DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment retm and Sec14l1

DIOPT Version :9

Sequence 1:	NP_001260132.1	Gene:	retm / 33899	FlyBaseID:	FBgn0031814	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_083053.2	Gene:	Sec14l1 / 74136	MGIID:	1921386	Length:	719	Species:	Mus musculus

Alignment Length:	739	Identity:	327/739 - (44%)
Similarity:	446/739 - (60%)	Gaps:	111/739 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVQKFQSPVRVYKYPFELVMKAYERRFPTCPQMPIVLDCEVIKDESLEDGAKRNTSRRCKLAVDA 65
            ||||:||||||||:||||:|.||||||||||.:|:.:|.:.:.:...||||.....|||||.:||
Mouse     1 MVQKYQSPVRVYKHPFELIMAAYERRFPTCPLIPMFVDSDTVSEFKSEDGALHVIERRCKLDIDA 65

  Fly    66 PYIFKKLIGVDHVYFLQHNFLDLANRTLSIEAVNESFSSRIEIFERCRYYAHPDNSEWTCFDQSA 130
            |.:.||:.|||:|||:|.|.|:..:|||.|||.||:||:|:.|.|.|.|..||:|.:||||:|||
Mouse    66 PRLLKKIAGVDYVYFVQKNSLNSRDRTLHIEAHNETFSNRVIIHEHCCYTVHPENEDWTCFEQSA 130

  Fly   131 TLDIKNFFGFEHSMEKMGMKQYTQTTLKGKEIIEFFIGQLREEGITHVERWTSP----------- 184
            :||||:|||||.::||:.||.||....|||||||:::.||.|||||.|.|||.|
Mouse   131 SLDIKSFFGFESTVEKIAMKHYTSNIKKGKEIIEYYLRQLEEEGITFVPRWTPPPVGPSETCSSS 195

  Fly   185 ---------------------------SDATKS-PTLDQASDQQHSILLDGDFIARSLGQLSPMQ 221
                                       |..|.| |.:....|:     ||.|:|.|.||.|:|:|
Mouse   196 KNQVTSAAVLVPDAAAVMEGLSGENLSSPGTASEPVVGTPDDK-----LDADYIKRYLGDLTPLQ 255

  Fly   222 ESKLLELRKMLDGVDDLERVPSYQTILRFLAARDWHVSQAYAMLCDSLRWRREHRIDALLAEYSK 286
            ||.|:.||:.|..... .::|..:.|||||.|||:::.:|..::|.||.||::|::|.:|..::.
Mouse   256 ESCLIRLRQWLQETHK-GKIPKDEHILRFLRARDFNIDKAREIMCQSLTWRKQHQVDYILDTWTP 319

  Fly   287 PAVVVEHFPGGWHHLDKDGRPVYILRLGHMDVKGLLKSLGMDGLLRLALHICEEGIQKINESAER 351
            |.|:::::.|||||.||||||:|:||||.||.|||:::||.:.|||..|.|.|||:::..|:.:.
Mouse   320 PQVLLDYYAGGWHHHDKDGRPLYVLRLGQMDTKGLVRALGEEALLRYVLSINEEGLRRCEENTKV 384

  Fly   352 LEKPVLNWSLLVDLEGLSMRHLWRPGIKALLNIIETVERNYPETMGRVLVVRAPRVFPIAWTIVS 416
            ..:|:.:|:.|||||||:||||||||:||||.|||.||.|||||:||:|::|||||||:.||:||
Mouse   385 FGRPISSWTCLVDLEGLNMRHLWRPGVKALLRIIEVVEANYPETLGRLLILRAPRVFPVLWTLVS 449

  Fly   417 AFIDEHTRSKFLFYGPDCAHMKDGLAQYLDEEIVPDFLGGPCKTMIHEGGLVPKTLYK-MNSLED 480
            .|||::||.|||.|..:......||..|:|:||:||||.|.|...:.|||||||:||: ...||:
Mouse   450 PFIDDNTRRKFLIYAGNDYQGPGGLLDYIDKEIIPDFLSGECMCDVPEGGLVPKSLYRTAEELEN 514

  Fly   481 HDDEVTAELPTTAAAQALVPGKRLSANQQHDHRNLYKSVDLKAGFAHELLIRNEDPKSVLTWDFD 545
            .|.::..|                         .:|:|..:..|..||:||:..|..||:|||||
Mouse   515 EDLKLWTE-------------------------TIYQSASVFKGAPHEILIQIVDASSVITWDFD 554

  Fly   546 VMRNDLHFTLYRVTQE-LPEKNDSAVSY---------FDLQDFV--EGVNYFREEPTLICRHKES 598
            |.:.|:.|.:|...:. .|.|.||..::         ..|.|.|  .|.:|...|..|||:..||
Mouse   555 VCKGDIVFNIYHSKRSPQPPKKDSLGAHSITSPGGNNVQLIDKVWQLGRDYSMVESPLICKEGES 619

  Fly   599 VQGSHVMHHNDSYLMHW---FSPSGAQLNV---------------------FYEVLSSANYKGSM 639
            ||||||......|::.|   ..|:.|..|:                     :.||:.|.:::|||
Mouse   620 VQGSHVTRWPGFYILQWKFHTMPACAATNLPRVDDVLASLQVSSHKCKVMYYTEVIGSEDFRGSM 684

  Fly   640 TSLQSAFS--SNSSAA--SSVQSR 659
            |||:|:.|  |..|||  ||.||:
Mouse   685 TSLESSHSGFSQLSAATTSSSQSQ 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retm	NP_001260132.1	PRELI	17..173	CDD:282550	87/155 (56%)
		CRAL_TRIO_N	222..268	CDD:215024	17/45 (38%)
		CRAL_TRIO	293..456	CDD:279044	96/162 (59%)
Sec14l1	NP_083053.2	Required for interaction and inhibitory function toward DDX58. /evidence=ECO:0000250\|UniProtKB:Q92503	1..510		259/514 (50%)
		PRELI	17..173	CDD:282550	87/155 (56%)
		CRAL_TRIO_N	256..301	CDD:215024	17/45 (38%)
		CRAL_TRIO	326..490	CDD:279044	96/163 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	219	1.000	Domainoid score	I2629
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	589	1.000	Inparanoid score	I991
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49351
OrthoDB	1	1.010	-	-		D1133487at2759
OrthoFinder	1	1.000	-	-		FOG0000197
OrthoInspector	1	1.000	-	-		otm43965
orthoMCL	1	0.900	-	-		OOG6_100867
Panther	1	1.100	-	-	O	PTHR23324
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1304
SonicParanoid	1	1.000	-	-		X399
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870