DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment retm and TTPA

DIOPT Version :9

Sequence 1:	NP_001260132.1	Gene:	retm / 33899	FlyBaseID:	FBgn0031814	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_000361.1	Gene:	TTPA / 7274	HGNCID:	12404	Length:	278	Species:	Homo sapiens

Alignment Length:	247	Identity:	58/247 - (23%)
Similarity:	106/247 - (42%)	Gaps:	28/247 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 SPMQESKLLELRKML--DGVDDLERVPSYQT-ILRFLAARDWHVSQAYAMLCDSLRWRRE-HRID 278
            ||:.:..|..||:..  .|| .|..:|...: :||||.|||:.:..|:.:|.:..:||.| ..|.
Human    21 SPLLQPGLAALRRRAREAGV-PLAPLPLTDSFLLRFLRARDFDLDLAWRLLKNYYKWRAECPEIS 84

  Fly   279 ALLAEYSKPAVVVEHFPGGWHHL----DKDGRPVYILRLGHMDVKGLLKSLGMDGLLRLALHICE 339
            |.|    .|..::.....|:|.:    |..|..|.|.|:.|.|.|.....    .:.|::|...|
Human    85 ADL----HPRSIIGLLKAGYHGVLRSRDPTGSKVLIYRIAHWDPKVFTAY----DVFRVSLITSE 141

  Fly   340 EGIQKINESAERLEKPVLNWSLLVDLEGLSMRHLWRPGIKALLNIIETVERNYPETMGRVLVVRA 404
            ..:|::......::       .:.||||....|.::........|...:..::|..:..:.::..
Human   142 LIVQEVETQRNGIK-------AIFDLEGWQFSHAFQITPSVAKKIAAVLTDSFPLKVRGIHLINE 199

  Fly   405 PRVFPIAWTIVSAFIDEHTRSKFLFYGPDCAHMKDGLAQYLDEEIVPDFLGG 456
            |.:|...::::..|:.|..:.:...:|   .:.|..|.|:. .:|:|...||
Human   200 PVIFHAVFSMIKPFLTEKIKERIHMHG---NNYKQSLLQHF-PDILPLEYGG 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retm	NP_001260132.1	PRELI	17..173	CDD:282550
		CRAL_TRIO_N	222..268	CDD:215024	16/48 (33%)
		CRAL_TRIO	293..456	CDD:279044	31/166 (19%)
TTPA	NP_000361.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		CRAL_TRIO_N	<40..73	CDD:215024	12/33 (36%)
		CRAL_TRIO	99..248	CDD:395525	33/164 (20%)
		Phosphatidylinositol 3,4-bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:Q8BWP5	190..192		0/1 (0%)
		Phosphatidylinositol 4,5-bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:Q8BWP5	208..211		0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X399
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810