Protein Alignment mmy and UAP1L1

DIOPT Version :10

• Sequence 1: NP_609032.1
• Gene: mmy / 33903
• FlyBaseID: FBgn0259749
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: XP_047280022.1
• Gene: UAP1L1 / 91373
• HGNCID: 28082
• Length: 583
• Species: Homo sapiens
• Alignment Length: 578
• Identity: 251/578 - (43%)
• Similarity: 338/578 - (58%)
• Gaps: 100/578 - (17%)

  Fly    38 MTDYLSLHSRLAQVGQEHLLKFWPELTNDERIDLVRDIEELNLDEIKLYFDRAT-VSMNENGIKL 101
            |.....:.:||.:.||||||:||.||..:.|..|:.::..|..:.::.:..||. .....:|...
Human     1 MASEQDVRARLQRAGQEHLLRFWAELAPEPRAALLAELALLEPEALREHCRRAAEACARPHGPPP 65

  Fly   102 D--DRLQPLP--------------------EGK-----------------------------LIS 115
            |  .||:|||                    |||                             |.:
Human    66 DLAARLRPLPPERVGRASRSDPETRRRWEEEGKRGGRPWGPAGGRAHGAGGNRGRARGTVVLLAT 130

  Fly   116 IAR------------APLEKLDAYRDE---------------GLLQISNGHVAVLLMAGGQGTRL 153
            :.|            ||..:|.:.:.|               |..|||...|||||:||||||||
Human   131 LRRVSPHAFRPPSPGAPAPELVSPKAEGWAGPGRPFTAPVPPGFRQISLNKVAVLLLAGGQGTRL 195

  Fly   154 GFDHPKGMYDVGLQSRKTLFRIQAERILKLEELAQEANGKRGHITWYIMTSEHTVQPTYDYFVAN 218
            |..:|||||.|||.|||||:::|||||.::|:||.|.:|.|..:.||:||||.|:.||.::|..:
Human   196 GVTYPKGMYRVGLPSRKTLYQLQAERIRRVEQLAGERHGTRCTVPWYVMTSEFTLGPTAEFFREH 260

  Fly   219 NFFGLKAENVLLFEQGSLPCFEYDGRIILDEKHRVARAPDGNGGIYRAMKRQGILDDMQKRGVLY 283
            |||.|...||::|||..||...:||::||:.|.:||.|||||||:|.|::...||:||::|||.:
Human   261 NFFHLDPANVVMFEQRLLPAVTFDGKVILERKDKVAMAPDGNGGLYCALEDHKILEDMERRGVEF 325

  Fly   284 LHAHSVDNILIKVADPVFIGYCVQEKADCAAKVVEKAAPNEAVGVVAIVDGKYQVVEYSEISAKT 348
            :|.:.|||||:::|||||||:||.:.|||.|||||||.|.|.||||..|||..|||||||||.:|
Human   326 VHVYCVDNILVRLADPVFIGFCVLQGADCGAKVVEKAYPEEPVGVVCQVDGVPQVVEYSEISPET 390

  Fly   349 AEMRNSDGRLTFSAGNICNHFFSSNFLQKIGSTYEQELKLHVAKKKIPFVDNAGKRLTPDKPNGI 413
            |::|.|||.|.::|||||||||:..||:.:...:|..||.|||.||:|:||..|..:.|.|||||
Human   391 AQLRASDGSLLYNAGNICNHFFTRGFLKAVTREFEPLLKPHVAVKKVPYVDEEGNLVKPLKPNGI 455

  Fly   414 KIEKFVFDVFEFAQKFVAMEVPRDEEFSALKNSDAAGKDCPSTARSDLHRLHKKYIEGAGG---I 475
            |:||||||||.||:.|.|:||.|:||||.|||::.|.:|.|.|||..|...|.::...||.   .
Human   456 KMEKFVFDVFRFAKNFAALEVLREEEFSPLKNAEPADRDSPRTARQALLTQHYRWALRAGARFLD 520

  Fly   476 VHG----------------EVCEISPFVTYAGENLASHVEGKSFTSPVYLRD--SRDP 515
            .||                .:|||||.|:|:||.|..:::|:.|.||:.|.:  :|:|
Human   521 AHGAWLPELPSLPPNGDPPAICEISPLVSYSGEGLEVYLQGREFQSPLILDEDQAREP 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmy	NP_609032.1	UDPGlcNAc_PPase	125..447	CDD:133036	189/336 (56%)
UAP1L1	XP_047280022.1	UDPGlcNAc_PPase	173..489	CDD:133036	188/315 (60%)