DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment frj and MBOAT7

DIOPT Version :9

Sequence 1:	NP_609029.1	Gene:	frj / 33900	FlyBaseID:	FBgn0031815	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_077274.3	Gene:	MBOAT7 / 79143	HGNCID:	15505	Length:	472	Species:	Homo sapiens

Alignment Length:	485	Identity:	159/485 - (32%)
Similarity:	246/485 - (50%)	Gaps:	30/485 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSIDDVIYVICLLGCIGAGSYVKKIADEGQRKLVSTGLGVLVVVIVSGLHSLHCFVSLALGTAAV 65
            ||.::..|::.||..|..|...|| |..|.::..:..:|:.:.:...|.|:||..|:: |||.|:
Human     1 MSPEEWTYLVVLLISIPIGFLFKK-AGPGLKRWGAAAVGLGLTLFTCGPHTLHSLVTI-LGTWAL 63

  Fly    66 LLVHPSKGHLVTFAVMFGYLVFFRIFDFYFGIP---GHTNMIQMILTLKVSGIAFEKTAAWKRLQ 127
            :...|...|.:..|..|.||:|||.... .|:|   ..||.:|::||||:..:|.|..      .
Human    64 IQAQPCSCHALALAWTFSYLLFFRALSL-LGLPTPTPFTNAVQLLLTLKLVSLASEVQ------D 121

  Fly   128 AHDEQKKNDQRDVHQESPIEITDYDVELQSLSAAEILHYSFNYIGVLTGPYYRYRTYRDYFEMPF 192
            .|..|:| :......:.|......||.    |..|.|.||:.|:|::|||::|||||.|:.|.||
Human   122 LHLAQRK-EMASGFSKGPTLGLLPDVP----SLMETLSYSYCYVGIMTGPFFRYRTYLDWLEQPF 181

  Fly   193 KTYAPTVEATLEKLKYAVFYCALYLATNYMWPLDYALSDEFFNDRSFVYRLLYVWPTFFTFRARI 257
            ....|::...|.:...|..:..|:|.:::::||: |:.::.|..|....||.|:.|.||.||.|.
Human   182 PGAVPSLRPLLRRAWPAPLFGLLFLLSSHLFPLE-AVREDAFYARPLPARLFYMIPVFFAFRMRF 245

  Fly   258 YTGLTLSECVCTMAGFGAYPDESDPNNGEGPRKRY--QHLKRDADKHTYNFTTIVNTRVLEVERC 320
            |.....:||.|..|||||||..:....|.||..:.  ......|....|::.||.|......:.|
Human   246 YVAWIAAECGCIAAGFGAYPVAAKARAGGGPTLQCPPPSSPEKAASLEYDYETIRNIDCYSTDFC 310

  Fly   321 WTFREGMKHWNVCVQYWLAVNVYKLFPSKKY--RTGATLLCSAYWHGFRPGHYFCIMGAPFYVSL 383
            ...|:||::||:.||:|||..:||..|::.|  |:..|:|.||||||..||:|...:..|..::.
Human   311 VRVRDGMRYWNMTVQWWLAQYIYKSAPARSYVLRSAWTMLLSAYWHGLHPGYYLSFLTIPLCLAA 375

  Fly   384 EDMWDKLVRKSATGTSRRVIDVIFWIFKWFAFSYLGEAFLLSSFGNIWRFYSSVYHIGYISWAAM 448
            |...:..:|...:...::..|.:.|..|..|:.|:...|:|.|..:..|:::|:|..  |.:.|:
Human   376 EGRLESALRGRLSPGGQKAWDWVHWFLKMRAYDYMCMGFVLLSLADTLRYWASIYFC--IHFLAL 438

  Fly   449 TALGFYLT------SQRKAAERRKKRAAEK 472
            .|||..|.      |:||||.:....|.||
Human   439 AALGLGLALGGGSPSRRKAASQPTSLAPEK 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frj	NP_609029.1	MBOAT	93..427	CDD:281107	111/340 (33%)
MBOAT7	NP_077274.3	MBOAT	2..431	CDD:294479	143/443 (32%)
MBOAT7	NP_077274.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	453..472		8/16 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145066
Domainoid	1	1.000	173	1.000	Domainoid score	I3722
eggNOG	1	0.900	-	-		E1_COG5202
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11510
Inparanoid	1	1.050	243	1.000	Inparanoid score	I3326
Isobase	1	0.950	-	0	Normalized mean entropy	S3521
OMA	1	1.010	-	-		QHG48036
OrthoDB	1	1.010	-	-		D475957at33208
OrthoFinder	1	1.000	-	-		FOG0006514
OrthoInspector	1	1.000	-	-		oto90807
orthoMCL	1	0.900	-	-		OOG6_107524
Panther	1	1.100	-	-	LDO	PTHR13906
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2628
SonicParanoid	1	1.000	-	-		X3655
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750