DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment retm and T23G5.2

DIOPT Version :9

Sequence 1:	NP_001260132.1	Gene:	retm / 33899	FlyBaseID:	FBgn0031814	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_001040875.1	Gene:	T23G5.2 / 176302	WormBaseID:	WBGene00011962	Length:	719	Species:	Caenorhabditis elegans

Alignment Length:	729	Identity:	305/729 - (41%)
Similarity:	435/729 - (59%)	Gaps:	102/729 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVQKFQSPVRVYKYPFELVMKAYERRFPTCPQMPIVLDCEVIKDESLEDGAKRNTSRRCKLAVDA 65
            |||.::||||:||:|||:||.|||.|||||||:||.:..||..:....|||:....|:|:|.|:|
Worm     1 MVQTYRSPVRIYKHPFEIVMAAYEMRFPTCPQIPIFVGSEVTYEYKSVDGAEWVIDRKCQLNVEA 65

  Fly    66 PYIFKKLIGVDHVYFLQHNFLDLANRTLSIEAVNESFSSRIEIFERCRYYAHPDNSEWTCFDQSA 130
            ||:.||:.|||:|||.|.|.||...|||.|||.|.||||||.:.|.|.||.|.:|..||||:|||
Worm    66 PYLVKKIAGVDYVYFSQKNSLDRRKRTLDIEATNISFSSRINVKENCTYYVHAENENWTCFEQSA 130

  Fly   131 TLDIKNFFGFEHSMEKMGMKQYTQTTLKGKEIIEFFIGQLREEGITHVERW--------TSPSDA 187
            :||:|||||.|.::||:.::||.....|||||:||||.:|.:: .||:||:        ||.:|:
Worm   131 SLDVKNFFGLESAVEKLAVRQYGANLAKGKEILEFFIEELLKK-TTHIERFRDADQEETTSATDS 194

  Fly   188 T----------------KSPTLDQASDQQHSI-----------LLDGDFIARSLGQLSPMQESKL 225
            .                :.|.|...:|:..:.           .|:.::|.|.||||||::||:|
Worm   195 AIEMKELSDGDAVLVNDRPPMLAAETDEMRTARATASFDDADSKLEAEYIRRFLGQLSPLEESRL 259

  Fly   226 LELRKMLDGVDDLERVPSYQTILRFLAARDWHVSQAYAMLCDSLRWRREHRIDALLAEYSKPAVV 290
            .|::..|. .....::|:...:||||.|||:.|::|..|:..|:.||::|.:|.:|.|:::|.|:
Worm   260 CEIKYSLQ-AHHKGKLPNDAHLLRFLRARDFDVAKAKDMVHASIIWRKQHNVDKILEEWTRPTVI 323

  Fly   291 VEHFPGGWHHLDKDGRPVYILRLGHMDVKGLLKSLGMDGLLRLALHICEEGIQKINESAERLEKP 355
            .::|||.||:.||.|||:||||.|.:|.||:|:|.|::.|::|.|.|||:|:|:..|:..:|..|
Worm   324 KQYFPGCWHNSDKAGRPMYILRFGQLDTKGMLRSCGVENLVKLTLSICEDGLQRAAEATRKLGTP 388

  Fly   356 VLNWSLLVDLEGLSMRHLWRPGIKALLNIIETVERNYPETMGRVLVVRAPRVFPIAWTIVSAFID 420
            :.:|||:|||:|||||||||||::.||.|||.||.|||||||:|||||||||||:.||::|.|||
Worm   389 ISSWSLVVDLDGLSMRHLWRPGVQCLLKIIEIVEANYPETMGQVLVVRAPRVFPVLWTLISPFID 453

  Fly   421 EHTRSKFLFYGPDCAHMKDGLAQYLDEEIVPDFLGGPC-KTMIHEGGLVPKTLYKMNSLEDHDDE 484
            |.||.||:..|.....:|:.|.::::|:.:||||||.| .|....||.|||::|.  .:|:.:..
Worm   454 EKTRKKFMVSGGSGGDLKEELRKHIEEKFIPDFLGGSCLTTNCGLGGHVPKSMYL--PVEEQEGA 516

  Fly   485 VTAELPTTAAAQALVPGKRLSANQQHDHRNLYKSVDLKAGFAHELLIRNEDPKSVLTWDFDVMRN 549
            .::|.|.                     .:.|.|.....|:..|::|..|....||||||||::|
Worm   517 SSSEDPL---------------------HSTYTSTATWRGYPVEVVIPIETAGCVLTWDFDVLKN 560

  Fly   550 DLHFTLYRVTQ--ELPEKNDSAVS---------------------YFDLQDFVE---GVNYFR-E 587
            |..|:||..|:  |.|...|.|.|                     :.|||...|   |....| |
Worm   561 DCEFSLYFSTEKIEQPAVRDGAQSPTTILNPVEMVSAAIGGASHQHPDLQCAPELKIGTPQLRLE 625

  Fly   588 EPTLICRHKESVQGSHVMHHNDSYLMHWFSPSGA--------------QLNVFYEVLSSANYKGS 638
            |..::.:..:|:||||......:|:|.|..|..|              :|..:||:|:|.|::||
Worm   626 EKAVVFQEGDSMQGSHYCSRAGTYIMQWRVPETAAGHSSTFDFGSHKCRLIYYYEILNSENFRGS 690

  Fly   639 MTSLQSAFSSNSSA 652
            :.||:|..||:.|:
Worm   691 VASLESCRSSSFSS 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retm	NP_001260132.1	PRELI	17..173	CDD:282550	87/155 (56%)
		CRAL_TRIO_N	222..268	CDD:215024	16/45 (36%)
		CRAL_TRIO	293..456	CDD:279044	93/162 (57%)
T23G5.2	NP_001040875.1	PRELI	17..170	CDD:282550	86/152 (57%)
		CRAL_TRIO_N	256..297	CDD:215024	15/41 (37%)
		SEC14	320..491	CDD:214706	97/170 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166830
Domainoid	1	1.000	217	1.000	Domainoid score	I1554
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	543	1.000	Inparanoid score	I634
Isobase	1	0.950	-	0	Normalized mean entropy	S2121
OMA	1	1.010	-	-		QHG49351
OrthoDB	1	1.010	-	-		D1133487at2759
OrthoFinder	1	1.000	-	-		FOG0000197
OrthoInspector	1	1.000	-	-		oto19167
orthoMCL	1	0.900	-	-		OOG6_100867
Panther	1	1.100	-	-	LDO	PTHR23324
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1304
SonicParanoid	1	1.000	-	-		X399
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.890