Protein Alignment HemK1 and HEMK2

DIOPT Version :10

• Sequence 1: NP_609031.2
• Gene: HemK1 / 33902
• FlyBaseID: FBgn0031817
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_037372.4
• Gene: HEMK2 / 29104
• HGNCID: 16021
• Length: 214
• Species: Homo sapiens
• Alignment Length: 206
• Identity: 55/206 - (26%)
• Similarity: 81/206 - (39%)
• Gaps: 35/206 - (16%)

  Fly   102 PLQHIIGEWDFMDITLKTSPSVFIPRPETEEFMRLVIDDHKNAKHVDL------LEVGCGSGAMS 160
            |....:|...|.|:.          .|..:.|:.|   |...|...:|      ||||.|||.:|
Human     9 PFHGHVGRGAFSDVY----------EPAEDTFLLL---DALEAAAAELAGVEICLEVGSGSGVVS 60

  Fly   161 LSMLHSL--PQVVATAIERSKAATVLAAENAKMLGLLNRFEVHNHTMEEDKYLPEALKDKKYDLI 223
             :.|.|:  ||.:....:.:..|.....|.|:    .|:..:.....:..|.|...|.: |.||:
Human    61 -AFLASMIGPQALYMCTDINPEAAACTLETAR----CNKVHIQPVITDLVKGLLPRLTE-KVDLL 119

  Fly   224 ISNPPYVKTEEFQFLHPEVVVYENLNAL-DGGSDGLRVARLVFDLACRHLRPGGKLWL-ELGNDH 286
            :.|||||.|.      |:.|....:.|. .||.:|..|....|.|....|.|.|..:| .:..::
Human   120 VFNPPYVVTP------PQEVGSHGIEAAWAGGRNGREVMDRFFPLVPDLLSPRGLFYLVTIKENN 178

  Fly   287 PPMVKTIMNLK 297
            |..:..||..|
Human   179 PEEILKIMKTK 189

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HemK1	NP_609031.2	HemK	46..322	CDD:442135	55/206 (27%)
HEMK2	NP_037372.4	AdoMet_MTases	21..213	CDD:473071	52/194 (27%)