Protein Alignment Sec61alpha and SEC61A1

DIOPT Version :9

• Sequence 1: NP_001285674.1
• Gene: Sec61alpha / 33905
• FlyBaseID: FBgn0086357
• Length: 476
• Species: Drosophila melanogaster
• Sequence 2: NP_037468.1
• Gene: SEC61A1 / 29927
• HGNCID: 18276
• Length: 476
• Species: Homo sapiens
• Alignment Length: 476
• Identity: 425/476 - (89%)
• Similarity: 452/476 - (94%)
• Gaps: 0/476 - (0%)

  Fly     1 MGIKFLEVIKPFCSILPEIAKPERKIQFREKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWI 65
            |.|||||||||||.|||||.||||||||:|||||||||||||||||||||||||||||||||||:
Human     1 MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWM 65

  Fly    66 RVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMVITIGQAIV 130
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||:||
Human    66 RVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQSIV 130

  Fly   131 YVMTGMYGDPSEIGAGVCLLIIIQLFAAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKA 195
            ||||||||||||:|||:||||.||||.||||||||||||||||||||||||||||||||||||||
Human   131 YVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKA 195

  Fly   196 FSPTTVTTGRGTEFEGAVIALFHLMATRNDKVRALREAFYRQNLPNLMNLLATVLVFAVVIYFQG 260
            ||||||.||||.|||||:||||||:|||.|||||||||||||||||||||:||:.||||||||||
Human   196 FSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQG 260

  Fly   261 FRVDLPIKSARYRGQYSSYPIKLFYTSNIPIILQSALVSNLYVISQMLAVKFQGNFFINLLGVWA 325
            ||||||||||||||||::||||||||||||||||||||||||||||||:.:|.||..::|||.|:
Human   261 FRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVISQMLSARFSGNLLVSLLGTWS 325

  Fly   326 DVGGGGPARSYPIGGLCYYLSPPESVGHILTDPIHALLYIVFMLGSCAFFSKTWIDVSGSSAKDV 390
            |...|||||:||:||||||||||||.|.:|.||:||::|||||||||||||||||:|||||||||
Human   326 DTSSGGPARAYPVGGLCYYLSPPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSGSSAKDV 390

  Fly   391 AKQLKEQHMVMRGHRENSMIHELNRYIPTAAAFGGLCIGALSVMADFLGAIGSGTGILLAVTIIY 455
            |||||||.||||||||.||:|||||||||||||||||||||||:|||||||||||||||||||||
Human   391 AKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIY 455

  Fly   456 QYFEIFVKEQSEMGGMGTLLF 476
            ||||||||||||:|.||.|||
Human   456 QYFEIFVKEQSEVGSMGALLF 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec61alpha	NP_001285674.1	PTZ00219	1..469	CDD:185519	419/467 (90%)
SEC61A1	NP_037468.1	PTZ00219	1..471	CDD:185519	420/469 (90%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147942
Domainoid	1	1.000	705	1.000	Domainoid score	I124
eggNOG	1	0.900	-	-		E1_COG0201
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	882	1.000	Inparanoid score	I401
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62204
OrthoDB	1	1.010	-	-		D266122at33208
OrthoFinder	1	1.000	-	-		FOG0001962
OrthoInspector	1	1.000	-	-		otm41528
orthoMCL	1	0.900	-	-		OOG6_100672
Panther	1	1.100	-	-	O	PTHR10906
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1289
SonicParanoid	1	1.000	-	-		X1283
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800