Protein Alignment KFase and Nceh1

DIOPT Version :10

• Sequence 1: NP_609036.1
• Gene: KFase / 33907
• FlyBaseID: FBgn0287695
• Length: 300
• Species: Drosophila melanogaster
• Sequence 2: NP_848887.1
• Gene: Nceh1 / 320024
• MGIID: 2443191
• Length: 408
• Species: Mus musculus
• Alignment Length: 267
• Identity: 57/267 - (21%)
• Similarity: 103/267 - (38%)
• Gaps: 78/267 - (29%)

  Fly    37 VRVTKQHGRELTEKQGITVDHLRYGEGRQLVDVFYSEKTTNQAPL---FVFVHGGYWQEMDMSMS 98
            |:||.      |:..|:.|   |..||        |.|.  :.||   .:::|||.|......:|
Mouse    80 VKVTD------TDFDGVEV---RVFEG--------SPKP--EEPLRRSVIYIHGGGWALASAKIS 125

  Fly    99 -----CSIVGPLVRRGYRVAVMDYNLCPQVTLEQLMTQFTHFLNWIFDYTEMTKV---------- 148
                 |:.:...:..  .:..::|.|.|||          :|...|.|....||.
Mouse   126 YYDQLCTTMAEELNA--VIVSIEYRLVPQV----------YFPEQIHDVIRATKYFLQPEVLDKY 178

  Fly   149 ----SSLTFAGHSAGAHLLAQILMRPNVITAQRSKM-VWALIF-LCGVYDLRELSNLESVN---- 203
                ..:..:|.|||.:|.|.:..:...:.:.::|: :.||:: :....|....|..:|:|
Mouse   179 KVDPGRVGISGDSAGGNLAAALGQQFTYVASLKNKLKLQALVYPVLQALDFNTPSYQQSMNTPIL 243

  Fly   204 PKNI-----LGLNERNIESVSPMLWEYTDVTVWNSTKIYV-----VAAEHDSTTFIEQS--RHYA 256
            |:::     |...:.|.:.|..|:       |.|.|.:.|     :.|..|.|:.:..|  ::|.
Mouse   244 PRHVMVRYWLDYFKGNYDFVEAMI-------VNNHTSLDVERAAALRARLDWTSLLPSSIKKNYK 301

  Fly   257 DVLRKKG 263
            .:::..|
Mouse   302 PIMQTTG 308

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KFase	NP_609036.1	Aes	68..295	CDD:440422	48/236 (20%)
Nceh1	NP_848887.1	Abhydrolase_3	109..381	CDD:400284	44/219 (20%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	113..115		1/1 (100%)