DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9536 and TMEM115

DIOPT Version :9

Sequence 1:	NP_001188706.1	Gene:	CG9536 / 33904	FlyBaseID:	FBgn0031818	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_008955.1	Gene:	TMEM115 / 11070	HGNCID:	30055	Length:	351	Species:	Homo sapiens

Alignment Length:	307	Identity:	122/307 - (39%)
Similarity:	183/307 - (59%)	Gaps:	10/307 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LARNWPYIWQQLNALLHNTSPVITLICVVTTFGYLLSFS-ETAILLLSVTPGYILPNGKFWIWTA 68
            :.|..|...|.|.|:|.:.|.|:..:|....|.|||||: :|.  .|:|||||:.| ..|||||.
Human     1 MQRALPGARQHLGAILASASVVVKALCAAVLFLYLLSFAVDTG--CLAVTPGYLFP-PNFWIWTL 62

  Fly    69 FTFCFIELHWWEVAVDVVTVGLCGKMLEPLWGQLEMFKFFALSNFGVSLLTTVYYLFYYMVTKNP 133
            .|...:|.|.|:||:.:.||.:.|::||||||.||:..||::.|..|.||....||..||.:.|.
Human    63 ATHGLMEQHVWDVAISLTTVVVAGRLLEPLWGALELLIFFSVVNVSVGLLGAFAYLLTYMASFNL 127

  Fly   134 TILFEVHIHGLAGYVAGICVAVRQIMPDHLIFKTRYGRLTNRNVPLTVLIMAIILWAIGLLDGTY 198
            ..||.|.|||..|::.|:.||::|.|.|.::.:....|::  .:|:.:|.:.::|....||....
Human   128 VYLFTVRIHGALGFLGGVLVALKQTMGDCVVLRVPQVRVS--VMPMLLLALLLLLRLATLLQSPA 190

  Fly   199 PAMFASGSLVSWIYLRFYQHHPNGRGDSSESFTFVSFFPNVSQPFISVLVNPIYNCCLRAGVV-K 262
            .|.:..|.|.||:||||||.|..||||.::.|.|.:|||.:.||.:.:|.|.:::..::..:. |
Human   191 LASYGFGLLSSWVYLRFYQRHSRGRGDMADHFAFATFFPEILQPVVGLLANLVHSLLVKVKICQK 255

  Fly   263 TPTPLRTISTASLTSVSVQMPGVDPHDIERRRQIALKALSERLKATD 309
            |   ::.....:.:|:::.:||.||.|.|||||:|||||:||||..:
Human   256 T---VKRYDVGAPSSITISLPGTDPQDAERRRQLALKALNERLKRVE 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9536	NP_001188706.1	DUF1751	54..157	CDD:285722	47/102 (46%)
TMEM115	NP_008955.1	Mediates homooligomerization. /evidence=ECO:0000269\|PubMed:24806965	1..205		80/208 (38%)
		DUF1751	49..151	CDD:285722	47/102 (46%)
		Mediates localization to the Golgi. /evidence=ECO:0000269\|PubMed:24806965	206..229		12/22 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..351
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145923
Domainoid	1	1.000	102	1.000	Domainoid score	I6886
eggNOG	1	0.900	-	-		E1_KOG2890
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I3478
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55580
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003023
OrthoInspector	1	1.000	-	-		oto90492
orthoMCL	1	0.900	-	-		OOG6_103163
Panther	1	1.100	-	-	LDO	PTHR13377
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2368
SonicParanoid	1	1.000	-	-		X2370
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790