DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment retm and Sec14l1

DIOPT Version :9

Sequence 1:	NP_001260132.1	Gene:	retm / 33899	FlyBaseID:	FBgn0031814	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_001101779.1	Gene:	Sec14l1 / 360668	RGDID:	1563123	Length:	720	Species:	Rattus norvegicus

Alignment Length:	738	Identity:	323/738 - (43%)
Similarity:	445/738 - (60%)	Gaps:	100/738 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVQKFQSPVRVYKYPFELVMKAYERRFPTCPQMPIVLDCEVIKDESLEDGAKRNTSRRCKLAVDA 65
            ||||:||||||||:||||:|.||||||||||.:|:.:|.:.:.:...||||.....|||||.:||
  Rat     1 MVQKYQSPVRVYKHPFELIMAAYERRFPTCPLIPMFVDSDTVSEFKSEDGAIHVIERRCKLDIDA 65

  Fly    66 PYIFKKLIGVDHVYFLQHNFLDLANRTLSIEAVNESFSSRIEIFERCRYYAHPDNSEWTCFDQSA 130
            |.:.||:.|||:|||:|.|.|:..:|||.|||.||:||:|:.|.|.|.|..||:|.:||||:|||
  Rat    66 PRLLKKIAGVDYVYFVQKNSLNSRDRTLHIEAHNETFSNRVIIHEHCCYTVHPENEDWTCFEQSA 130

  Fly   131 TLDIKNFFGFEHSMEKMGMKQYTQTTLKGKEIIEFFIGQLREEGITHVERWTSPSDATKSPTLDQ 195
            :||||:|||||.::||:.||.||....|||||||:::.||.|||||.|.|||.|.....|.|...
  Rat   131 SLDIKSFFGFESTVEKIAMKHYTSNIKKGKEIIEYYLRQLEEEGITFVPRWTPPPTGPSSETCSS 195

  Fly   196 ASDQQHSIL-----------------------------------LDGDFIARSLGQLSPMQESKL 225
            :.:|..|..                                   ||.|:|.|.||.|:|:|||.|
  Rat   196 SKNQAASAAVLVPDAAAVKEGLSGEVLSSPGTVAEPVVGTPDDKLDADYIKRYLGDLTPLQESCL 260

  Fly   226 LELRKMLDGVDDLERVPSYQTILRFLAARDWHVSQAYAMLCDSLRWRREHRIDALLAEYSKPAVV 290
            :.||:.|..... .::|..:.|||||.|||:::.:|..::|.||.||::|::|.:|..::.|.|:
  Rat   261 IRLRQWLQETHK-GKIPKDEHILRFLRARDFNIDKAREIMCQSLTWRKQHQVDYILDTWTPPQVL 324

  Fly   291 VEHFPGGWHHLDKDGRPVYILRLGHMDVKGLLKSLGMDGLLRLALHICEEGIQKINESAERLEKP 355
            .:::.|||||.||||||:|:||||.||.|||:::||.:.|||..|.|.|||:::..|:.:...:|
  Rat   325 QDYYAGGWHHHDKDGRPLYVLRLGQMDTKGLVRALGEEALLRYVLSINEEGLRRCEENTKVFGRP 389

  Fly   356 VLNWSLLVDLEGLSMRHLWRPGIKALLNIIETVERNYPETMGRVLVVRAPRVFPIAWTIVSAFID 420
            :.:|:.|||||||:||||||||:||||.|||.||.|||||:||:|::|||||||:.||:||.|||
  Rat   390 ISSWTCLVDLEGLNMRHLWRPGVKALLRIIEVVEANYPETLGRLLILRAPRVFPVLWTLVSPFID 454

  Fly   421 EHTRSKFLFYGPDCAHMKDGLAQYLDEEIVPDFLGGPCKTMIHEGGLVPKTLYKM-NSLEDHDDE 484
            ::||.|||.|..:......||..|:|:||:||||.|.|...:.|||||||:||:. ..||:.|.:
  Rat   455 DNTRRKFLIYAGNDYQGPGGLLDYIDKEIIPDFLSGECMCDVPEGGLVPKSLYRTPEELENEDLK 519

  Fly   485 VTAELPTTAAAQALVPGKRLSANQQHDHRNLYKSVDLKAGFAHELLIRNEDPKSVLTWDFDVMRN 549
            :..|                         .:|:|..:..|..||:||:..|..||:||||||.:.
  Rat   520 LWTE-------------------------TIYQSASVFKGAPHEILIQIVDAASVITWDFDVCKG 559

  Fly   550 DLHFTLYRVTQE-LPEKNDSAVSY---------FDLQDFV--EGVNYFREEPTLICRHKESVQGS 602
            |:.|.:|...:. .|.|.||..::         ..|.|.|  .|.:|...|..|||:..||||||
  Rat   560 DIVFNIYHSKRSPQPPKKDSLGAHSITSPGGNNVQLIDKVWQLGRDYSMVESPLICKEGESVQGS 624

  Fly   603 HVMHHNDSYLMHW---FSPSGAQLNV---------------------FYEVLSSANYKGSMTSLQ 643
            ||......|::.|   ..|:.|..|:                     :.||:.|.:::||||||:
  Rat   625 HVTRWPGFYILQWKFHTMPACAATNLPRVDDVLASLQVSSHKCKVMYYTEVIGSEDFRGSMTSLE 689

  Fly   644 SAFS--SNSSAASSVQSRXYEKA 664
            |:.|  |..|||::..|: :..:
  Rat   690 SSHSGFSQLSAATTSSSQSHSSS 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retm	NP_001260132.1	PRELI	17..173	CDD:282550	87/155 (56%)
		CRAL_TRIO_N	222..268	CDD:215024	17/45 (38%)
		CRAL_TRIO	293..456	CDD:279044	96/162 (59%)
Sec14l1	NP_001101779.1	PRELI	17..173	CDD:282550	87/155 (56%)
		CRAL_TRIO_N	257..302	CDD:215024	17/45 (38%)
		CRAL_TRIO	327..491	CDD:279044	96/163 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	218	1.000	Domainoid score	I2571
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	593	1.000	Inparanoid score	I938
OMA	1	1.010	-	-		QHG49351
OrthoDB	1	1.010	-	-		D1133487at2759
OrthoFinder	1	1.000	-	-		FOG0000197
OrthoInspector	1	1.000	-	-		otm46053
orthoMCL	1	0.900	-	-		OOG6_100867
Panther	1	1.100	-	-	O	PTHR23324
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X399
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840