DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9527 and Acox2

DIOPT Version :9

Sequence 1:	NP_001137800.1	Gene:	CG9527 / 33898	FlyBaseID:	FBgn0031813	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_665713.2	Gene:	Acox2 / 252898	RGDID:	628684	Length:	681	Species:	Rattus norvegicus

Alignment Length:	740	Identity:	222/740 - (30%)
Similarity:	338/740 - (45%)	Gaps:	118/740 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ALGDYYSGRREEKAAANIYDDKRIFPDFRSGPLEEYRERASFCYKRMNVVLEGE-DHIRLKHKVW 85
            :|||.:|.              ::.||     ::..|...||..:|:..:|:|. .:..|:.||.
  Rat     9 SLGDTWSW--------------QVHPD-----IDSERHSPSFSVERLTNILDGGLPNTVLRRKVE 54

  Fly    86 QWMEQHPDYQ--------REPGSDLERTREMANKRQH---LLWE--------QQFYGVNEYLGTP 131
            ..::..|.:.        ||     |...:...||.|   |.|.        ::.|......|..
  Rat    55 SIIQSDPVFNLKKLYFMTRE-----ELYEDAIQKRFHLEKLAWSLGWSEDGPERIYANRVLDGNV 114

  Fly   132 HLLLAFGQAIFSYDFSTSVKFGLSTGMFPSTLVSNGSG-RLGKYVAKIADNRILGAYALTEISHG 195
            :|.|                    .|:..:.:.|.||. ::.|:.....:.:|:..||.||:.||
  Rat   115 NLSL--------------------HGVAMNAIRSLGSDEQIAKWGQLCKNFQIITTYAQTELGHG 159

  Fly   196 TNALGMRTRATYDVKRQEFIIHTPDFEAAKCWVGNLGKTCTHAIVYAQLYVPDDKHQGLQAFLVP 260
            |...|:.|.||||..||||:||:|...:.|.|.|:||.:.|||:|.|||.....:| |:.||:||
  Rat   160 TYLQGLETEATYDEARQEFVIHSPTMTSTKWWPGDLGWSVTHAVVLAQLTCLGVRH-GMHAFIVP 223

  Fly   261 IRDERTLLPFPGVTVGDMGEKIGLNGIDNGFVMFNQYRIPKANLLSKTGDIDAQGNYTSKIKDER 325
            ||......|.||:||||:|.|:||..|||||:..|..|:|:.|:||:..::...|.|
  Rat   224 IRSLEDHTPLPGITVGDIGPKMGLEHIDNGFLQLNHVRVPRENMLSRFAEVLPDGTY-------- 280

  Fly   326 KRLGAS----LGALSVGRVNITAITYV-ALSKAVTIATRYAASRRQFGPTNSPAEWPVIEYQSQQ 385
            :|||..    ||.| |.||.:.....: :|.||..|||||:..|.|.....|..|..::|||:||
  Rat   281 QRLGTPQSNYLGML-VTRVQLLCKGILPSLQKACIIATRYSVIRHQSRLRPSDPEAKILEYQTQQ 344

  Fly   386 YRLIPHLATTIALRVATLWIGKENVDLTMKGFTGEDTSQAGMEIHAISSALKPVATWA--ARDGI 448
            .:|:|.||.:.|.......: .|....:.......|.|.. .|:||:|:.:|  ||:|  ...|.
  Rat   345 QKLLPQLAVSYAFHFTATSL-SEFFHSSYSAILKRDFSLL-PELHALSTGMK--ATFADFCAQGA 405

  Fly   449 QECREACGGHGYLKSSGLGELRNDNDANCTYEGENNTLIQQASNWLIS--LQ-RNNADFVAVSPL 510
            :.||.|||||||.|.|||..|.....|:|||||||..|..|.:.:|:.  || :.:.......||
  Rat   406 EICRRACGGHGYSKLSGLPTLVARATASCTYEGENTVLYLQVARFLMKSYLQAQASPGATPQKPL 470

  Fly   511 -ETVSFLKDMDTILQSKGQERTPAEVLDPLNLLNALNWLTVWQLDTTVKRVEEQQREGKDAFETR 574
             ::|.::.   |...::...:|.|:...|.....|..:::...:.....|.:...:.|.|..:..
  Rat   471 PQSVMYIA---TQRPARCSAQTAADFRCPDVYTTAWAYVSTRLIRDAAHRTQTLMKSGVDQHDAW 532

  Fly   575 NNIQVFAAQKLSIIYGERTIYYVFYKFVIGLPDSAEK--------KVLQQVLSFYGAHLVTKYSA 631
            |        :.::|:.:....|.::..|....::.||        :|||::...|..|.|...|.
  Rat   533 N--------QTTVIHLQAAKAYCYFITVKNFKEAVEKLDKEPEIQRVLQRLCDLYALHGVLTNSG 589

  Fly   632 AFYRGGYFRENSNQLELYEQGILALLPLLKNEAIALVDAIAPTDFILNSPLGMSDGNVYQHLQRT 696
            .|...|:.  :..|:::..:..|.||||::.:||.|.||...:|..|||.||..||:||:.|...
  Rat   590 DFLHDGFL--SGAQVDMAREAFLDLLPLIRKDAILLTDAFDFSDHCLNSALGCYDGHVYERLFEW 652

  Fly   697 LVSTP-GVYERPHWWRDVTYKDYLK 720
            ...:| ...|.|      .||.|::
  Rat   653 AQKSPANTQENP------AYKKYIR 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9527	NP_001137800.1	ACAD	52..694	CDD:299127	209/681 (31%)
CG9527	NP_001137800.1	PLN02312	56..682	CDD:215178	203/665 (31%)
Acox2	NP_665713.2	AXO	20..655	CDD:173839	212/691 (31%)
Acox2	NP_665713.2	Microbody targeting signal. /evidence=ECO:0000255	679..681
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810