Protein Alignment KFase and AADAC

DIOPT Version :10

• Sequence 1: NP_609036.1
• Gene: KFase / 33907
• FlyBaseID: FBgn0287695
• Length: 300
• Species: Drosophila melanogaster
• Sequence 2: NP_001077.2
• Gene: AADAC / 13
• HGNCID: 17
• Length: 399
• Species: Homo sapiens
• Alignment Length: 177
• Identity: 43/177 - (24%)
• Similarity: 65/177 - (36%)
• Gaps: 46/177 - (25%)

  Fly    29 NLAV------LEHFVRVTKQHGR--EL--TEKQGITVDHLRYGEGRQLVDVFYSEKTTN--QAPL 81
            |||.      |.||:...|..|.  |:  |..:.:||...::  ...||.|:..::.:.  :..|
Human    45 NLATFVELLGLHHFMDSFKVVGSFDEVPPTSDENVTVTETKF--NNILVRVYVPKRKSEALRRGL 107

  Fly    82 FVFVHGGYWQEMDMSMSCSIVGPLVRRGYR-------------VAVMDYNLCPQVTLEQLMTQFT 133
            | ::|||.|        |  ||.....||.             |...:|.|.|:...........
Human   108 F-YIHGGGW--------C--VGSAALSGYDLLSRWTADRLDAVVVSTNYRLAPKYHFPIQFEDVY 161

  Fly   134 HFLNWIFDYTEMTKV----SSLTFAGHSAGAHLLA----QILMRPNV 172
            :.|.|......:.|.    ..:..:|.|||.:|.|    |:|..|:|
Human   162 NALRWFLRKKVLAKYGVNPERIGISGDSAGGNLAAAVTQQLLDDPDV 208

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KFase	NP_609036.1	Aes	68..295	CDD:440422	29/128 (23%)
AADAC	NP_001077.2	Abhydrolase_3	107..374	CDD:400284	28/113 (25%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	111..113		1/1 (100%)