DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment retm and SEC14L1

DIOPT Version :9

Sequence 1:	NP_001260132.1	Gene:	retm / 33899	FlyBaseID:	FBgn0031814	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_001034662.3	Gene:	SEC14L1 / 6397	HGNCID:	10698	Length:	719	Species:	Homo sapiens

Alignment Length:	737	Identity:	326/737 - (44%)
Similarity:	446/737 - (60%)	Gaps:	99/737 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVQKFQSPVRVYKYPFELVMKAYERRFPTCPQMPIVLDCEVIKDESLEDGAKRNTSRRCKLAVDA 65
            ||||:|||||||||||||:|.||||||||||.:|:.:..:.:.:...||||.....|||||.|||
Human     1 MVQKYQSPVRVYKYPFELIMAAYERRFPTCPLIPMFVGSDTVNEFKSEDGAIHVIERRCKLDVDA 65

  Fly    66 PYIFKKLIGVDHVYFLQHNFLDLANRTLSIEAVNESFSSRIEIFERCRYYAHPDNSEWTCFDQSA 130
            |.:.||:.|||:|||:|.|.|:...|||.|||.||:||:|:.|.|.|.|..||:|.:||||:|||
Human    66 PRLLKKIAGVDYVYFVQKNSLNSRERTLHIEAYNETFSNRVIINEHCCYTVHPENEDWTCFEQSA 130

  Fly   131 TLDIKNFFGFEHSMEKMGMKQYTQTTLKGKEIIEFFIGQLREEGITHVERWTSPSDATKSPTLDQ 195
            :||||:|||||.::||:.|||||....|||||||:::.||.|||||.|.||:.||..|.|.|...
Human   131 SLDIKSFFGFESTVEKIAMKQYTSNIKKGKEIIEYYLRQLEEEGITFVPRWSPPSITTSSETSSS 195

  Fly   196 ASDQQHSIL----------------------------------LDGDFIARSLGQLSPMQESKLL 226
            :|.:|.:.:                                  ||.|:|.|.||.|:|:|||.|:
Human   196 SSKKQAASMAVVIPEAALKEGLSGDALSSPSAPEPVVGTPDDKLDADYIKRYLGDLTPLQESCLI 260

  Fly   227 ELRKMLDGVDDLERVPSYQTILRFLAARDWHVSQAYAMLCDSLRWRREHRIDALLAEYSKPAVVV 291
            .||:.|..... .::|..:.|||||.|||:::.:|..::|.||.||::|::|.:|..::.|.|:.
Human   261 RLRQWLQETHK-GKIPKDEHILRFLRARDFNIDKAREIMCQSLTWRKQHQVDYILETWTPPQVLQ 324

  Fly   292 EHFPGGWHHLDKDGRPVYILRLGHMDVKGLLKSLGMDGLLRLALHICEEGIQKINESAERLEKPV 356
            :::.|||||.||||||:|:||||.||.|||:::||.:.|||..|.|.|||:::..|:.:...:|:
Human   325 DYYAGGWHHHDKDGRPLYVLRLGQMDTKGLVRALGEEALLRYVLSINEEGLRRCEENTKVFGRPI 389

  Fly   357 LNWSLLVDLEGLSMRHLWRPGIKALLNIIETVERNYPETMGRVLVVRAPRVFPIAWTIVSAFIDE 421
            .:|:.|||||||:||||||||:||||.|||.||.|||||:||:|::|||||||:.||:||.|||:
Human   390 SSWTCLVDLEGLNMRHLWRPGVKALLRIIEVVEANYPETLGRLLILRAPRVFPVLWTLVSPFIDD 454

  Fly   422 HTRSKFLFYGPDCAHMKDGLAQYLDEEIVPDFLGGPCKTMIHEGGLVPKTLYK-MNSLEDHDDEV 485
            :||.|||.|..:......||..|:|:||:||||.|.|...:.|||||||:||: ...||:.|.::
Human   455 NTRRKFLIYAGNDYQGPGGLLDYIDKEIIPDFLSGECMCEVPEGGLVPKSLYRTAEELENEDLKL 519

  Fly   486 TAELPTTAAAQALVPGKRLSANQQHDHRNLYKSVDLKAGFAHELLIRNEDPKSVLTWDFDVMRND 550
            ..|                         .:|:|..:..|..||:||:..|..||:||||||.:.|
Human   520 WTE-------------------------TIYQSASVFKGAPHEILIQIVDASSVITWDFDVCKGD 559

  Fly   551 LHFTLYRVTQE-LPEKNDSAVSY---------FDLQDFV--EGVNYFREEPTLICRHKESVQGSH 603
            :.|.:|...:. .|.|.||..::         ..|.|.|  .|.:|...|..|||:..|||||||
Human   560 IVFNIYHSKRSPQPPKKDSLGAHSITSPGGNNVQLIDKVWQLGRDYSMVESPLICKEGESVQGSH 624

  Fly   604 VMHHNDSYLMHW----------------------FSPSGAQLNVFY--EVLSSANYKGSMTSLQS 644
            |......|::.|                      ...|..:..|.|  ||:.|.:::||||||:|
Human   625 VTRWPGFYILQWKFHSMPACAASSLPRVDDVLASLQVSSHKCKVMYYTEVIGSEDFRGSMTSLES 689

  Fly   645 AFS--SNSSAASSVQSRXYEKA 664
            :.|  |..|||::..|:.:..:
Human   690 SHSGFSQLSAATTSSSQSHSSS 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retm	NP_001260132.1	PRELI	17..173	CDD:282550	88/155 (57%)
		CRAL_TRIO_N	222..268	CDD:215024	17/45 (38%)
		CRAL_TRIO	293..456	CDD:279044	96/162 (59%)
SEC14L1	NP_001034662.3	PRELI	17..173	CDD:368069	88/155 (57%)
		CRAL_TRIO_N	256..301	CDD:215024	17/45 (38%)
		CRAL_TRIO	326..490	CDD:366224	96/163 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	218	1.000	Domainoid score	I2659
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	598	1.000	Inparanoid score	I962
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49351
OrthoDB	1	1.010	-	-		D1133487at2759
OrthoFinder	1	1.000	-	-		FOG0000197
OrthoInspector	1	1.000	-	-		otm41917
orthoMCL	1	0.900	-	-		OOG6_100867
Panther	1	1.100	-	-	O	PTHR23324
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1304
SonicParanoid	1	1.000	-	-		X399
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870