DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment retm and SEC14L2

DIOPT Version :9

Sequence 1:	NP_001260132.1	Gene:	retm / 33899	FlyBaseID:	FBgn0031814	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_036561.1	Gene:	SEC14L2 / 23541	HGNCID:	10699	Length:	403	Species:	Homo sapiens

Alignment Length:	439	Identity:	117/439 - (26%)
Similarity:	204/439 - (46%)	Gaps:	81/439 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 LGQLSPMQESKLLELRKMLDGVDDLERVPSYQTILRFLAARDWHVSQAYAMLCDSLRWRREHRID 278
            :|.|||.|:..|.:.|:.:..|......|....:||:|.||.:.:.::.|||...:.:|::..||
Human     5 VGDLSPRQKEALAKFRENVQDVLPALPNPDDYFLLRWLRARSFDLQKSEAMLRKHVEFRKQKDID 69

  Fly   279 ALLAEYSKPAVVVEHFPGGWHHLDKDGRPVYILRLGHMDVKGLLKSLGMDGLLRLALHICEEGIQ 343
            .::: :..|.|:.::..||....|.||.||:...:|.:|.||||.|.....|||..:..||..:|
Human    70 NIIS-WQPPEVIQQYLSGGMCGYDLDGCPVWYDIIGPLDAKGLLFSASKQDLLRTKMRECELLLQ 133

  Fly   344 KINESAERLEKPVLNWSLLVDLEGLSMRHLWRPGIKALLNIIETVERNYPETMGRVLVVRAPRVF 408
            :......:|.:.|...:::.|.|||.::|||:|.::|....:...|.|||||:.|:.||:||::|
Human   134 ECAHQTTKLGRKVETITIIYDCEGLGLKHLWKPAVEAYGEFLCMFEENYPETLKRLFVVKAPKLF 198

  Fly   409 PIAWTIVSAFIDEHTRSKFLFYGPDCAHMKDGLAQYLDEEIVPDFLGG---------PCKTMIHE 464
            |:|:.::..|:.|.||.|.:..|   |:.|:.|.:::..:.||...||         .||:.|:.
Human   199 PVAYNLIKPFLSEDTRKKIMVLG---ANWKEVLLKHISPDQVPVEYGGTMTDPDGNPKCKSKINY 260

  Fly   465 GGLVPKTLYKMNSLEDHDDEVTAELPTTAAAQALVPGKRLSANQQHDHRNLYKSVDLKAGFAHEL 529
            ||.:|:..|..:.::                            ||::|     ||.:..|.:|::
Human   261 GGDIPRKYYVRDQVK----------------------------QQYEH-----SVQISRGSSHQV 292

  Fly   530 LIRNEDPKSVLTWDFDVMRNDLHFTLY------------RVTQELPEKNDSAVSYFDLQDFVEGV 582
            ......|..||.|.|.....|:.|.::            .:|:.||.:..::
Human   293 EYEILFPGCVLRWQFMSDGADVGFGIFLKTKMGERQRAGEMTEVLPNQRYNS------------- 344

  Fly   583 NYFREEPTLICRHKESVQGSHVMHHNDSY-LMHWFSPSGAQLNVFYEVL 630
            :...|:.||.|    |..|.:|:..:::| .:|     ..::|...|||
Human   345 HLVPEDGTLTC----SDPGIYVLRFDNTYSFIH-----AKKVNFTVEVL 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retm	NP_001260132.1	PRELI	17..173	CDD:282550
		CRAL_TRIO_N	222..268	CDD:215024	12/45 (27%)
		CRAL_TRIO	293..456	CDD:279044	56/162 (35%)
SEC14L2	NP_036561.1	CRAL_TRIO_N	13..59	CDD:215024	12/45 (27%)
SEC14L2	NP_036561.1	SEC14	76..244	CDD:214706	59/170 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151939
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1133487at2759
OrthoFinder	1	1.000	-	-		FOG0000197
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1304
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.780