DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment epsilonCOP and Cope

DIOPT Version :9

Sequence 1:	NP_609037.1	Gene:	epsilonCOP / 33908	FlyBaseID:	FBgn0027496	Length:	306	Species:	Drosophila melanogaster
Sequence 2:	XP_006252938.1	Gene:	Cope / 290659	RGDID:	1306785	Length:	308	Species:	Rattus norvegicus

Alignment Length:	289	Identity:	113/289 - (39%)
Similarity:	168/289 - (58%)	Gaps:	10/289 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LFDARNEYYIGNFMGSIN------FVLPEQGTAGPELLSYMYLSYLAIDSGRIVASDIKEGNSTP 72
            |||.:|.:|||::...||      ...||:..   |...::|.:|||.....:|..:||..::..
  Rat    19 LFDVKNAFYIGSYQQCINEAQRVKLSSPEREV---ERDVFLYRAYLAQRKYGVVLDEIKPSSAPE 80

  Fly    73 LQALRLVHEAFEQPSRTEELLEKLTDKVAGEEDETN-IWHLATAIVYCHDGQFENALKILHGSTN 136
            |||:|:..|.....:|.:.::.:|..:::...|.|| .:.|..|.:|.||...:.||:.||....
  Rat    81 LQAVRMFAEYLASENRRDSIVLELDREMSRSVDVTNTTFLLMAASIYFHDQNPDAALRTLHQGDG 145

  Fly   137 LESMALSVQCLLRLQRVDLAKQLVAKMQEISDDATLTQLAQAWVALAQGTEQMQDAFHIYQEFCE 201
            ||..|:::|.||:|.|:|||::.:.:|||..:||||||||.|||.||.|.|::|:|::|:||..:
  Rat   146 LECTAMTIQILLKLDRLDLARKELKRMQEQDEDATLTQLATAWVNLAMGGEKLQEAYYIFQELAD 210

  Fly   202 KFKPTPALLNGQAVVHLGLERYEEADSVLRESLLKKHNDYDTLINLMVHAHLTGKPTEAITRNLE 266
            |..||..||||||..|....|:|.|:.||:|:|.|.....:|||||:|.:...|||.|...|.|.
  Rat   211 KCSPTLLLLNGQAACHSAQGRWETAEGVLQEALDKDSGHPETLINLIVLSQHLGKPPEVTNRYLS 275

  Fly   267 QLRQFYPKSDFVTDLDKKSAEFDRLCLQY 295
            ||:..:....|:.:...|..:||||.|||
  Rat   276 QLKDAHRTHPFIKEYQAKENDFDRLALQY 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
epsilonCOP	NP_609037.1	Coatomer_E	12..296	CDD:252768	113/289 (39%)
		TPR repeat	175..201	CDD:276809	14/25 (56%)
		TPR repeat	206..236	CDD:276809	15/29 (52%)
Cope	XP_006252938.1	Coatomer_E	17..305	CDD:398419	113/289 (39%)
		TPR repeat	185..210	CDD:276809	13/24 (54%)
		TPR repeat	215..245	CDD:276809	15/29 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353641
Domainoid	1	1.000	191	1.000	Domainoid score	I3148
eggNOG	1	0.900	-	-		E1_KOG3081
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5254
Inparanoid	1	1.050	191	1.000	Inparanoid score	I3790
OMA	1	1.010	-	-		QHG54590
OrthoDB	1	1.010	-	-		D1161199at2759
OrthoFinder	1	1.000	-	-		FOG0004888
OrthoInspector	1	1.000	-	-		oto98172
orthoMCL	1	0.900	-	-		OOG6_102500
Panther	1	1.100	-	-	LDO	PTHR10805
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4002
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770