DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment retm and SFH3

DIOPT Version :9

Sequence 1:	NP_001260132.1	Gene:	retm / 33899	FlyBaseID:	FBgn0031814	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_001031389.1	Gene:	SFH3 / 816693	AraportID:	AT2G21540	Length:	548	Species:	Arabidopsis thaliana

Alignment Length:	528	Identity:	123/528 - (23%)
Similarity:	220/528 - (41%)	Gaps:	94/528 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 SILLDGDFIARSLGQLSPMQESKLLELRKMLDGVDDLERVPS----YQTILRFLAARDWHVSQAY 262
            |:.:..|.....|..:...:::.:|:           |.:||    :..:||||.||.:.:.:|.
plant    58 SVSIVDDIDLEELQAVDAFRQALILD-----------ELLPSKHDDHHMMLRFLRARKFDLEKAK 111

  Fly   263 AMLCDSLRWRREHRIDALLAEYSKPAV--VVEHFPGGWHHLDKDGRPVYILRLGHMDVKGLLKSL 325
            .|..|.:.||:|..:|.::.::....:  |::::|.|:|.:|||||||||.|||.:|...|::..
plant   112 QMWTDMIHWRKEFGVDTIMEDFDFKEIDEVLKYYPQGYHGVDKDGRPVYIERLGQVDATKLMQVT 176

  Fly   326 GMDGLLRLALHICEEGIQ-KINESAERLEKPVLNWSLLVDLEGLSMRHLWRPGIKALLNIIETVE 389
            .:|..::..:...|:... |:...:...:|.:...:.::|::|:.::..    .||..::::.::
plant   177 TIDRYVKYHVREFEKTFNIKLPACSIAAKKHIDQSTTILDVQGVGLKSF----SKAARDLLQRIQ 237

  Fly   390 R----NYPETMGRVLVVRAPRVFPIAWTIVSAFIDEHTRSKFLFYGPDCAHMKDGLAQYLDEEIV 450
            :    |||||:.|:.::.|...|.:.|:.|.:|:|..|.:|....|   ...:..|.:.:|...:
plant   238 KIDSDNYPETLNRMFIINAGSGFRLLWSTVKSFLDPKTTAKIHVLG---NKYQSKLLEIIDSNEL 299

  Fly   451 PDFLGGPCKTMIHEGGLVPKTLYKMNSLEDHDDEVTAELPTTAAAQALVPGKRLSANQQHDHRNL 515
            |:||||.| |...:||.:.......|     |.::   .......:...|.|.||        |:
plant   300 PEFLGGNC-TCADKGGCMRSDKGPWN-----DPDI---FKMVQNGEGKCPRKTLS--------NI 347

  Fly   516 YK---SVDLKAGFAHELLIRN----EDPKSVLTWDFDVMRNDLHFTLYRVTQELPEKNDSAVSYF 573
            .:   |||.......:...:|    |:.|.:...|..|..:.....|::.....||...|||
plant   348 EEKTISVDENTTMKSDSFAKNKFDAENTKFIPMIDKTVNASTWPTNLHKSNYPEPEDLYSAV--- 409

  Fly   574 DLQDFVEGVNYFREEPTLICRHKESVQGSHVMHHNDSYLMHWFSPSGAQLNVFYEVLSSANYKGS 638
                          :|:. .|..|......||    |.:|...:......|:..::..:|.|.|.
plant   410 --------------KPSQ-RRGGEGYLFGGVM----SLVMGLMTVVRLTKNMPRKLTEAAIYGGE 455

  Fly   639 MTSLQSAFSSNSSAASSVQ--SRXYEKAGDGGTNGAEWRS----PALEEPIAADILTGTLM---E 694
            :...::...||....|.|:  :. .||.          ||    ||...|....|||..|.   |
plant   456 VDKAETTMVSNQEYMSMVKRMAELEEKC----------RSLDNQPAAFSPEKEQILTAALSRVDE 510

  Fly   695 KSLNLFET 702
            ..|.|.:|
plant   511 LELQLAQT 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retm	NP_001260132.1	PRELI	17..173	CDD:282550
		CRAL_TRIO_N	222..268	CDD:215024	12/49 (24%)
		CRAL_TRIO	293..456	CDD:279044	45/167 (27%)
SFH3	NP_001031389.1	CRAL_TRIO_N	71..117	CDD:215024	12/56 (21%)
SFH3	NP_001031389.1	SEC14	137..307	CDD:214706	48/176 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	89	1.000	Domainoid score	I2681
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1133487at2759
OrthoFinder	1	1.000	-	-		FOG0000197
OrthoInspector	1	1.000	-	-		otm2464
orthoMCL	1	0.900	-	-		OOG6_100867
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X399
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.720