DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment retm and sec14l5

DIOPT Version :9

Sequence 1:	NP_001260132.1	Gene:	retm / 33899	FlyBaseID:	FBgn0031814	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	XP_031749906.1	Gene:	sec14l5 / 493292	XenbaseID:	XB-GENE-953433	Length:	793	Species:	Xenopus tropicalis

Alignment Length:	739	Identity:	322/739 - (43%)
Similarity:	441/739 - (59%)	Gaps:	103/739 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVQKFQSPVRVYKYPFELVMKAYERRFPTCPQMPIVLDCEVIKDESLEDGAKRNTSRRCKLAVDA 65
            ||||:||||||||:.|||:|.||||||||||.:|:.:..:::.:...||||.....|||||.|||
Frog     1 MVQKYQSPVRVYKHGFELIMAAYERRFPTCPLIPMFVGSDLMNEYKSEDGAVHIVERRCKLDVDA 65

  Fly    66 PYIFKKLIGVDHVYFLQHNFLDLANRTLSIEAVNESFSSRIEIFERCRYYAHPDNSEWTCFDQSA 130
            |.:.||:.|||:|||:|.|.|:...|||.|||.||:|||||.:.|.|.|..||||..||||:|||
Frog    66 PRLLKKIAGVDYVYFIQKNSLNRQERTLHIEAYNETFSSRIIVNEHCCYTVHPDNENWTCFEQSA 130

  Fly   131 TLDIKNFFGFEHSMEKMGMKQYTQTTLKGKEIIEFFIGQLREEGITHVERWT---SPSDATKSPT 192
            :||||:|||||.::||:.|||||....|||||||:::.||.:||||.:.|||   :....||:.|
Frog   131 SLDIKSFFGFESTVEKIAMKQYTTNIKKGKEIIEYYLNQLEQEGITSMPRWTPEIAQRQETKTDT 195

  Fly   193 LDQASDQQHSI-------------------------------LLDGDFIARSLGQLSPMQESKLL 226
            ..:|.....||                               .||.|:|.|.||.|:|:|||.|:
Frog   196 SGRAMSPPQSIPTKSADGPSSKDGLPSSPTAATHELSSTPDDKLDADYIKRYLGDLTPLQESCLI 260

  Fly   227 ELRKMLDGVDDLERVPSYQTILRFLAARDWHVSQAYAMLCDSLRWRREHRIDALLAEYSKPAVVV 291
            .||:.|..... .::|..:.|||||.|||:::.:|..:||.||.||::|.:|.||:.:..|.|:.
Frog   261 RLRQWLQETHK-GKIPKDEHILRFLRARDFNIDKAREILCQSLTWRKQHHVDYLLSTWDPPQVLH 324

  Fly   292 EHFPGGWHHLDKDGRPVYILRLGHMDVKGLLKSLGMDGLLRLALHICEEGIQKINESAERLEKPV 356
            :::.|||||.|:||||:|:||||.||.|||:::||.:.|||..|.|.|||:::..|:.....:|:
Frog   325 DYYAGGWHHHDRDGRPLYVLRLGQMDTKGLVRALGEESLLRHVLSINEEGLRRCEENTNIFGRPI 389

  Fly   357 LNWSLLVDLEGLSMRHLWRPGIKALLNIIETVERNYPETMGRVLVVRAPRVFPIAWTIVSAFIDE 421
            .:|:.|||||||:||||||||:||||.|||.||.|||||:||:|::|||||||:.||:||.||||
Frog   390 SSWTCLVDLEGLNMRHLWRPGVKALLRIIEVVEANYPETLGRLLILRAPRVFPVLWTLVSPFIDE 454

  Fly   422 HTRSKFLFYGPDCAHMKDGLAQYLDEEIVPDFLGGPCKTMIHEGGLVPKTLYKM-NSLEDHDDEV 485
            :||.|||.|..:......||..|:|:|::||||||.|...:.|||:|||.||:. ..||:.|..:
Frog   455 NTRKKFLIYAGNDYQGPGGLIDYIDKEVIPDFLGGECMCEVSEGGMVPKALYRTPEELENDDIRL 519

  Fly   486 TAELPTTAAAQALVPGKRLSANQQHDHRNLYKSVDLKAGFAHELLIRNEDPKSVLTWDFDVMRND 550
            ..|                         .:|:|..:..|..||:||:..|..||:||||||.:.|
Frog   520 WTE-------------------------TIYQSASVFKGSPHEILIQIVDASSVITWDFDVCKGD 559

  Fly   551 LHFTLYRVTQELPE--KNDSA------------VSYFDLQDFVEGVNYFREEPTLICRHKESVQG 601
            :.|.:|. ::..|:  |.|:.            |...| :.:..|.:|...|..|||:..|||||
Frog   560 IVFNIYH-SKRAPQAPKRDTLGAHGITSPVGNNVQLID-KAWQLGRDYSMVESPLICKEGESVQG 622

  Fly   602 SHVMHHNDSYLMHW----------------------FSPSGAQLNVFY--EVLSSANYKGSMTSL 642
            |||......|::.|                      ...|..:..|.|  |::.|.:::||||||
Frog   623 SHVTRWPGFYILQWKFHSMPACATSSLPRVEDVLASLQVSSHKCKVMYYTEIIGSEDFRGSMTSL 687

  Fly   643 QSAFS--SNSSAASSVQSRXYEKA 664
            :|:.|  |..|||::..|:.:..:
Frog   688 ESSHSGFSQLSAATTSSSQSHSSS 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retm	NP_001260132.1	PRELI	17..173	CDD:282550	90/155 (58%)
		CRAL_TRIO_N	222..268	CDD:215024	18/45 (40%)
		CRAL_TRIO	293..456	CDD:279044	95/162 (59%)
sec14l5	XP_031749906.1	PRELI	17..173	CDD:398400	90/155 (58%)
		CRAL_TRIO_N	256..301	CDD:215024	18/45 (40%)
		CRAL_TRIO	326..490	CDD:395525	96/163 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	220	1.000	Domainoid score	I2571
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	593	1.000	Inparanoid score	I962
OMA	1	1.010	-	-		QHG49351
OrthoDB	1	1.010	-	-		D1133487at2759
OrthoFinder	1	1.000	-	-		FOG0000197
OrthoInspector	1	1.000	-	-		otm49140
Panther	1	1.100	-	-	O	PTHR23324
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X399
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080