DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment retm and ctg-2

DIOPT Version :9

Sequence 1:	NP_001260132.1	Gene:	retm / 33899	FlyBaseID:	FBgn0031814	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_001254156.1	Gene:	ctg-2 / 174360	WormBaseID:	WBGene00011756	Length:	408	Species:	Caenorhabditis elegans

Alignment Length:	403	Identity:	95/403 - (23%)
Similarity:	171/403 - (42%)	Gaps:	69/403 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 LDGDFIARSLGQLSPMQESKLLELRKMLDGVDDLERVPSYQ---TILRFLAARDWHVSQAYAMLC 266
            |.|:.::.|.|:::......|.||||.:.  .:||.|..|.   :::|:|...|..:......:.
Worm     8 LSGERMSTSTGEITESDRKLLDELRKRIH--KELELVKEYDDDFSLMRWLIGWDRKIDVVVPKIK 70

  Fly   267 DSLRWRREHRIDAL------LAEYSKPA-------VVVEHFPGGWHHLDKDGRPVYILRLGHMDV 318
            .|||     .|.||      |:...|.|       |.:.:.||....||.:...|.:..:||:|.
Worm    71 FSLR-----AIHALGLDQEDLSTLEKVAQKCDDCSVPLRYLPGSLIGLDHENNVVSLQMIGHLDA 130

  Fly   319 KGLLKSLGMDGLLRLALHICE-EGIQKINESAERLEKPVLNWSLLVDLEGLSMRHLWRPGIKALL 382
            .||:.:.....|.|  :.|.| ||:.:|....|:.:...|..|::.||:||||..:....:|.:.
Worm   131 AGLMPATRNSDLYR--MRIAESEGVMQIIRKMEKEQGKPLGTSVIFDLDGLSMVQIDLAALKVVT 193

  Fly   383 NIIETVERNYPETMGRVLVVRAPRVFPIAWTIVSAFIDEHTRSKFLFYGPDCAHMKDGLAQYLDE 447
            .::..::..:|:.:.::.:|..|....:.|:::|..:.:.|:.|....|.|   .|..|.:.:.|
Worm   194 TMLSQLQEMFPDVIRKIFIVNTPTFIQVLWSMISPCLAKQTQQKVKILGND---WKQHLKENIGE 255

  Fly   448 EIVPDFLGGPCKT-----MIHEGGLVPKTLYKMNSLEDHDDEVTAELPTTAAAQALVPGKRLSAN 507
            |::.:..||..|.     .:..||.:|..| |.:...|...|...:|..:|.:...||
Worm   256 EVLFERWGGTRKAETEYGNVRMGGKIPAEL-KYDPANDLPAEKLTKLNVSARSTTFVP------- 312

  Fly   508 QQHDHRNLYKSVDLKAGFAHELLIRNEDPKSVLTWDFDVMRNDLHFTLYRVT---QELPEKNDSA 569
                                 :.:....|...|.|.:.:..||::|::.|..   :::.|.:|..
Worm   313 ---------------------ITLEGNVPGRKLYWWWRLENNDINFSILRAAEGEEKVAEHDDDY 356

  Fly   570 VSY--FDLQ-DFV 579
            :.:  |.|| |||
Worm   357 MVHPKFKLQTDFV 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retm	NP_001260132.1	PRELI	17..173	CDD:282550
		CRAL_TRIO_N	222..268	CDD:215024	12/48 (25%)
		CRAL_TRIO	293..456	CDD:279044	40/163 (25%)
ctg-2	NP_001254156.1	SEC14	98..267	CDD:214706	43/173 (25%)
ctg-2	NP_001254156.1	EMP24_GP25L	331..>405	CDD:279450	12/39 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1133487at2759
OrthoFinder	1	1.000	-	-		FOG0000197
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920