Protein Alignment epsilonCOP and COPE

DIOPT Version :10

• Sequence 1: NP_609037.1
• Gene: epsilonCOP / 33908
• FlyBaseID: FBgn0027496
• Length: 306
• Species: Drosophila melanogaster
• Sequence 2: NP_001317398.1
• Gene: COPE / 11316
• HGNCID: 2234
• Length: 331
• Species: Homo sapiens
• Alignment Length: 312
• Identity: 112/312 - (35%)
• Similarity: 172/312 - (55%)
• Gaps: 33/312 - (10%)

  Fly    14 LFDARNEYYIGNFMGSIN------FVLPEQGTAGPELLSYMYLSYLAIDSGRIVASDIKEGNSTP 72
            |||.:|.:|||::...||      ...||:..   |...::|.:|||.....:|..:||..::..
Human    19 LFDVKNAFYIGSYQQCINEAQRVKLSSPERDV---ERDVFLYRAYLAQRKFGVVLDEIKPSSAPE 80

  Fly    73 LQALRLVHEAFEQPSRTEELLEKLTDKVAGEEDETN-IWHLATAIVYCHDGQFENALKILHGSTN 136
            |||:|:..:.....||.:.::.:|..:::...|.|| .:.|..|.:|.||...:.||:.||...:
Human    81 LQAVRMFADYLAHESRRDSIVAELDREMSRSVDVTNTTFLLMAASIYLHDQNPDAALRALHQGDS 145

  Fly   137 LE-----------------------SMALSVQCLLRLQRVDLAKQLVAKMQEISDDATLTQLAQA 178
            ||                       ..|::||.||:|.|:|||::.:.:||::.:||||||||.|
Human   146 LEWVSSPGRALHLEAQPMEAASPDGRTAMTVQILLKLDRLDLARKELKRMQDLDEDATLTQLATA 210

  Fly   179 WVALAQGTEQMQDAFHIYQEFCEKFKPTPALLNGQAVVHLGLERYEEADSVLRESLLKKHNDYDT 243
            ||:||.|.|::|||::|:||..:|..||..||||||..|:...|:|.|:.:|:|:|.|.....:|
Human   211 WVSLATGGEKLQDAYYIFQEMADKCSPTLLLLNGQAACHMAQGRWEAAEGLLQEALDKDSGYPET 275

  Fly   244 LINLMVHAHLTGKPTEAITRNLEQLRQFYPKSDFVTDLDKKSAEFDRLCLQY 295
            |:||:|.:...|||.|...|.|.||:..:....|:.:...|..:||||.|||
Human   276 LVNLIVLSQHLGKPPEVTNRYLSQLKDAHRSHPFIKEYQAKENDFDRLVLQY 327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
epsilonCOP	NP_609037.1	Coatomer_E	12..296	CDD:398419	112/312 (36%)
		TPR repeat	175..201	CDD:276809	15/25 (60%)
		TPR repeat	206..236	CDD:276809	14/29 (48%)
COPE	NP_001317398.1	Coatomer_E	17..328	CDD:398419	112/312 (36%)
		TPR repeat	238..268	CDD:276809	14/29 (48%)