DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment retm and clvs2

DIOPT Version :9

Sequence 1:	NP_001260132.1	Gene:	retm / 33899	FlyBaseID:	FBgn0031814	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_001020716.1	Gene:	clvs2 / 566769	ZFINID:	ZDB-GENE-041014-313	Length:	329	Species:	Danio rerio

Alignment Length:	331	Identity:	72/331 - (21%)
Similarity:	131/331 - (39%)	Gaps:	68/331 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 ITHVERWTSPSDATKSPT-LDQASDQQHSILLDGDFIARSLGQLSPMQESKLLELRKMLDGVDDL 238
            :||::...||....|:.. |.:..|..|                     ..:.|:|.|:....|:
Zfish     1 MTHLQAGLSPETLEKAKVELKENPDTLH---------------------QDIQEVRDMIITRPDI 44

  Fly   239 ERVPSYQT-ILRFLAARDWHVSQAYAMLCDSLRWRREHRIDALLAEYSKPAV---VVEHFPGGWH 299
            ..:.:... |||||.||.::..:|:.:|.....:|:::.......:.:.|.:   :.:.|||...
Zfish    45 GFLRTDDAFILRFLRARKFNHFEAFRLLAQYFEYRQQNLDMFKNLKATDPGIKQALKDGFPGVLS 109

  Fly   300 HLDKDGRPVYILRLGHMDVK-----GLLKSLGMDGLLRLALHICEEGIQKINESAERLEKPVLNW 359
            :||:.||.:.:|...:.|..     .:|:::    ||.|...|            |..|..|..:
Zfish   110 NLDRYGRKILVLFAANWDQSRYTFVDILRAI----LLSLEAMI------------EDPELQVNGF 158

  Fly   360 SLLVDLEGLSMRHLWRPGIKALLNIIETVERNYPETMGRVLVVRAPRVFPIAWTIVSAFIDEHTR 424
            .|::|....:.:...:.....|...||.::.::|...|.:..|..|......:|::..|:.:.||
Zfish   159 VLIIDWSNFTFKQASKLTPSMLRLAIEGLQDSFPARFGGIHFVNQPWYIHALYTVIRPFLKDKTR 223

  Fly   425 SKFLFYGPDCAHMKDGLAQYLDEEIVPDFLGGPCKTMIHEGGLVPKTLYKM----NSLEDHD-DE 484
            .:...:|.:.    :.|.|.:..||:|..|          ||::|.  |.|    .:|.||. ||
Zfish   224 KRIFMHGNNL----NSLHQLILPEILPSEL----------GGMLPP--YDMGTWARTLLDHAYDE 272

  Fly   485 VTAELP 490
            .|...|
Zfish   273 ETDYCP 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retm	NP_001260132.1	PRELI	17..173	CDD:282550
		CRAL_TRIO_N	222..268	CDD:215024	13/46 (28%)
		CRAL_TRIO	293..456	CDD:279044	37/167 (22%)
clvs2	NP_001020716.1	CRAL_TRIO_N	29..75	CDD:215024	13/45 (29%)
		SEC14	106..251	CDD:238099	35/174 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..329
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810