DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9527 and Acox2

DIOPT Version :9

Sequence 1:	NP_001137800.1	Gene:	CG9527 / 33898	FlyBaseID:	FBgn0031813	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_001155139.1	Gene:	Acox2 / 93732	MGIID:	1934852	Length:	681	Species:	Mus musculus

Alignment Length:	763	Identity:	225/763 - (29%)
Similarity:	346/763 - (45%)	Gaps:	143/763 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GDGGDQNGLNSLLTALGDYYSGRREEKAAANIYDDKRIFPDFRSGPLEEYRERASFCYKRMNVVL 72
            |:.||:       .:||:.:|              :.:.||     ::..|...||..:|:..:|
Mouse     2 GNPGDR-------VSLGETWS--------------REVHPD-----IDSERHSPSFSVERLTNIL 40

  Fly    73 EGE-DHIRLKHKVWQWMEQHPDYQREPGSDLER----TR-----EMANKRQH---LLWE------ 118
            :|. .:..|:.:|...:      ||:|..:|:.    ||     :...||.|   |.|.
Mouse    41 DGGIPNTELRRRVESLI------QRDPVFNLKHLYFMTRDELYEDAVQKRFHLEKLAWSLGWSED 99

  Fly   119 --QQFYGVNEYLGTPHLLLAFGQAIFSYDFSTSVKFGLSTGMFPSTLVSNGS-------GRLGKY 174
              ::.|......|..:|.|                    .|:..:.:.|.||       |:|||
Mouse   100 GPERIYADRVLAGYNNLNL--------------------HGIAMNAIRSLGSDEQIAKWGQLGK- 143

  Fly   175 VAKIADNRILGAYALTEISHGTNALGMRTRATYDVKRQEFIIHTPDFEAAKCWVGNLGKTCTHAI 239
                 :.:|:..||.||:.|||...|:.|.||||...|||:||:|...:.|.|.|:||:|.|||:
Mouse   144 -----NFQIITTYAQTELGHGTYLQGLETEATYDATTQEFVIHSPTMTSIKWWPGDLGRTVTHAV 203

  Fly   240 VYAQLYVPDDKHQGLQAFLVPIRDERTLLPFPGVTVGDMGEKIGLNGIDNGFVMFNQYRIPKANL 304
            |.|.|.....:| |:.||:||||......|.||:||||:|.|:|...|||||:..|..|:|:.|:
Mouse   204 VLAHLICLGARH-GMHAFIVPIRSLEDHTPLPGITVGDIGPKMGFENIDNGFLRLNHVRVPRENM 267

  Fly   305 LSKTGDIDAQGNYTSKIKDERKRLGAS----LGALSVGRVNITAITYV-ALSKAVTIATRYAASR 364
            ||:..::...|.|        :|||..    ||.| |.||.:....:: .|.||.|||.|||..|
Mouse   268 LSRFAEVLPDGTY--------QRLGTPQSNYLGML-VTRVQLLYKGFLPTLQKACTIAVRYAVIR 323

  Fly   365 RQFGPTNSPAEWPVIEYQSQQYRLIPHLATTIALRVATL----WIGKENVDLTMKGFTGEDTSQA 425
            .|.....|..|..::|||:||.:|:|.||.:.||...|.    :......|:..:.|:      .
Mouse   324 HQSRLRPSDPEAKILEYQTQQQKLLPQLAVSYALHFMTTSLLQFFHSSYSDILKRDFS------L 382

  Fly   426 GMEIHAISSALKPVATWAARDGIQECREACGGHGYLKSSGLGELRNDNDANCTYEGENNTLIQQA 490
            ..|:||:|:.:|.:::.....|.:.||.|||||||.|.|||..|.....|:|||||||..|..|.
Mouse   383 LPELHALSTGMKAMSSDFCAQGTEICRRACGGHGYSKLSGLPTLVTQAIASCTYEGENTVLYLQV 447

  Fly   491 SNWLIS--LQRN-NADFVAVSPL-ETVSFLKDMDTILQSKGQERTPAEVLDPLNLLNALNWLTVW 551
            :.:|:.  ||.. :...:...|| ::|.:|.   |...::...:|.|:...|.....|..:::..
Mouse   448 ARFLMKSYLQAQVSPGSIPQKPLPQSVMYLA---TPRPARCPAQTAADFRCPEVYTTAWAYVSAR 509

  Fly   552 QLDTTVKRVEEQQREGKDAFETRNNIQVFAAQKLSIIYGERTIYYVFYKFVIGLPDSAEK----- 611
            .:....:..:...|.|.|.::..|        :.|:|:.:....:.::..|....::.||
Mouse   510 LIRDATQHTQTLMRSGVDQYDAWN--------QTSVIHLQAAKAHCYFLTVRNFKEAVEKLDNEP 566

  Fly   612 ---KVLQQVLSFYGAHLVTKYSAAFYRGGYFRENSNQLELYEQGILALLPLLKNEAIALVDAIAP 673
               :|||.:...|..:.:...|..|...|:.  :..|:::.....|.||||::.:||.|.||...
Mouse   567 EIQRVLQNLCDLYALNGILTNSGDFLHDGFL--SGAQVDMARTAFLDLLPLIRKDAILLTDAFDF 629

  Fly   674 TDFILNSPLGMSDGNVYQHLQRTLVSTP-GVYERPHWWRDVTYKDYLK 720
            :|..|||.||..||:|||.|......:| ...|.|      .||.|::
Mouse   630 SDHCLNSALGCYDGHVYQRLFEWAQKSPANTQENP------AYKKYIR 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9527	NP_001137800.1	ACAD	52..694	CDD:299127	210/690 (30%)
CG9527	NP_001137800.1	PLN02312	56..682	CDD:215178	203/674 (30%)
Acox2	NP_001155139.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		9/51 (18%)
		AXO	20..655	CDD:173839	213/700 (30%)
		Microbody targeting signal. /evidence=ECO:0000255	679..681
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810