDCTANWREKWSKVRNERNKAREESKQLSLK 102
            |...:|:..|..|.|||.|.:||||||||||:|||||||||||||||||.|||.||||.:||.:|
Human    62 YNTNKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIK 126

  Fly   103 LDGVMKEAHSLKR------EKNDLELQITQLKK-----EMEKVHTLMMKHAGQFHRA-------- 148
            |:..|||..:||:      :|..||.::||..|     |....||...:.:.|.|.:
Human   127 LEMAMKELSTLKKKQSLPPQKEALEAKVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKR 191

  Fly   149 --DTSEDAEANGRDANCSPDISSDGLKNINSEDGLV---TKLPNDVK-DLDIEEFAMKGAMPKHL 207
              .|.||..                    |.|.|:|   .||..::| :||..:....|......
Human   192 QFSTKEDTN--------------------NKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGE 236

  Fly   208 TELDEAAAAEEKRLIQQLSKDDFDEDYLLQKISMLQLRLDEAQKTLQAERDEKLELHKSIEKLTL 272
            |:......|....|..:::           :||.||:.|||.||.|..||:.:..|.|.||:|..
Human   237 TKTGLRLKAINLPLENEVT-----------EISALQVHLDEFQKILWKEREMRTALEKEIERLES 290

  Fly   273 EIQDVRGRQEEMRSAKQEAVRELLTLQEQHRAEMRIVNNSLQEEIAARENLERRLTELRTELEHL 337
            .:...:.:.||::.:|.:.|:|...|..||..||:.::.:::||..::.:.:|.:.|||.|||.|
Human   291 ALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERL 355

  Fly   338 QAENASEWGKRERLESEKLAMERDNKKLRAELRDYQERSDRKCRPMQAN--DVELRALQQELSER 400
            ||||.|||.|||.||.||..:||:|::|:.::::.:|..|:|.| :.||  ..:.:..|.:|.|:
Human   356 QAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNR-LSANSQSPDFKMSQIDLQEK 419

  Fly   401 NKEISEVKMSHAKLKKLLAETNTELGHAVRRAEQYEAEVKRLRQRVEELKRELAGAEDELDSAVN 465
            |:|:..::.::.||.:.......||.||..|.:|.|||||:||.||||||:.|...|||||.::|
Human   420 NQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLN 484

  Fly   466 QVRRLQRSNDELVGQTEGLQVQIQHLQN 493
            |:|:||||.||...:.|.|:.:::||||
Human   485 QIRKLQRSLDEEKERNENLETELRHLQN 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31638	NP_723186.2	DUF4201	284..457	CDD:290581	69/174 (40%)
		Ax_dynein_light	<300..369	CDD:287215	32/68 (47%)
		RILP-like	<312..448	CDD:304877	56/137 (41%)
CCDC102B	XP_016881462.1	KASH_CCD	345..511	CDD:291334	75/166 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28K4K
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1304833at2759
OrthoFinder	1	1.000	-	-		FOG0005832
OrthoInspector	1	1.000	-	-		otm40788
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.920