DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9527 and ACOX1

DIOPT Version :9

Sequence 1:	NP_001137800.1	Gene:	CG9527 / 33898	FlyBaseID:	FBgn0031813	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_004026.2	Gene:	ACOX1 / 51	HGNCID:	119	Length:	660	Species:	Homo sapiens

Alignment Length:	688	Identity:	206/688 - (29%)
Similarity:	330/688 - (47%)	Gaps:	83/688 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PDFRSGPLEEYRERASFCYKRMNVVLEGE-DHIRLKHKVWQWMEQHPDYQREPGSDLERTR--EM 108
            ||.|     ..|:.|||..:.:..:|:|. :..|.:.::...:...||:|.|..:.|.|::  |:
Human     3 PDLR-----RERDSASFNPELLTHILDGSPEKTRRRREIENMILNDPDFQHEDLNFLTRSQRYEV 62

  Fly   109 ANKR----------------QHLLWEQQFYGVNEYLGTPHLLLAFGQAIFSYDFSTSVKFGLSTG 157
            |.::                ..::|.:.|.    :.|.|..|                  .|..|
Human    63 AVRKSAIMVKKMREFGIADPDEIMWFKNFV----HRGRPEPL------------------DLHLG 105

  Fly   158 MFPSTLVSNGSGRLGKYVAKIADN-RILGAYALTEISHGTNALGMRTRATYDVKRQEFIIHTPDF 221
            ||..||:...:....:.....|.| .|:|.||.||:.|||:..|:.|.||||.:.||||:::|..
Human   106 MFLPTLLHQATAEQQERFFMPAWNLEIIGTYAQTEMGHGTHLRGLETTATYDPETQEFILNSPTV 170

  Fly   222 EAAKCWVGNLGKTCTHAIVYAQLYVPDDKHQGLQAFLVPIRDERTLLPFPGVTVGDMGEKIGLNG 286
            .:.|.|.|.||||..||||.||| :...|..||.||:||||:..|..|.||:||||:|.|.|.:.
Human   171 TSIKWWPGGLGKTSNHAIVLAQL-ITKGKCYGLHAFIVPIREIGTHKPLPGITVGDIGPKFGYDE 234

  Fly   287 IDNGFVMFNQYRIPKANLLSKTGDIDAQGNYTSKIKDERKRLGASLGALSVGRVNITAITYVALS 351
            ||||::..:.:|||:.|:|.|...:...|.|...:.::     .:.|.:...|..:......|||
Human   235 IDNGYLKMDNHRIPRENMLMKYAQVKPDGTYVKPLSNK-----LTYGTMVFVRSFLVGEAARALS 294

  Fly   352 KAVTIATRYAASRRQFGPTNSPAEWPVIEYQSQQYRLIPHLATTIALRVATLWIGKENVDLTMKG 416
            ||.|||.||:|.|.|........|..::::|:|||:|.|.|||..|.:....:: ||......:|
Human   295 KACTIAIRYSAVRHQSEIKPGEPEPQILDFQTQQYKLFPLLATAYAFQFVGAYM-KETYHRINEG 358

  Fly   417 FTGEDTSQAGMEIHAISSALKPVATWAARDGIQECREACGGHGYLKSSGLGELRNDNDANCTYEG 481
            ....|.|:. .|:||:::.||...:|.|..||:.||.|||||||...|||..:..:...:||:||
Human   359 IGQGDLSEL-PELHALTAGLKAFTSWTANTGIEACRMACGGHGYSHCSGLPNIYVNFTPSCTFEG 422

  Fly   482 ENNTLIQQASNWLISL--QRNNADFVAVSPLETVSFLKDMDTILQSKGQERTPAEVL-------- 536
            ||..::.|.:.:|:..  |.::...|.    ..||:|.|:.:      |...|.:|.
Human   423 ENTVMMLQTARFLMKSYDQVHSGKLVC----GMVSYLNDLPS------QRIQPQQVAVWPTMVDI 477

  Fly   537 -DPLNLLNALNWLTVWQLDTTVKRVEEQ--QREGKDAFETRNNIQVFAAQKLSIIYGERTIYYVF 598
             .|.:|..|........::...|.::::  .|:.|:......::.:..|.:....|   .:..:|
Human   478 NSPESLTEAYKLRAARLVEIAAKNLQKEVIHRKSKEVAWNLTSVDLVRASEAHCHY---VVVKLF 539

  Fly   599 YKFVIGLPDSAEKKVLQQVLSFYGAHLVTKYSAAFYRGGYFRENSNQLELYEQGILALLPLLKNE 663
            .:.::.:.|.|.:.||:.:...|..:.:::.:..|.:|....|  .|:....|.:..||.|::::
Human   540 SEKLLKIQDKAIQAVLRSLCLLYSLYGISQNAGDFLQGSIMTE--PQITQVNQRVKELLTLIRSD 602

  Fly   664 AIALVDAIAPTDFILNSPLGMSDGNVYQHLQRTLVSTP 701
            |:|||||....|..|.|.||..|||||::|.....::|
Human   603 AVALVDAFDFQDVTLGSVLGRYDGNVYENLFEWAKNSP 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9527	NP_001137800.1	ACAD	52..694	CDD:299127	201/674 (30%)
CG9527	NP_001137800.1	PLN02312	56..682	CDD:215178	194/658 (29%)
ACOX1	NP_004026.2	AXO	3..637	CDD:173839	205/683 (30%)
ACOX1	NP_004026.2	PLN02443	5..651	CDD:178062	204/686 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810