DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment retm and CG13893

DIOPT Version :9

Sequence 1:	NP_001260132.1	Gene:	retm / 33899	FlyBaseID:	FBgn0031814	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_612042.3	Gene:	CG13893 / 38074	FlyBaseID:	FBgn0035146	Length:	407	Species:	Drosophila melanogaster

Alignment Length:	396	Identity:	94/396 - (23%)
Similarity:	171/396 - (43%)	Gaps:	63/396 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 LGQLSPMQESKLLELRKMLDGVDDLERVPSYQTILRFLAARDWHVSQAYAMLCDSLRWRREHRID 278
            |.::|..|.:.|.:.||.:|  |.|........::|:|.||.|::..|..||..||:.|....:|
  Fly     5 LPEISEEQRAILEKFRKQMD--DALVGTHDDYFLVRWLRARKWNLEAAEKMLRASLKTRAMWNVD 67

  Fly   279 ALLAEYSKPAVVVEHFPGGWHHLDKDGRPVYILRLGHMDVKGLL---------KSLGMDGLLRLA 334
            . :.::..|..:.|:.|.|....|.:|.||.:....:.|:.|::         |.|.:  ||...
  Fly    68 N-IEKWDPPKALQEYLPYGLMGYDNEGSPVLVCPFANFDMWGMMHCVTRFEFQKYLVL--LLERF 129

  Fly   335 LHICEEGIQKINESAERLEKPVLNWSLLVDLEGLSMR-HLWRPGIKALLNIIETVERNYPETMGR 398
            :.|..:..||....|.:|       .:..|::.:::: :.|||..:.:::.::..|.|:||.:..
  Fly   130 MKIAYDQSQKHGWRARQL-------VVFFDMQDVNLKQYAWRPAAECVISTVKQYEANFPELLKM 187

  Fly   399 VLVVRAPRVFPIAWTIVSAFIDEHTRSKFLFYGPDCAHMKDGLAQYLDEEIVPDFLGG------- 456
            ..::.||::|.:|:.||..|:||:|.||.:.|.......::.|..:::.:..|...||
  Fly   188 CYIINAPKLFSVAFNIVKKFLDENTTSKIVIYKSGVDRWQEQLFSHVNRKAFPKAWGGEMVDRNG 252

  Fly   457 --PCKTMIHEGGLVPKTLYKMNSLEDHD-DEVTAELPTTAAAQALVPGKRLSANQQHDHRNLYKS 518
              .||.::..||.:|:.||...|.:..| |.|.|::|                          |.
  Fly   253 DPQCKALMVWGGKLPEELYIDQSSQQSDRDFVEAQVP--------------------------KG 291

  Fly   519 VDLKAGFAHELLIRNEDPKSVLTWDFDVMRNDLHFTLYRVTQELPEKNDSAVSYFDLQDFVEGVN 583
            ..||..|.     .|.:.:.:|:|:|.....|:.|.:|.|..:..||...........:.::.:.
  Fly   292 DKLKLHFK-----VNVEEQKILSWEFRTFDYDIKFGIYSVDDKTGEKRSEVPLGTVYSNEMDEIG 351

  Fly   584 YFREEP 589
            |....|
  Fly   352 YISTRP 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retm	NP_001260132.1	PRELI	17..173	CDD:282550
		CRAL_TRIO_N	222..268	CDD:215024	14/45 (31%)
		CRAL_TRIO	293..456	CDD:279044	40/172 (23%)
CG13893	NP_612042.3	CRAL_TRIO_N	16..57	CDD:215024	14/42 (33%)
		SEC14	75..246	CDD:238099	43/179 (24%)
		GOLD_2	303..381	CDD:290608	11/55 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456652
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	71	1.000	Inparanoid score	I2453
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1133487at2759
OrthoFinder	1	1.000	-	-		FOG0000197
OrthoInspector	1	1.000	-	-		mtm9225
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23324
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1304
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.930