DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment retm and T03F7.7

DIOPT Version :9

Sequence 1:	NP_001260132.1	Gene:	retm / 33899	FlyBaseID:	FBgn0031814	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_872173.1	Gene:	T03F7.7 / 179564	WormBaseID:	WBGene00011404	Length:	394	Species:	Caenorhabditis elegans

Alignment Length:	375	Identity:	70/375 - (18%)
Similarity:	138/375 - (36%)	Gaps:	107/375 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 FIARSL----GQLSPMQES--KLLELRKMLDGVDDLERVPSYQTILRFLAARD----WHVSQA-Y 262
            |.||.|    |.:...::.  :|.|.||:: |.:.:..:..:.|:   ...:|    :|:||. |
Worm    38 FFARFLNANNGDVEKTRQKIIQLFEHRKLM-GYEKINDLDIFTTV---NIGKDCFERFHISQLNY 98

  Fly   263 AMLCDSLRWRREHRIDALLAEYSKPAVVVEHFPGGWHHLDKDGRPVYILRLGHMDVKGLLKSLGM 327
            .:...:|.                                     |::.::...|:|.:||.:.:
Worm    99 EVTSKNLH-------------------------------------VFVQKMEGTDIKEILKVMPL 126

  Fly   328 DGLLRLALHICEEGIQKINESAERLEKPVLNWSLLVDLEGLSMRHLWRP--GIKALLNIIETVER 390
            ..:|. :..:.:|...:.....||......:...::||:||::.....|  |...|..::..|..
Worm   127 SYVLH-SYFMLQENFSRAMAHTERKTGKTSSVVCILDLKGLNLMDFMNPLSGPAQLARLVVQVWA 190

  Fly   391 NY-PETMGRVLVVRAPRVFPIAWTIVSAFIDEHTRSKFLFYGPDCAHMKDGLAQYLDEEIVPDFL 454
            .| .|.:.::|::..|.:..:.|.:....:|.:|..|..|    .::::| |.:||:.|.:|...
Worm   191 EYFSEHLCKLLLINPPGIISVMWQVTKRLVDPNTVEKLAF----LSNVED-LKKYLEPEAIPVEY 250

  Fly   455 GGPCKTMIHEGGLVPKTLYKMNSLEDHDDEVTAELPTTAAAQALVPGKRLSANQQHDHRNLY--- 516
            ||..:                      ||...|:.|..|..|.    ||::.........::
Worm   251 GGTYR----------------------DDTGYADPPEGACKQP----KRITKEDYKPQEYIWVKN 289

  Fly   517 --------KSVDLKAGFAHELLIRNEDPKSVLTW--------DFDVMRND 550
                    ||..:||....|.:|:. ..:..|.|        ||::::.|
Worm   290 GILKAPKGKSYSIKAFQTSEYIIKT-TTEGKLVWNYTTSGDVDFEIVKRD 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retm	NP_001260132.1	PRELI	17..173	CDD:282550
		CRAL_TRIO_N	222..268	CDD:215024	11/52 (21%)
		CRAL_TRIO	293..456	CDD:279044	32/165 (19%)
T03F7.7	NP_872173.1	SEC14	85..254	CDD:214706	40/211 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2121
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000197
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.860