DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment retm and Sec14l2

DIOPT Version :9

Sequence 1:	NP_001260132.1	Gene:	retm / 33899	FlyBaseID:	FBgn0031814	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_653103.1	Gene:	Sec14l2 / 67815	MGIID:	1915065	Length:	403	Species:	Mus musculus

Alignment Length:	419	Identity:	112/419 - (26%)
Similarity:	198/419 - (47%)	Gaps:	75/419 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 LGQLSPMQESKLLELRKMLDGVDDLERVPSYQTILRFLAARDWHVSQAYAMLCDSLRWRREHRID 278
            :|.|||.||..|.:.|:.:..|......|....:||:|.||.:.:.::.|||...:.:|::..||
Mouse     5 VGDLSPKQEEALAKFRENVQDVLPTLPNPDDYFLLRWLRARSFDLQKSEAMLRKHVEFRKQKDID 69

  Fly   279 ALLAEYSKPAVVVEHFPGGWHHLDKDGRPVYILRLGHMDVKGLLKSLGMDGLLRLALHICEEGIQ 343
            .::: :..|.|:.::..||....|.||.||:...:|.:|.||||.|.....|||..:..||..:|
Mouse    70 KIIS-WQPPEVIQQYLSGGRCGYDLDGCPVWYDIIGPLDAKGLLFSASKQDLLRTKMRDCELLLQ 133

  Fly   344 KINESAERLEKPVLNWSLLVDLEGLSMRHLWRPGIKALLNIIETVERNYPETMGRVLVVRAPRVF 408
            :..:...:|.|.:...:::.|.|||.::|||:|.::|....:...|.|||||:.|:.||:||::|
Mouse   134 ECIQQTTKLGKKIETITMIYDCEGLGLKHLWKPAVEAYGEFLTMFEENYPETLKRLFVVKAPKLF 198

  Fly   409 PIAWTIVSAFIDEHTRSKFLFYGPDCAHMKDGLAQYLDEEIVPDFLGG---------PCKTMIHE 464
            |:|:.::..|:.|.||.|.:..|   |:.|:.|.:::..:.:|...||         .||:.|:.
Mouse   199 PVAYNLIKPFLSEDTRRKIMVLG---ANWKEVLLKHISPDQLPVEYGGTMTDPDGNPKCKSKINY 260

  Fly   465 GGLVPKTLYKMNSLEDHDDEVTAELPTTAAAQALVPGKRLSANQQHDHRNLYKSVDLKAGFAHEL 529
            ||.:||..|..:.::                            ||::|     :|.:..|.:|::
Mouse   261 GGDIPKQYYVRDQVK----------------------------QQYEH-----TVQVSRGSSHQV 292

  Fly   530 LIRNEDPKSVLTWDFDVMRNDLHFTLY------------RVTQELPEKNDSAVSYFDLQDFVEGV 582
            ......|..||.|.|....:|:.|.::            .:|:.||.:..::
Mouse   293 EYEILFPGCVLRWQFMSEGSDVGFGIFLKTKMGERQRAGEMTEVLPNQRYNS------------- 344

  Fly   583 NYFREEPTLICRHKESVQGSHVMHHNDSY 611
            :...|:.||.|    |..|.:|:..:::|
Mouse   345 HMVPEDGTLTC----SEPGIYVLRFDNTY 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retm	NP_001260132.1	PRELI	17..173	CDD:282550
		CRAL_TRIO_N	222..268	CDD:215024	13/45 (29%)
		CRAL_TRIO	293..456	CDD:279044	55/162 (34%)
Sec14l2	NP_653103.1	CRAL_TRIO_N	13..59	CDD:215024	13/45 (29%)
		SEC14	76..244	CDD:214706	58/170 (34%)
		GOLD_2	300..381	CDD:290608	17/87 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842066
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1133487at2759
OrthoFinder	1	1.000	-	-		FOG0000197
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1304
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.780