DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment retm and RLBP1

DIOPT Version :9

Sequence 1:	NP_001260132.1	Gene:	retm / 33899	FlyBaseID:	FBgn0031814	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	XP_016877949.1	Gene:	RLBP1 / 6017	HGNCID:	10024	Length:	326	Species:	Homo sapiens

Alignment Length:	320	Identity:	68/320 - (21%)
Similarity:	128/320 - (40%)	Gaps:	65/320 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 TLDQASDQQHSILLDGDFIARSLGQLSPMQESKLLELRKMLD---------GVDDLERVPSYQT- 246
            ||.:|.|:              |.:....:|..:.||::|:.         .|...|||....:
Human    53 TLQKAKDE--------------LNEREETREEAVRELQEMVQAQAASGEELAVAVAERVQEKDSG 103

  Fly   247 -ILRFLAARDWHVSQAYAMLCDSLRWRREH--RIDALLAEYSKPAVVVEHFPGGWHHLDKDGRPV 308
             .|||:.||.::|.:||.:|...:.:|.::  ..|:|..|..: ..:...:||.....||.||.|
Human   104 FFLRFIRARKFNVGRAYELLRGYVNFRLQYPELFDSLSPEAVR-CTIEAGYPGVLSSRDKYGRVV 167

  Fly   309 YILRLGHMDVKGLLKSLGMDGLLRLALHICEEGIQKINESAERLEKPVLNWSLLVDLEGLSMRHL 373
            .:..:.:..    .:.:..|.:|:....|.|:.::  ||     |..:..:.::.:.:|.:|:..
Human   168 MLFNIENWQ----SQEITFDEILQAYCFILEKLLE--NE-----ETQINGFCIIENFKGFTMQQA 221

  Fly   374 WRPGIKALLNIIETVERNYPETMGRVLVVRAPRVFPIAWTIVSAFIDEHTRSKFLFYGPDCAHMK 438
            .......|..:::.::.::|.....:..:..|..|...:.:|..|:......:...:|.|.:
Human   222 ASLRTSDLRKMVDMLQDSFPARFKAIHFIHQPWYFTTTYNVVKPFLKSKLLERVFVHGDDLS--- 283

  Fly   439 DGLAQYLDEEIVP-DFLGGPCKTMIHEGGLVPKTLYKMNSLEDHDDEVTAELPTTAAAQA 497
             |..|.:||.|:| ||           ||.:||          :|.:..||......|||
Human   284 -GFYQEIDENILPSDF-----------GGTLPK----------YDGKAVAEQLFGPQAQA 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retm	NP_001260132.1	PRELI	17..173	CDD:282550
		CRAL_TRIO_N	222..268	CDD:215024	17/56 (30%)
		CRAL_TRIO	293..456	CDD:279044	32/163 (20%)
RLBP1	XP_016877949.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1133487at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820