DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment frj and Mboat2

DIOPT Version :9

Sequence 1:	NP_609029.1	Gene:	frj / 33900	FlyBaseID:	FBgn0031815	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_080313.2	Gene:	Mboat2 / 67216	MGIID:	1914466	Length:	519	Species:	Mus musculus

Alignment Length:	501	Identity:	108/501 - (21%)
Similarity:	187/501 - (37%)	Gaps:	88/501 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSIDDVIYVICLLGCIGAGSYVKKIADEGQ-----RKLVSTGLGVLVVVIVSGLHSLHCFVSLAL 60
            :.||.|.:|:|.|..:.|..:.:......:     |.:|:|.||:.:.....|.::||..|...:
Mouse    21 LPIDQVNFVVCQLFALLAAVWFRTYLHSSKTSSFIRHVVATLLGLYLAFFCFGWYALHFLVQSGI 85

  Fly    61 GTAAVLLVHPSKGHLVTFAVMFGYL---VFFRIFDFYFG-IPGHTNMIQMILTLKVSGIAFEKTA 121
            ....:::..........|....|||   ...|::.|.:| .....:...||:|.|::.:|:|
Mouse    86 SYCIMIIAGVESMQQCCFVFALGYLSVCQITRVYIFDYGQYSADFSGPMMIITQKITSLAYE--- 147

  Fly   122 AWKRLQAHDEQKKNDQRDVHQESPIEITDYDVELQSLSAAEILHYSFNYIGVLTGPYYRYRTYRD 186
                  .||...:.|:.....:..:.:.      :..|..|.:.|:.|::|:|.||...|:.|..
Mouse   148 ------IHDGMFRKDEELTPSQRGLAVR------RMPSLLEYVSYTCNFMGILAGPLCSYKDYIA 200

  Fly   187 YFEMPFKTYAPTVE----------------ATLEKLKYAVFYCALYLATNYMWPLDYALSDEFFN 235
            :.|......|...|                |..|||.........:|..:.|.|::|.:.:.|..
Mouse   201 FIEGRASHVAQPSENGKDEQHGKADPSPNAAVTEKLLVCGLSLLFHLTISNMLPVEYNIDEHFQA 265

  Fly   236 DRSFVYRLLYVWPTFFTFRARIYTGLTLSECVCTMAGFGAYPDESDPNNGEGPRKRYQHLKRDAD 300
            ..|:..:..|::.:....|.:.|...||::.:...||||.                     |..|
Mouse   266 TASWPTKATYLYVSLLAARPKYYFAWTLADAINNAAGFGF---------------------RGYD 309

  Fly   301 KH-TYNFTTIVNTRVLEVERCWTFREGMKHWNVCVQYWLAVNVYK---LFPSKKYRTGATLLCSA 361
            |: ...:..|.|.|:.::|...:|:..:.:||:....||....|:   ..|     |..|...||
Mouse   310 KNGVARWDLISNLRIQQIEMSTSFKMFLDNWNIQTALWLKRVCYERATFSP-----TIQTFFLSA 369

  Fly   362 YWHGFRPGHYFCIMGAPFYVSLEDMWDKLVRKSATGTSRRVI----------DVIFWIFKWFAFS 416
            .|||..||:|...        |..:...|..::.....|...          |:|.|:......|
Mouse   370 IWHGVYPGYYLTF--------LTGVLMTLAARAVRNNFRHYFLEPPQLKLFYDLITWVATQITIS 426

  Fly   417 YLGEAFLLSSFGNIWRFYSSVYHIGYISWAAMTALGFYLTSQRKAA 462
            |....|:|.|....:.||||.|:..::....:..|.....|||:.:
Mouse   427 YTVVPFVLLSIKPSFTFYSSWYYCLHVCSILVLLLLPVKKSQRRTS 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frj	NP_609029.1	MBOAT	93..427	CDD:281107	77/364 (21%)
Mboat2	NP_080313.2	MBOAT	13..476	CDD:294479	108/501 (22%)
Mboat2	NP_080313.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..519
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5202
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D881262at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820