DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment retm and CLVS1

DIOPT Version :9

Sequence 1:	NP_001260132.1	Gene:	retm / 33899	FlyBaseID:	FBgn0031814	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_775790.1	Gene:	CLVS1 / 157807	HGNCID:	23139	Length:	354	Species:	Homo sapiens

Alignment Length:	393	Identity:	84/393 - (21%)
Similarity:	157/393 - (39%)	Gaps:	85/393 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 ITHVERWTSPSDATKSP-TLDQASDQQHSILLDGDFIARSLGQLSPMQESKLLELRKMLDGVDDL 238
            :||::...||....|:. .|::..|..|                     ..:.::|.|:....|:
Human    23 MTHLQAGLSPETIEKARLELNENPDVLH---------------------QDIQQVRDMIITRPDI 66

  Fly   239 ERVPSYQT-ILRFLAARDWHVSQAYAMLCDSLRWR-------REHRIDALLAEYSKPAV---VVE 292
            ..:.:... |||||.||.:|.:.|:.:|....::|       :..:.|       .|.:   :::
Human    67 GFLRTDDAFILRFLRARKFHQADAFRLLAQYFQYRQLNLDMFKNFKAD-------DPGIKRALID 124

  Fly   293 HFPGGWHHLDKDGRPVYILRLGHMD-----VKGLLKSLGMDGLLRLALHICEEGIQKINESAERL 352
            .|||...:.|..||.:.:|...:.|     ...:|:::    ||.|.:.|.:..:| ||
Human   125 GFPGVLENRDHYGRKILLLFAANWDQSRNSFTDILRAI----LLSLEVLIEDPELQ-IN------ 178

  Fly   353 EKPVLNWSLLVDLEGLSMRHLWR--PGIKALLNIIETVERNYPETMGRVLVVRAPRVFPIAWTIV 415
                 .:.|::|....|.:...:  |.|..|  .||.::.::|...|.|..|..|......:|::
Human   179 -----GFILIIDWSNFSFKQASKLTPSILKL--AIEGLQDSFPARFGGVHFVNQPWYIHALYTLI 236

  Fly   416 SAFIDEHTRSKFLFYGPDCAHMKDGLAQYLDEEIVPDFLGGPCKTMIHEGGLVPKTLYKMNSLED 480
            ..|:.:.||.:...:|.:.    :.|.|.:..|.:|...||....  ::.|...:||...:..::
Human   237 KPFLKDKTRKRIFLHGNNL----NSLHQLIHPEFLPSEFGGTLPP--YDMGTWARTLLGPDYSDE 295

  Fly   481 HDDEVTAELPTTAAAQALVPGKRLSANQQHD-HRNLYK---SVDLKAG-FAHELLIRNEDPKSVL 540
            :|        .|..:...:..|..|:|.:.: ...|.|   || ::|| ..||....||:.:.:|
Human   296 ND--------YTHTSYNAMHVKHTSSNLERECSPKLMKRSQSV-VEAGTLKHEEKGENENTQPLL 351

  Fly   541 TWD 543
            ..|
Human   352 ALD 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retm	NP_001260132.1	PRELI	17..173	CDD:282550
		CRAL_TRIO_N	222..268	CDD:215024	13/46 (28%)
		CRAL_TRIO	293..456	CDD:279044	38/169 (22%)
CLVS1	NP_775790.1	CRAL_TRIO_N	51..97	CDD:215024	13/45 (29%)
		CRAL_TRIO	125..274	CDD:306996	39/170 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..354		7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810