DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment retm and PATL1

DIOPT Version :9

Sequence 1:	NP_001260132.1	Gene:	retm / 33899	FlyBaseID:	FBgn0031814	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_177360.1	Gene:	PATL1 / 843546	AraportID:	AT1G72150	Length:	573	Species:	Arabidopsis thaliana

Alignment Length:	583	Identity:	124/583 - (21%)
Similarity:	208/583 - (35%)	Gaps:	157/583 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ELVMKAYERRFPTCPQMPIVLDC-------EVIKDESLEDGAKRNTSRRCKLAVDAPYIFKKLIG 74
            |||.:|..:|..|.|..|:..:.       |..|:|...:..|..|:...|:..:.|
plant   102 ELVREALNKREFTAPVTPVKEEKTEEKKTEEETKEEEKTEEKKEETTTEVKVEEEKP-------- 158

  Fly    75 VDHVYFLQHNFLDLANRTLSIEAVNESFSSRIEIFERCRYYAHPDNSEWTCFDQSATLDIKNFFG 139
                               ::.|..|..||                       ::|.::.|:
plant   159 -------------------AVPAAEEEKSS-----------------------EAAPVETKS--- 178

  Fly   140 FEHSMEKMGMKQYTQTTLK-------GKEIIEFFIGQLREEGITHVERWTSPSDATKSPTLDQAS 197
                 |:...::...||.|       |.:.:|..     ||.|..|    ||.::..:|.:.:..
plant   179 -----EEKPEEKAEVTTEKASSAEEDGTKTVEAI-----EESIVSV----SPPESAVAPVVVETV 229

  Fly   198 DQQHSILLDGDFIARSLGQLSPMQESKLLELRKMLDGVDDLERVPSYQTILRFLAARDWHVSQAY 262
                           ::.:..|::..::     .:.||..|:...|...:.:||.|||:.|.:|.
plant   230 ---------------AVAEAEPVEPEEV-----SIWGVPLLQDERSDVILTKFLRARDFKVKEAL 274

  Fly   263 AMLCDSLRWRREHRIDAL------LAEYSKPAVVVEHFPGGWHHLDKDGRPVYILRLGHMDVKGL 321
            .||.::::||:|::||.|      ::|:.|....        |.:||:|..|.....|....|.|
plant   275 TMLKNTVQWRKENKIDELVESGEEVSEFEKMVFA--------HGVDKEGHVVIYSSYGEFQNKEL 331

  Fly   322 LKSL-GMDGLLRLALHICEEGIQKINESAERLEKPVLNWSLLVDLEGLSMRHLWRPGIKALLNII 385
            .... .::..|...:.:.|:.::.|:.|....:...:..|...:..||..|.||    :.:...:
plant   332 FSDKEKLNKFLSWRIQLQEKCVRAIDFSNPEAKSSFVFVSDFRNAPGLGKRALW----QFIRRAV 392

  Fly   386 ETVERNYPETMGRVLVVRAPRVF-PIAWTIVSAFIDEHTRSKFLFYGPDCAHMKDGLAQYLDEEI 449
            :..|.||||...:.|.:..|..: |...|..|......||||.:..||  :...|.:.:|:..|.
plant   393 KQFEDNYPEFAAKELFINVPWWYIPYYKTFGSIITSPRTRSKMVLAGP--SKSADTIFKYIAPEQ 455

  Fly   450 VPDFLGGPCK------TMIHEGGLVPKTLYKMNSLEDHDDEVTAELPTTAAA----QALVPGKRL 504
            ||...||..|      ..|.|..:.|...|            |.|||.:.|.    :..|.|..:
plant   456 VPVKYGGLSKDTPLTEETITEAIVKPAANY------------TIELPASEACTLSWELRVLGADV 508

  Fly   505 SANQQHDHRN-----LYKSVDLKAGFAHELLIRN-----EDPKSVLTWDFDVMRNDLHFTLYR 557
            |...|.:...     :..|...|.|...|.:|.:     |..|.|:|.|....:...  .|||
plant   509 SYGAQFEPTTEGSYAVIVSKTRKIGSTDEPVITDSFKVGEPGKIVITIDNQTSKKKK--VLYR 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retm	NP_001260132.1	PRELI	17..173	CDD:282550	27/169 (16%)
		CRAL_TRIO_N	222..268	CDD:215024	13/45 (29%)
		CRAL_TRIO	293..456	CDD:279044	39/164 (24%)
PATL1	NP_177360.1	CRAL_TRIO_N	<247..280	CDD:215024	12/32 (38%)
PATL1	NP_177360.1	SEC14	297..463	CDD:238099	42/179 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	71	1.000	Inparanoid score	I2453
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.860