DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment retm and F20G2.3

DIOPT Version :9

Sequence 1:	NP_001260132.1	Gene:	retm / 33899	FlyBaseID:	FBgn0031814	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_506408.1	Gene:	F20G2.3 / 179870	WormBaseID:	WBGene00008987	Length:	377	Species:	Caenorhabditis elegans

Alignment Length:	413	Identity:	88/413 - (21%)
Similarity:	156/413 - (37%)	Gaps:	115/413 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 MQESKLLELRKMLDGVDDLERVPSYQT---ILRFLAARDWHVSQAYAMLCDSLRWRR-EHRIDAL 280
            :.||..:.:.::.:.|.: ...|.|.|   :||:|...|:.:......|.:.|.:|: :..:|:|
Worm     3 ISESDRVAINELREAVKE-HLTPYYDTDFNLLRWLKGHDYKMDVIKPKLINHLLFRKSDWDLDSL 66

  Fly   281 LAEYSKPAVVVEHFPGGWHHLDKDGRP----------VYILRLGHMDVKGLLKSLGMDGLLRLAL 335
            .   .||.   :|   ..||..|.|..          |.|.:.|..|..|:|.|...:.:||..:
Worm    67 A---DKPR---DH---PVHHHWKTGLTGESGIIPNTIVNIEQTGSNDYWGMLHSYPTNEILRARV 122

  Fly   336 HICEEGIQKINESAERLEKPV---LNWSLLVDLEGLSMRH----LWRPGIKALLNIIETVERNYP 393
            |..|..::.:.:    |||..   .:...::||.|:....    |...|:.|   |...:..:|.
Worm   123 HDLESMLKAVMD----LEKKTNQQCSVIYIMDLTGIKFDKRTITLLTGGLSA---ISAFMAEHYV 180

  Fly   394 ETMGRVLVVRAPRVFPIAWTIVSAFIDEHTRSKFLFYGPDCAHMKDGLAQYLDEEIVPDFLGGPC 458
            |.:...::|..|......|||....:.|.||:|               ...|:.|...:.|
Worm   181 ELVHSFVLVNVPAFISAIWTIAKPLLPERTRNK---------------CNILNSEWRVEVL---- 226

  Fly   459 KTMIHEGGLVPKTLYKMNSLEDHDDEVTAELPTTAAAQALVP--------GKRLSANQQHDHRNL 515
              .:.||..:|      :...|.:|:.    |.||..:..||        || :|:|.  ||.::
Worm   227 --KMAEGSCLP------SYWNDEEDDG----PFTAPIEKCVPFPEDKYYMGK-VSSNA--DHMSV 276

  Fly   516 ------YKSVDLKAGFAHELLIRNEDPKSVLTWDFDVMRNDLH--FTLYRVTQELPEKNDSAVSY 572
                  :..|::|.|             ..|:|:   :.::.|  |.:|.:.. :|..:|...:|
Worm   277 SAGKTGFVEVEVKTG-------------QTLSWE---IHSNGHFAFAIYELPL-VPNNSDDVSNY 324

  Fly   573 ---FDLQDFVEGVNYFREEPTLI 592
               :.|...:.|       ||::
Worm   325 TRVYPLFSKIPG-------PTIV 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retm	NP_001260132.1	PRELI	17..173	CDD:282550
		CRAL_TRIO_N	222..268	CDD:215024	11/48 (23%)
		CRAL_TRIO	293..456	CDD:279044	40/179 (22%)
F20G2.3	NP_506408.1	SEC14	72..243	CDD:214706	44/207 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1133487at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920