DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment frj and Mboat7

DIOPT Version :9

Sequence 1:	NP_609029.1	Gene:	frj / 33900	FlyBaseID:	FBgn0031815	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_084210.2	Gene:	Mboat7 / 77582	MGIID:	1924832	Length:	473	Species:	Mus musculus

Alignment Length:	486	Identity:	156/486 - (32%)
Similarity:	249/486 - (51%)	Gaps:	31/486 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSIDDVIYVICLLGCIGAGSYVKKIADEGQRKLVSTGLGVLVVVIVSGLHSLHCFVSLALGTAAV 65
            |:.::..|::.||..|..|...|| |..|.::..:..:|:.:.:...|.||||..::: |||.|:
Mouse     1 MTPEEWTYLMVLLISIPVGFLFKK-AGPGLKRWGAAAVGLGLTLFTCGPHSLHSLITI-LGTWAL 63

  Fly    66 LLVHPSKGHLVTFAVMFGYLVFFRIFDFYFGIP---GHTNMIQMILTLKVSGIAFEKTAAWKRLQ 127
            :...|...|.:..|..|.||:|||.... .|:|   ..||.:|::||||:..:|.|..      .
Mouse    64 IQAQPCSCHALALAWTFSYLLFFRALSL-LGLPTPTPFTNAVQLLLTLKLVSLASEVQ------D 121

  Fly   128 AHDEQKKNDQRDVHQESPIEITDYDVELQSLSAAEILHYSFNYIGVLTGPYYRYRTYRDYFEMPF 192
            .|..|:|......|:|..:.:..   |:.||  .|.|.||:.|:|::|||::|||||.|:.|.||
Mouse   122 LHLAQRKEIASGFHKEPTLGLLP---EVPSL--METLSYSYCYVGIMTGPFFRYRTYLDWLEQPF 181

  Fly   193 KTYAPTVEATLEKLKYAVFYCALYLATNYMWPLDYALSDEFFNDRSFVYRLLYVWPTFFTFRARI 257
            ....|::...|.:...|..:..|:|.:::::||: |:.::.|..|....||.|:.|.||.||.|.
Mouse   182 PEAVPSLRPLLRRAWPAPLFGLLFLLSSHLFPLE-AVREDAFYARPLPTRLFYMIPVFFAFRMRF 245

  Fly   258 YTGLTLSECVCTMAGFGAYPDESDPNNGEGPRKRY--QHLKRDADKHTYNFTTIVNTRVLEVERC 320
            |.....:||.|..|||||||..:....|.||..:.  ......|....|::.||.|......:.|
Mouse   246 YVAWIAAECGCIAAGFGAYPVAAKARAGGGPTLQCPPPSSPEIAASLEYDYETIRNIDCYGTDFC 310

  Fly   321 WTFREGMKHWNVCVQYWLAVNVYKLFPSKKY--RTGATLLCSAYWHGFRPGHYFCIMGAPFYVSL 383
            ...|:||::||:.||:|||..:||..|.:.|  |:..|:|.||||||..||:|...|..|..::.
Mouse   311 VRVRDGMRYWNMTVQWWLAQYIYKSAPFRSYVLRSAWTMLLSAYWHGLHPGYYLSFMTIPLCLAA 375

  Fly   384 EDMWDKLVRKSATGTSRRVIDVIFWIFKWFAFSYLGEAFLLSSFGNIWRFYSSVYHIGYISWAAM 448
            |...:..:|:..:...::..|.:.|..|..|:.|:...|:|.|..:..|:::|:|.  ::.:.|:
Mouse   376 EGYLESALRRHLSPGGQKAWDWVHWFLKMRAYDYMCMGFVLLSMADTLRYWASIYF--WVHFLAL 438

  Fly   449 TALGFYLT------SQRKA-AERRKKRAAEK 472
            ..||..|.      |:||. ::....:|.||
Mouse   439 ACLGLGLVLGGGSPSKRKTPSQATSSQAKEK 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frj	NP_609029.1	MBOAT	93..427	CDD:281107	113/340 (33%)
Mboat7	NP_084210.2	MBOAT	8..431	CDD:382173	144/437 (33%)
Mboat7	NP_084210.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..473		6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835175
Domainoid	1	1.000	192	1.000	Domainoid score	I3218
eggNOG	1	0.900	-	-		E1_COG5202
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11510
Inparanoid	1	1.050	244	1.000	Inparanoid score	I3283
Isobase	1	0.950	-	0	Normalized mean entropy	S3521
OMA	1	1.010	-	-		QHG48036
OrthoDB	1	1.010	-	-		D881262at2759
OrthoFinder	1	1.000	-	-		FOG0006514
OrthoInspector	1	1.000	-	-		oto94390
orthoMCL	1	0.900	-	-		OOG6_107524
Panther	1	1.100	-	-	LDO	PTHR13906
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2628
SonicParanoid	1	1.000	-	-		X3655
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750