DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment retm and sec14l1

DIOPT Version :9

Sequence 1:	NP_001260132.1	Gene:	retm / 33899	FlyBaseID:	FBgn0031814	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_957392.1	Gene:	sec14l1 / 394073	ZFINID:	ZDB-GENE-040426-801	Length:	697	Species:	Danio rerio

Alignment Length:	712	Identity:	316/712 - (44%)
Similarity:	437/712 - (61%)	Gaps:	81/712 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVQKFQSPVRVYKYPFELVMKAYERRFPTCPQMPIVLDCEVIKDESLEDGAKRNTSRRCKLAVDA 65
            ||||:|||||||||||||:|.||:|||||||.:|:.:..::|.:...||||:....|||.:.|:|
Zfish     1 MVQKYQSPVRVYKYPFELIMAAYDRRFPTCPLIPMFVKSDIINESHSEDGAELFIERRCTVDVEA 65

  Fly    66 PYIFKKLIGVDHVYFLQHNFLDLANRTLSIEAVNESFSSRIEIFERCRYYAHPDNSEWTCFDQSA 130
            |.:.|::.|||::||:|.|.|:...|||.|||.|||||||:.::|.|.|..||::.:||||:|||
Zfish    66 PRLLKRIAGVDYMYFIQKNSLNRRERTLHIEAYNESFSSRVNVYEHCCYTVHPESEDWTCFEQSA 130

  Fly   131 TLDIKNFFGFEHSMEKMGMKQYTQTTLKGKEIIEFFIGQLREEGITHVERWTSPS-----DATKS 190
            ::|||:|||||.:.||:.||||..:..||||||||.:.||.||||||:.||..|:     ..:.:
Zfish   131 SMDIKSFFGFESTAEKIAMKQYATSIKKGKEIIEFHLKQLEEEGITHMPRWVPPTAPQLIPVSSA 195

  Fly   191 PTLDQASDQQH-----------SILLDGDFIARSLGQLSPMQESKLLELRKMLDGVDDLERVPSY 244
            ..:...:.:.|           ...||.|:|:|.||.|:|.|||.|:.||:.|..... .::|..
Zfish   196 KPIPACTSRAHLGSTDVVPGSPDDKLDADYISRYLGTLTPFQESCLIRLRQWLQETHK-GKIPKD 259

  Fly   245 QTILRFLAARDWHVSQAYAMLCDSLRWRREHRIDALLAEYSKPAVVVEHFPGGWHHLDKDGRPVY 309
            |.:||||.:||:::.:|...||.:|.||::|:||.||..:..|..:.:::.|||||.||||||:|
Zfish   260 QHVLRFLRSRDFNLEKAKEALCQTLTWRKQHQIDFLLDTWQSPQPLQDYYTGGWHHHDKDGRPLY 324

  Fly   310 ILRLGHMDVKGLLKSLGMDGLLRLALHICEEGIQKINESAERLEKPVLNWSLLVDLEGLSMRHLW 374
            |||||.||.|||:::||.:.|||..|.|.|||:::..|:.:...||:..|:.|||||||:|||||
Zfish   325 ILRLGQMDTKGLVRALGEETLLRHVLSINEEGLRRCEENTKIFGKPISCWTCLVDLEGLNMRHLW 389

  Fly   375 RPGIKALLNIIETVERNYPETMGRVLVVRAPRVFPIAWTIVSAFIDEHTRSKFLFYGPDCAHMKD 439
            ||||||||.:||.|..|||||:||:|::|||||||:.||:||.||||:||.|||.|..:......
Zfish   390 RPGIKALLRMIEVVGANYPETLGRLLILRAPRVFPVLWTLVSPFIDENTRKKFLIYAGNDYQGPG 454

  Fly   440 GLAQYLDEEIVPDFLGGPCKTMIHEGGLVPKTLYK-MNSLEDHDDEVTAELPTTAAAQALVPGKR 503
            ||..|::::.:||||||.....|.|||||||:||: ...||:.:.::..|
Zfish   455 GLVDYINKDCIPDFLGGDSMCDIPEGGLVPKSLYRTAEELENEEVKLWNE--------------- 504

  Fly   504 LSANQQHDHRNLYKSVDLKAGFAHELLIRNEDPKSVLTWDFDVMRNDLHFTLY---RVTQELPEK 565
                      .:|||..:..|..||:||...|..||:||||||.:.|:.|.:|   |..|.:.::
Zfish   505 ----------TIYKSASVLKGAPHEVLIEITDVSSVITWDFDVCKGDMIFNIYHSRRAPQPVKKE 559

  Fly   566 NDSA----------VSYFDLQDFVEGVNYFREEPTLICRHKESVQGSHVMHHNDSYLMHW---FS 617
            ..||          |.:.| :.::.|.:|...|..|.||..||||||||......|::.|   .:
Zfish   560 GLSAHNLACPAGNNVQFID-RSWMLGQDYSMVETALTCREGESVQGSHVTRWPGFYILQWRLYST 623

  Fly   618 PSG------------AQLNV---------FYEVLSSANYKGSMTSLQSAFSSNSSAASSVQS 658
            ||.            |.|.|         |.|||.||:::|||:||:|:.|..|..::|..|
Zfish   624 PSCSSSSRPRVDDVLASLQVSSHRCKVMYFTEVLQSADFRGSMSSLESSHSGFSLLSASTTS 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retm	NP_001260132.1	PRELI	17..173	CDD:282550	82/155 (53%)
		CRAL_TRIO_N	222..268	CDD:215024	17/45 (38%)
		CRAL_TRIO	293..456	CDD:279044	95/162 (59%)
sec14l1	NP_957392.1	PRELI	17..173	CDD:282550	82/155 (53%)
		CRAL_TRIO_N	238..283	CDD:215024	17/45 (38%)
		CRAL_TRIO	308..472	CDD:279044	96/163 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	183	1.000	Domainoid score	I3368
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49351
OrthoDB	1	1.010	-	-		D1133487at2759
OrthoFinder	1	1.000	-	-		FOG0000197
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100867
Panther	1	1.100	-	-	O	PTHR23324
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X399
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.930