DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KFase and Afmid

DIOPT Version :9

Sequence 1:	NP_001285676.1	Gene:	KFase / 33907	FlyBaseID:	FBgn0031821	Length:	300	Species:	Drosophila melanogaster
Sequence 2:	NP_001350087.1	Gene:	Afmid / 71562	MGIID:	2448704	Length:	377	Species:	Mus musculus

Alignment Length:	241	Identity:	74/241 - (30%)
Similarity:	120/241 - (49%)	Gaps:	29/241 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 YGEGR-QLVDVFYSEKTTNQAPLFVFVHGGYWQEMDMSMSCSIVGPLVRRGYRVAVMDYNLCPQV 123
            ||:|. :.:|:::.::.:...|||:|:||||||......|..:|.||..:|..|.::.|::.|:.
Mouse    72 YGDGEGEKLDIYFPDEDSKAFPLFLFLHGGYWQSGSKDDSAFMVNPLTAQGIVVVIVAYDIAPKG 136

  Fly   124 TLEQLMTQFTHFLNWIFDYTEMTKVSSLTFAGHSAGAHLLAQILM--------RPNVITAQRSKM 180
            ||:|::.|.|..:  :|..........:...||||||||.|.:|:        .||
Mouse   137 TLDQMVDQVTRSV--VFLQRRYPSNEGIYLCGHSAGAHLAAMVLLARWTKHGVTPN--------- 190

  Fly   181 VWALIFLCGVYDLRELSNLESVNPKNILGLNERNIESVSPMLWEYTDVT----VWNSTKIYVVAA 241
            :...:.:.|:|||..|......:|   |.:...:.:..||.  .:.||.    |..:..:.|:..
Mouse   191 LQGFLLVSGIYDLEPLIATSQNDP---LRMTLEDAQRNSPQ--RHLDVVPAQPVAPACPVLVLVG 250

  Fly   242 EHDSTTFIEQSRHYADVLRKKGYKASFTLFKGYDHFDIIEETAIDD 287
            :|||..|..||:.:.:.|.:.|:||||...:|.|||||||....:|
Mouse   251 QHDSPEFHRQSKEFYETLLRVGWKASFQQLRGVDHFDIIENLTRED 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KFase	NP_001285676.1	Aes	<67..297	CDD:223730	71/233 (30%)
KFase	NP_001285676.1	Abhydrolase	82..276	CDD:304388	60/205 (29%)
Afmid	NP_001350087.1	Aes	5..285	CDD:223730	66/228 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835936
Domainoid	1	1.000	90	1.000	Domainoid score	I7785
eggNOG	1	0.900	-	-		E1_COG0657
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41731
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4723
Isobase	1	0.950	-	0	Normalized mean entropy	S6194
OMA	1	1.010	-	-		QHG63382
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002751
OrthoInspector	1	1.000	-	-		oto93989
orthoMCL	1	0.900	-	-		OOG6_107374
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3743
SonicParanoid	1	1.000	-	-		X4210
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.640