Protein Alignment CG31638 and MYH11

DIOPT Version :10

• Sequence 1: NP_723186.2
• Gene: CG31638 / 33910
• FlyBaseID: FBgn0051638
• Length: 704
• Species: Drosophila melanogaster
• Sequence 2: NP_001035203.1
• Gene: MYH11 / 4629
• HGNCID: 7569
• Length: 1979
• Species: Homo sapiens
• Alignment Length: 813
• Identity: 171/813 - (21%)
• Similarity: 311/813 - (38%)
• Gaps: 213/813 - (26%)

  Fly    34 MSARYGETEWEARESQRQR--------------ELHEARARAAQMEKTM---------------- 68
            |.||..|.|...::.|.:|              |..||..:..|:||..
Human   934 MEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD 998

  Fly    69 --------------KWWSDCTANWREKWSKVRN--------------------ERNKAREESKQL 99
                          :..||.|.|..|:..|.:|                    :..|:|:|.::|
Human   999 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKL 1063

  Fly   100 SLKLDGVMKEAHSLKREKNDLELQITQLKKEMEKVHTLMMKHAGQFHRADTSEDAEANGRDANCS 164
            ..||:|   :|.....:..||:.||.:||.::.|                  ::.|.....|...
Human  1064 KRKLEG---DASDFHEQIADLQAQIAELKMQLAK------------------KEEELQAALARLD 1107

  Fly   165 PDIS--SDGLKNINSEDGLVTKLPNDV--------------KDLDIEEFAMKGAMPKHLTE---- 209
            .:|:  ::.||.|...:|.::.|..|:              :||..|..|:|       ||
Human  1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK-------TELEDT 1165

  Fly   210 LDEAAAAEEKRLIQQLSKDDFDEDYLLQKISMLQLRLDEAQKTLQAERDEKLELH-KSIEKLTLE 273
            ||..|..:|.|..::            |::::|:..|||..::.:|:..|..:.| :::|:||.:
Human  1166 LDSTATQQELRAKRE------------QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218

  Fly   274 IQDVRGRQEEMRSAKQEAVRELLTLQEQH---RAEMRIVNNSLQEEIAARENLERRLTEL----- 330
            :       |:.:.||....:...||::::   ..|:|::..:.||....::.||.::.||
Human  1219 L-------EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1276

  Fly   331 -----RTEL----EHLQAENASEWGKRERLESEKLAMERDNKKLRAELRDYQERSDRKCRPMQAN 386
                 |.||    ..||.|..|..|.....|.:.:.:.:|...|.::|:|.||....:.|.....
Human  1277 DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1341

  Fly   387 DVELRALQQELSERNKEISEVKMSHAKLKKLLAETNTELGHAVRRAEQYEAEV-------KRLRQ 444
            ..:||.|::|.:....::.|...:...|::.::..|.:|..:.::.:.:.:.|       ||.::
Human  1342 STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1406

  Fly   445 RVEELKR---ELAGAEDELDSAVNQVRRLQRSNDELVGQTEGLQVQIQHLQNRRAPSPQL----- 501
            .:|.|.:   |.|.|.|:|:...|   |||:..|:||...:..:..:.:|:.::....||
Human  1407 EIENLTQQYEEKAAAYDKLEKTKN---RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1468

  Fly   502 ---------RGMGGVQLRNK--------IAVELPNDCLPNINDLRQIFDDSQAGLRSSHNGSDAA 549
                     |.....:.|.|        .|:|...:....:....::.......|.||.:.....
Human  1469 NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1533

  Fly   550 MHHAASVKRSSHTE----RTLLQQQQSSAAASAAAAAAAAAAFFDAKPTHLEENIFESKSRNLEF 610
            :|.....||:..|:    :|.|::.:....|:.           ||| ..||.|:...|.   :|
Human  1534 VHELEKSKRALETQMEEMKTQLEELEDELQATE-----------DAK-LRLEVNMQALKG---QF 1583

  Fly   611 ERAKQKFDNPHGQHHHHHQRQ------RSGNGRYGSAGSSASRANLALPLKGTTNGGSSSVSSKD 669
            ||..|..|..:.:.....|||      ...:.|...|.::|::..|...||.......|::..::
Human  1584 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1648

  Fly   670 ELNRQLYEKEQSAGAGYARNSINLDGLKVSDDE 702
            |..:|| .|.|:....:.|   .|:..:.|.||
Human  1649 EAIKQL-RKLQAQMKDFQR---ELEDARASRDE 1677

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31638	NP_723186.2	Smc	<233..>496	CDD:440809	66/290 (23%)
MYH11	NP_001035203.1	Myosin_N	31..76	CDD:460670
		MYSc_class_II	99..778	CDD:276951
		Actin-binding. /evidence=ECO:0000250	668..690
		Actin-binding. /evidence=ECO:0000250	769..783
		Myosin_tail_1	855..1935	CDD:460256	171/813 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	865..889
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1751..1807
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1873..1979
		C-terminal	1942..1979