DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment retm and CLVS2

DIOPT Version :9

Sequence 1:	NP_001260132.1	Gene:	retm / 33899	FlyBaseID:	FBgn0031814	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_001010852.2	Gene:	CLVS2 / 134829	HGNCID:	23046	Length:	327	Species:	Homo sapiens

Alignment Length:	369	Identity:	81/369 - (21%)
Similarity:	153/369 - (41%)	Gaps:	74/369 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 ITHVERWTSPSDATKSP-TLDQASDQQHSILLDGDFIARSLGQLSPMQESKLLELRKMLDGVDDL 238
            :||::...||....|:. .|::..|..|                     ..:.|:|.|:....|:
Human     1 MTHLQAGLSPETLEKARLELNENPDTLH---------------------QDIQEVRDMVITRPDI 44

  Fly   239 ERVPSYQT-ILRFLAARDWHVSQAYAMLCDSLRWRREHRIDALLA-EYSKPAV---VVEHFPGGW 298
            ..:.:... |||||.||.:|..:|:.:|.....:|::: :|...: :.:.|.:   :.:.||||.
Human    45 GFLRTDDAFILRFLRARKFHHFEAFRLLAQYFEYRQQN-LDMFKSFKATDPGIKQALKDGFPGGL 108

  Fly   299 HHLDKDGRPVYILRLGHMD-----VKGLLKSLGMDGLLRLALHICEEGIQKINESAERLEKPVLN 358
            .:||..||.:.:|...:.|     :..:|:::    ||.|...|            |..|..|..
Human   109 ANLDHYGRKILVLFAANWDQSRYTLVDILRAI----LLSLEAMI------------EDPELQVNG 157

  Fly   359 WSLLVDLEGLSMRHLWRPGIKALLNIIETVERNYPETMGRVLVVRAPRVFPIAWTIVSAFIDEHT 423
            :.|::|....:.:...:.....|...||.::.::|...|.:..|..|......:|::..|:.|.|
Human   158 FVLIIDWSNFTFKQASKLTPSMLRLAIEGLQDSFPARFGGIHFVNQPWYIHALYTVIRPFLKEKT 222

  Fly   424 RSKFLFYGPDCAHMKDGLAQYLDEEIVPDFLGGPCKTMI--HEGGLVPKTL----------YKMN 476
            |.:...:|.:.    :.|.|.:..||:|...||    |:  ::.|...:||          |.::
Human   223 RKRIFLHGNNL----NSLHQLIHPEILPSEFGG----MLPPYDMGTWARTLLDHEYDDDSEYNVD 279

  Fly   477 SLEDHDDEVTAEL--PTTAAAQALVPG---KRLSANQQHDHRNL 515
            |......||..||  .:...:|::|..   ||:..|::.:.:.|
Human   280 SYSMPVKEVEKELSPKSMKRSQSVVDPTVLKRMDKNEEENMQPL 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
retm	NP_001260132.1	PRELI	17..173	CDD:282550
		CRAL_TRIO_N	222..268	CDD:215024	14/46 (30%)
		CRAL_TRIO	293..456	CDD:279044	38/167 (23%)
CLVS2	NP_001010852.2	CRAL_TRIO_N	29..75	CDD:215024	14/45 (31%)
		SEC14	106..251	CDD:238099	36/164 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..327		10/37 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810