DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sec61alpha and SSH1

DIOPT Version :9

Sequence 1:	NP_001285674.1	Gene:	Sec61alpha / 33905	FlyBaseID:	FBgn0086357	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_009842.1	Gene:	SSH1 / 852586	SGDID:	S000000487	Length:	490	Species:	Saccharomyces cerevisiae

Alignment Length:	486	Identity:	150/486 - (30%)
Similarity:	249/486 - (51%)	Gaps:	21/486 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GIKFLEVIKPFCSILPEIAKPERKIQFREKVLWTAITLFIFLVCCQIPLFGIMSSDSA---DPFY 63
            |.:.::::||...||||:..|..|:.|.:|:::|.....|:|. .|.||.|:..:.:.   ||.|
Yeast     3 GFRLIDIVKPILPILPEVELPFEKLPFDDKIVYTIFAGLIYLF-AQFPLVGLPKATTPNVNDPIY 66

  Fly    64 WIRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVG-DTPKDRALFNGAQKLFGMVITIGQ 127
            ::|.:......||:|.|:.|.::||||:|||||.|:|:|. ....||.||....|:|.:|..:..
Yeast    67 FLRGVFGCEPRTLLEFGLFPNISSGLILQLLAGLKVIKVNFKIQSDRELFQSLTKVFAIVQYVIL 131

  Fly   128 AIVYVMTGMYGDP-SEIGAGVCLLIIIQLFAAGLIVLLLDELLQKGYGLGSGISLFIATNICETI 191
            ..:::..|.:||. |.:..|   ||..||..||:...||.|::.||:|..||..:.....|...:
Yeast   132 TNIFIFAGYFGDDLSVVQIG---LINFQLVGAGIFTTLLAEVIDKGFGFSSGAMIINTVVIATNL 193

  Fly   192 VWKAFSPTTVTTGRG--TEFEGAVIALFH-LMATRNDKVRALREAFYRQNLPNLMNLLATVLVFA 253
            |...|..:.:..|..  ||.:||:|.|.. |.:.....:..:..||.|..||||...:..:.:..
Yeast   194 VADTFGVSQIKVGEDDQTEAQGALINLIQGLRSKHKTFIGGIISAFNRDYLPNLTTTIIVLAIAI 258

  Fly   254 VVIYFQGFRVDLPIKSARYRGQYSSYPIKLFYTSNIPIILQSALVSNL----YVISQMLAVKFQG 314
            :|.|.|..||:|||:|.|.||..:.|||||.||..:.::....::..:    :|:.|::|.....
Yeast   259 IVCYLQSVRVELPIRSTRARGTNNVYPIKLLYTGCLSVLFSYTILFYIHIFAFVLIQLVAKNEPT 323

  Fly   315 NFFINLLGVWADVGGGGPARSYPIGGLCYYLSPPESVGHILT-DPIHALLYIVFMLGSCAFFSKT 378
            :....::|.:.:........::|:.    .|:||.|....:| .|:..:.|..|:|.:..:|:..
Yeast   324 HIICKIMGHYENANNLLAVPTFPLS----LLAPPTSFFKGVTQQPLTFITYSAFILVTGIWFADK 384

  Fly   379 WIDVSGSSAKDVAKQLKEQHMVMRGHRENSMIHELNRYIPTAAAFGGLCIGALSVMADFLGAIGS 443
            |..:|||||:|||.:.|:|.:.:.|.||.::..|||:.||.||..|...:..::|:.:.||..|.
Yeast   385 WQAISGSSARDVALEFKDQGITLMGRREQNVAKELNKVIPIAAVTGASVLSLITVIGESLGLKGK 449

  Fly   444 GTGILLAVTIIYQYFEIFVKEQSEMGGMGTL 474
            ..||::.:...:...|:...|..:.||...|
Yeast   450 AAGIVVGIAGGFSLLEVITIEYQQSGGQSAL 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec61alpha	NP_001285674.1	PTZ00219	1..469	CDD:185519	147/479 (31%)
SSH1	NP_009842.1	PTZ00219	1..472	CDD:185519	147/476 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344096
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0201
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S126
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10906
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.750