DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment retm and Ttpal

DIOPT Version :9

Sequence 1:	NP_001260132.1	Gene:	retm / 33899	FlyBaseID:	FBgn0031814	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_083788.2	Gene:	Ttpal / 76080	MGIID:	1923330	Length:	343	Species:	Mus musculus

Alignment Length:	369	Identity:	81/369 - (21%)
Similarity:	132/369 - (35%)	Gaps:	73/369 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 TSPSDATKSPT---LDQASDQQHSILLDGDFIARSLGQLSPMQESKLLELRKMLDGVDDLERVPS 243
            ||||.|:.|..   |.......:...|..|.:.::..:|....|.:|.:::.:.|.|  .:..|.
Mouse    10 TSPSVASLSENELPLPPPDPPGYVCSLTEDLVTKAREELQEKPEWRLRDVQALRDMV--RKEYPY 72

  Fly   244 YQT------ILRFLAARDWHVSQAYAMLCDSLRWRREHRIDALLAEYSKPAVVVEHFPGGWHHLD 302
            ..|      :||||.||.:...:|..:|.:....||           |.|.|.....|.....:.
Mouse    73 LSTSLDDAFLLRFLRARKFDYDRALQLLVNYHGCRR-----------SWPEVFSNLRPSALKDVL 126

  Fly   303 KDGRPVYILRLGHMDVKGLLKSLGMDGLLRLALHI-C-------------EEGIQKINESAERL- 352
            ..|   ::..|.|.|.:|              .|: |             .|.|:.:..:.|:|
Mouse   127 NSG---FLTVLPHTDPRG--------------CHVLCIRPDRWIPSNYPITENIRAVYLTLEKLI 174

  Fly   353 ---EKPVLNWSLLVDLEGLSMRHLWRPGIKALLNIIETVERNYPETMGRVLVVRAPRVFPIAWTI 414
               |..|....:|.|.:|:|:......|......:|..::..:|..:..|.:|..||:|...:.|
Mouse   175 QSEETQVNGIVILADYKGVSLSKASHFGPFIAKKVIGILQDGFPIRIKAVHIVNEPRIFKGIFAI 239

  Fly   415 VSAFIDEHTRSKFLFYGPDCAHMKDGLAQYLDEEIVPDFLGGPCKTMIHEGGLVPKTLYK---MN 476
            :..|:.|...::|..:|.|.    :.|...|...|:|...||       ..|.:....:.   :.
Mouse   240 IKPFLKEKIANRFFLHGSDL----NSLHTNLPRNILPKEYGG-------TAGELDTASWNAVLLA 293

  Fly   477 SLEDHDDEVTAELPT--TAAAQALVPGKRLSANQQHDHRNLYKS 518
            |.||...|....:|.  ....|.|:|...:|..|..|.....||
Mouse   294 SEEDFVKEFCQPMPACDNLLGQPLLPEGLISDAQCDDSMRAMKS 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retm	NP_001260132.1	PRELI	17..173	CDD:282550
		CRAL_TRIO_N	222..268	CDD:215024	14/51 (27%)
		CRAL_TRIO	293..456	CDD:279044	36/180 (20%)
Ttpal	NP_083788.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		7/19 (37%)
		CRAL_TRIO_N	57..103	CDD:215024	12/47 (26%)
		SEC14	122..278	CDD:238099	37/183 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810