DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment retm and SEC14

DIOPT Version :9

Sequence 1:	NP_001260132.1	Gene:	retm / 33899	FlyBaseID:	FBgn0031814	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_013796.1	Gene:	SEC14 / 855103	SGDID:	S000004684	Length:	304	Species:	Saccharomyces cerevisiae

Alignment Length:	264	Identity:	76/264 - (28%)
Similarity:	133/264 - (50%)	Gaps:	10/264 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 DFIARSLGQLSPMQESKLLELRKMLDGVDDLERVPSYQTILRFLAARDWHVSQAYAMLCDSLRWR 272
            |.:..:.|.|...||..|.||||:|:....:||:.. .|:||||.||.:.|..|..|..:..:||
Yeast    20 DALPGTPGNLDSAQEKALAELRKLLEDAGFIERLDD-STLLRFLRARKFDVQLAKEMFENCEKWR 83

  Fly   273 REHRIDALLAE--YSKPAVVVEHFPGGWHHLDKDGRPVYILRLGHMDVKGLLKSLGMDGLLRLAL 335
            :::..|.:|.:  |.:..::.:.:|..:|..||||||||...||.:::..:.|....:.:|:..:
Yeast    84 KDYGTDTILQDFHYDEKPLIAKFYPQYYHKTDKDGRPVYFEELGAVNLHEMNKVTSEERMLKNLV 148

  Fly   336 HICEEGIQKINESAERLEKPVLNWS-LLVDLEGLSMRHLWRPGIKALLNIIETVERN-YPETMGR 398
            ...|..:|....:..|....::..| .::||:|:|:...:  .:.:.:.....:.:| |||.||:
Yeast   149 WEYESVVQYRLPACSRAAGHLVETSCTIMDLKGISISSAY--SVMSYVREASYISQNYYPERMGK 211

  Fly   399 VLVVRAPRVFPIAWTIVSAFIDEHTRSKFLFYGPDCAHMKDGLAQYLDEEIVPDFLGGPCKTMIH 463
            ..::.||..|..|:.:...|:|..|.||....|  .::.|:.|.| :..|.:|...||..:....
Yeast   212 FYIINAPFGFSTAFRLFKPFLDPVTVSKIFILG--SSYQKELLKQ-IPAENLPVKFGGKSEVDES 273

  Fly   464 EGGL 467
            :|||
Yeast   274 KGGL 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retm	NP_001260132.1	PRELI	17..173	CDD:282550
		CRAL_TRIO_N	222..268	CDD:215024	19/45 (42%)
		CRAL_TRIO	293..456	CDD:279044	43/164 (26%)
SEC14	NP_013796.1	CRAL_TRIO_N	34..79	CDD:215024	19/45 (42%)
SEC14	NP_013796.1	SEC14	99..269	CDD:214706	45/174 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I2522
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2121
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000197
OrthoInspector	1	1.000	-	-		mtm9225
orthoMCL	1	0.900	-	-		OOG6_100867
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1304
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.690