DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment retm and sec14l8

DIOPT Version :9

Sequence 1:	NP_001260132.1	Gene:	retm / 33899	FlyBaseID:	FBgn0031814	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_001093463.1	Gene:	sec14l8 / 558964	ZFINID:	ZDB-GENE-060526-180	Length:	395	Species:	Danio rerio

Alignment Length:	414	Identity:	106/414 - (25%)
Similarity:	200/414 - (48%)	Gaps:	64/414 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 LGQLSPMQESKLLELRKMLDGVDDLERVPSYQT--ILRFLAARDWHVSQAYAMLCDSLRWRREHR 276
            :|.||..|...|.:.|:.:.  |.|.:.||...  :||:|.||::::.::.|||...:.:|:..:
Zfish     5 VGDLSVKQAEALAQFREKVQ--DVLPQCPSQSDHFLLRWLRARNFNLQKSEAMLRKHIEFRKHMK 67

  Fly   277 IDALLAEYSKPAVVVEHFPGGWHHLDKDGRPVYILRLGHMDVKGLLKSLGMDGLLRLALHICEEG 341
            :|.:..|:..|.|:.::..||....|::|.||:...:|.:|.|||:.|.....|::..:..||..
Zfish    68 VDTITTEWQVPEVIDKYLSGGMCGHDREGSPVWYDVIGPLDPKGLMHSASKQDLIKSKVRDCEIL 132

  Fly   342 IQKINESAERLEKPVLNWSLLVDLEGLSMRHLWRPGIKALLNIIETVERNYPETMGRVLVVRAPR 406
            .:..:..:|||.:.:.:.:::.|.|||.|:||::|.|:....::...|.||||.:.|:.|::||:
Zfish   133 QKDCDRQSERLGRNIESITMVYDCEGLGMKHLYKPAIETYGEVLTMFEDNYPEGLKRLFVIKAPK 197

  Fly   407 VFPIAWTIVSAFIDEHTRSKFLFYGPDCAHMKDGLAQYLDEEIVPDFLGG---------PCKTMI 462
            :||:|:.:|..|:.|.||.|.:..|   ::.::.|.:|:|.|.:|.:.||         .|:|.|
Zfish   198 LFPVAYNLVKHFLSEDTRRKVIVLG---SNWQEVLQKYIDPEELPAYYGGKLTDPDGDPKCRTRI 259

  Fly   463 HEGGLVPKTLYKMNSLE-DHDDEVTAELPTTAAAQALVPGKRLSANQQHDHRNLYKSVDLKAGFA 526
            ..|..:||:.|..:|:: |::                                  :||.:..|.:
Zfish   260 TFGSEIPKSYYVRDSIKVDYE----------------------------------QSVSIGRGSS 290

  Fly   527 HELLIRNEDPKSVLTWDFDVMRNDLHFTLYRVTQELPEKNDSAVSYFDLQDFVEGVNY----FRE 587
            |::......|...|.|.|.....|:.|.:|     |.:|....:...::::.|....|    ..|
Zfish   291 HQMEYELIAPNCALRWQFSCDGADIGFGVY-----LKKKMGERMKAGEMREIVPNQRYNAHLVPE 350

  Fly   588 EPTLICRHKESVQGSHVMHHNDSY 611
            :.:|.|..    .|.:|:..:::|
Zfish   351 DGSLTCPE----PGVYVLRFDNTY 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retm	NP_001260132.1	PRELI	17..173	CDD:282550
		CRAL_TRIO_N	222..268	CDD:215024	14/47 (30%)
		CRAL_TRIO	293..456	CDD:279044	51/162 (31%)
sec14l8	NP_001093463.1	CRAL_TRIO_N	13..59	CDD:215024	14/47 (30%)
		SEC14	78..246	CDD:214706	55/170 (32%)
		GOLD_2	304..382	CDD:290608	16/76 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1133487at2759
OrthoFinder	1	1.000	-	-		FOG0000197
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1304
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850