Protein Alignment KFase and Aadacl3

DIOPT Version :10

• Sequence 1: NP_609036.1
• Gene: KFase / 33907
• FlyBaseID: FBgn0287695
• Length: 300
• Species: Drosophila melanogaster
• Sequence 2: NP_001078972.1
• Gene: Aadacl3 / 230883
• MGIID: 2685281
• Length: 408
• Species: Mus musculus
• Alignment Length: 258
• Identity: 60/258 - (23%)
• Similarity: 97/258 - (37%)
• Gaps: 71/258 - (27%)

  Fly    45 RELTEKQGITVDHLRYGEGRQLVDV-FYSEKTTNQAPL--FVFVHGGYWQE----------MDMS 96
            :.|.....:.|..|.:|    .:.| .|..|..:..|.  .:|.|||....          :.:|
Mouse    80 KPLKRDPDVVVKDLHFG----TIPVKLYKPKKPSSIPRLGIIFFHGGGTIIGSLRTHNSICLRLS 140

  Fly    97 MSCSIVGPLVRRGYRVAVMDYNLCPQVTLEQLMTQFTHFLNWIFDY-TEMTKVSSLTFAGHSAG- 159
            ..|..|  :|..|||.:.| |..  .|..:..:...||||..:..| .:..:|.:   .|.|.|
Mouse   141 KECDSV--VVSVGYRKSPM-YKY--PVMKDDCVVATTHFLESLDVYGVDPARVVT---CGDSVGG 197

  Fly   160 --AHLLAQILM-RPNV--ITAQRSKMVWALIFLCGVYDLRELSNLESVNPKNILGLNERNIESVS 219
              |.:.:|:|: ||::  |.||           ..:|.|.:|.:..|.:.:     ..|||
Mouse   198 TAATVTSQMLVHRPDLPRIKAQ-----------ILIYPLLQLIDFGSPSYQ-----QNRNI---- 242

  Fly   220 PML-WE--------YTDVTV-WNSTKIYVVAAEHDSTTFIEQSRHY------ADVLRKKGYKA 266
            |:| |:        :.||.: |.|.   |....|......|:.|.:      .:..:.:|||:
Mouse   243 PLLSWDLAFYCFCCHLDVNISWKSV---VKNGMHLPPDVWEKYRKWLGAENIPERFKNRGYKS 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KFase	NP_609036.1	Aes	68..295	CDD:440422	56/235 (24%)
Aadacl3	NP_001078972.1	Abhydrolase_3	116..379	CDD:400284	52/218 (24%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	120..122		1/1 (100%)