DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment retm and SEC14L5

DIOPT Version :9

Sequence 1:	NP_001260132.1	Gene:	retm / 33899	FlyBaseID:	FBgn0031814	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_055507.1	Gene:	SEC14L5 / 9717	HGNCID:	29032	Length:	696	Species:	Homo sapiens

Alignment Length:	712	Identity:	312/712 - (43%)
Similarity:	433/712 - (60%)	Gaps:	81/712 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVQKFQSPVRVYKYPFELVMKAYERRFPTCPQMPIVLDCEVIKDESLEDGAKRNTSRRCKLAVDA 65
            |||::|||||||||||||||.|||:|||||||:|:.|..||:::....|||.....|.|:|.|||
Human     1 MVQRYQSPVRVYKYPFELVMAAYEKRFPTCPQIPVFLGSEVLRESRSPDGAVHVVERSCRLRVDA 65

  Fly    66 PYIFKKLIGVDHVYFLQHNFLDLANRTLSIEAVNESFSSRIEIFERCRYYAHPDNSEWTCFDQSA 130
            |.:.:|:.||:||.|:|.|.|:...|||.|||.||:|::|:.:.|.|.|..||:|.:||||:|||
Human    66 PRLLRKIAGVEHVVFVQTNILNWKERTLLIEAHNETFANRVVVNEHCSYTVHPENEDWTCFEQSA 130

  Fly   131 TLDIKNFFGFEHSMEKMGMKQYTQTTLKGKEIIEFFIGQLREEGITHVERWTSPSDATKSPTLDQ 195
            :|||::|||||:::||:.|||||....:|||:||.::.:|..:|.:|:.||| |:...:....:|
Human   131 SLDIRSFFGFENALEKIAMKQYTANVKRGKEVIEHYLNELISQGTSHIPRWT-PAPVREEDARNQ 194

  Fly   196 ASDQQHSIL----------------------LDGDFIARSLGQLSPMQESKLLELRKMLDGVDDL 238
            |..:..|.|                      ||.|:|.|.||.|:|||||.|::||..|.....
Human   195 AGPRDPSSLEAHGPRSTLGPALEAVSMDGDKLDADYIERCLGHLTPMQESCLIQLRHWLQETHK- 258

  Fly   239 ERVPSYQTILRFLAARDWHVSQAYAMLCDSLRWRREHRIDALLAEYSKPAVVVEHFPGGWHHLDK 303
            .::|..:.|||||.|.|:|:.:|..||..||.||::|::|.||..:..||::.|.:.||||:.|.
Human   259 GKIPKDEHILRFLRAHDFHLDKAREMLRQSLSWRKQHQVDLLLQTWQPPALLEEFYAGGWHYQDI 323

  Fly   304 DGRPVYILRLGHMDVKGLLKSLGMDGLLRLALHICEEGIQKINESAERLEKPVLNWSLLVDLEGL 368
            ||||:||||||.||.|||:|::|.:.|||..|.:.|||.::...|..:|.:|:.:|:.|:|||||
Human   324 DGRPLYILRLGQMDTKGLMKAVGEEALLRHVLSVNEEGQKRCEGSTRQLGRPISSWTCLLDLEGL 388

  Fly   369 SMRHLWRPGIKALLNIIETVERNYPETMGRVLVVRAPRVFPIAWTIVSAFIDEHTRSKFLFYGPD 433
            :||||||||:||||.:||.||.|||||:||:|:||||||||:.||::|.||:|:||.|||.|...
Human   389 NMRHLWRPGVKALLRMIEVVEDNYPETLGRLLIVRAPRVFPVLWTLISPFINENTRRKFLIYSGS 453

  Fly   434 CAHMKDGLAQYLDEEIVPDFLGGPCKTMIHEGGLVPKTLYKMNSLEDHDDEVTAELPTTAAAQAL 498
            ......||..|||.|::||||||.....:.|||||||:||.....::|.|::.....|
Human   454 NYQGPGGLVDYLDREVIPDFLGGESVCNVPEGGLVPKSLYMTEEEQEHTDQLWQWSET------- 511

  Fly   499 VPGKRLSANQQHDHRNLYKSVDLKAGFAHELLIRNEDPKSVLTWDFDVMRNDLHFTLYRVTQELP 563
                             |.|..:..|..||:.:...:.:||:|||||::|.|:.|:||. |::.|
Human   512 -----------------YHSASVLRGAPHEVAVEILEGESVITWDFDILRGDVVFSLYH-TKQAP 558

  Fly   564 -----EKNDSAVSYFDLQDFVEGVNYFREEPTLICRHKESVQGSHVMHHNDSYLMHW--FSP--- 618
                 |....|......:.:|.|.:|.|.|..|:||..||:|||||......||:.|  .||
Human   559 RLGAREPGTRASGQLIDKGWVLGRDYSRVEAPLVCREGESIQGSHVTRWPGVYLLQWQMHSPPSS 623

  Fly   619 -----------------SGAQLNVFY--EVLSSANYKGSMTSLQ---SAFSSNSSAASSVQS 658
                             .|.:..:.|  |||:|.:::|||:||:   |.||..|:|.||..|
Human   624 VACSLPGVDDVLTALHSPGPKCKLLYYCEVLASEDFRGSMSSLESCTSGFSQLSAATSSSSS 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retm	NP_001260132.1	PRELI	17..173	CDD:282550	81/155 (52%)
		CRAL_TRIO_N	222..268	CDD:215024	18/45 (40%)
		CRAL_TRIO	293..456	CDD:279044	93/162 (57%)
SEC14L5	NP_055507.1	PRELI	17..173	CDD:309720	81/155 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..214		8/36 (22%)
		CRAL_TRIO_N	243..288	CDD:215024	18/45 (40%)
		SEC14	306..479	CDD:214706	98/172 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151934
Domainoid	1	1.000	218	1.000	Domainoid score	I2659
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H96163
Inparanoid	1	1.050	598	1.000	Inparanoid score	I962
Isobase	1	0.950	-	0	Normalized mean entropy	S2121
OMA	1	1.010	-	-		QHG49351
OrthoDB	1	1.010	-	-		D1133487at2759
OrthoFinder	1	1.000	-	-		FOG0000197
OrthoInspector	1	1.000	-	-		otm41917
orthoMCL	1	0.900	-	-		OOG6_100867
Panther	1	1.100	-	-	LDO	PTHR23324
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X399
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.720