DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment retm and Ttpa

DIOPT Version :9

Sequence 1:	NP_001260132.1	Gene:	retm / 33899	FlyBaseID:	FBgn0031814	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_056582.1	Gene:	Ttpa / 50500	MGIID:	1354168	Length:	278	Species:	Mus musculus

Alignment Length:	259	Identity:	56/259 - (21%)
Similarity:	114/259 - (44%)	Gaps:	27/259 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 GDFIARSLGQL---SPMQESKLLELRKMLD--GVDDLERVPSYQTILRFLAARDWHVSQAYAMLC 266
            |..:.:.|.:|   ||:.:..|.|||:.:.  ||....:..:...:||||.|||:.:..|:.::.
Mouse     7 GPLVGKQLNELPDHSPLLQPGLAELRRRVQEAGVPQTPQPLTDAFLLRFLRARDFDLDLAWRLMK 71

  Fly   267 DSLRWRREHRIDALLAEYSKPAVVVEHFPGGWHHL----DKDGRPVYILRLGHMDVKGLLKSLGM 327
            :..:||.|  ...|.|:. :|..::.....|:|.:    |..|..|.|.|:.:.|.|.....
Mouse    72 NYYKWRAE--CPELSADL-RPRSILGLLKAGYHGVLRSRDSTGSRVLIYRIAYWDPKVFTAY--- 130

  Fly   328 DGLLRLALHICEEGIQKINESAERLEKPVLNWSLLVDLEGLSMRHLWRPGIKALLNIIETVERNY 392
             .:.|::|...|..:|::......::       .:.||||..:.|.::........|...:..::
Mouse   131 -DVFRVSLITSELIVQEVETQRNGVK-------AIFDLEGWQVSHAFQITPSVAKKIAAVLTDSF 187

  Fly   393 PETMGRVLVVRAPRVFPIAWTIVSAFIDEHTRSKFLFYGPDCAHMKDGLAQYLDEEIVPDFLGG 456
            |..:..:.::..|.:|...::::..|:.|..:.:...:|   .:.|..:.|:. .:|:|...||
Mouse   188 PLKVRGIHLINEPVIFHAVFSMIKPFLTEKIKDRIHLHG---NNYKSSMLQHF-PDILPREYGG 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retm	NP_001260132.1	PRELI	17..173	CDD:282550
		CRAL_TRIO_N	222..268	CDD:215024	14/47 (30%)
		CRAL_TRIO	293..456	CDD:279044	29/166 (17%)
Ttpa	NP_056582.1	CRAL_TRIO_N	25..73	CDD:215024	14/47 (30%)
		CRAL_TRIO	99..248	CDD:279044	31/164 (19%)
		Phosphatidylinositol 3,4-bisphosphate binding. /evidence=ECO:0000269\|PubMed:23599266, ECO:0007744\|PDB:3W67	190..192		0/1 (0%)
		Phosphatidylinositol 4,5-bisphosphate binding. /evidence=ECO:0000269\|PubMed:23599266, ECO:0007744\|PDB:3W68	208..211		0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810