DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9527 and acox-1.2

DIOPT Version :9

Sequence 1:	NP_001137800.1	Gene:	CG9527 / 33898	FlyBaseID:	FBgn0031813	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_493262.2	Gene:	acox-1.2 / 173163	WormBaseID:	WBGene00008565	Length:	661	Species:	Caenorhabditis elegans

Alignment Length:	710	Identity:	202/710 - (28%)
Similarity:	319/710 - (44%)	Gaps:	147/710 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LEEYRERASFCYKRMNVVLEG-EDHIRLKHKVWQWMEQHPDYQREPGSDL-------------ER 104
            |.|.|..|:|...:|..|:.| |:..|.:.::...:.:.|:.     :|:             |.
Worm    14 LLEERRMATFDTDKMAAVIYGSEEFARRRREITDAVSKIPEL-----ADIKPYPFLTREEKVTEG 73

  Fly   105 TREMA-------------NKRQHLLWEQQFYGVNEYLGTPHLLLAFGQAIFSYDFSTSVKFGLST 156
            ||:::             |:.:.|...::..|   |.|.|                    |.|..
Worm    74 TRKISILTKYLNQLIDRDNEEESLHLHREVIG---YEGHP--------------------FALHD 115

  Fly   157 GMFPSTLVSNGSG-RLGKYVAKIADNRILGAYALTEISHGTNALGMRTRATYDVKRQEFIIHTPD 220
            .:|..||.|..|. :..|::.:.....|:|.||.||:.||:|...:.|.|.||:..|||::|||.
Worm   116 ALFIPTLQSQASDEQQEKWLERARRREIIGCYAQTELGHGSNLRNLETTAVYDIASQEFVLHTPT 180

  Fly   221 FEAAKCWVGNLGKTCTHAIVYAQLYVPDDKHQGLQAFLVPIRDERTLLPFPGVTVGDMGEKIGLN 285
            ..|.|.|.|.|||:|.:|:|.|:|.:..:.: |...|:|.:|||:|.:|..||||||:|.|:..|
Worm   181 TTALKWWPGALGKSCNYALVVAELIIKRNNY-GPHFFMVQLRDEKTHIPLKGVTVGDIGPKMNFN 244

  Fly   286 GIDNGFVMFNQYRIPKANLLSKTGDIDAQGNYTSKIKDERKRLGASLGALSVGRVNITAITYVAL 350
            ..|||::..|..|:|:.|||.:...::|.|.|   :|....::|.| |.:.: |..:.....:.|
Worm   245 AADNGYLGLNNLRVPRTNLLMRHCKVEADGTY---VKPPHAKIGYS-GMVKI-RSQMAMEQGLFL 304

  Fly   351 SKAVTIATRYAASRRQFGPTNSPAEWPVIEYQSQQYRLIPHLATTIALRVATLWIGKENVDL--- 412
            :.|:|||.||:|.|||....:...|..|::||:||:||.|.||...|.    ::.|.|.:.|
Worm   305 AHALTIAARYSAVRRQGHLDDKQVEVKVLDYQTQQHRLFPSLARAYAF----IFTGFETIHLYSQ 365

  Fly   413 TMKGFTGEDTSQAGM-EIHAISSALKPVATWAARDGIQECREACGGHGYLKSSGLGELRNDNDAN 476
            .:|.....:||  || ::||::|.||.|......:||::.|.|||||||..:|.:..:.......
Worm   366 LLKDVDMGNTS--GMADLHALTSGLKSVVAHETGEGIEQARMACGGHGYSMASYISVVYGIAIGG 428

  Fly   477 CTYEGENNTLIQQASNWLISLQRNNADFVAVSPLETVSFLKDMDTILQSKGQERTP-----AEVL 536
            |||||||..::.|.:.:|:                     |.::.|...|.::..|     |:..
Worm   429 CTYEGENMVMLLQLARYLV---------------------KSVELIKAGKAKKLGPVASYLADKS 472

  Fly   537 DPLNLLNALNWLTVWQLDTTVKRVEEQQR--------------EGKDAFETRNNIQVFAAQKLSI 587
            |..:|.:         |:..||..|...|              |..::.|...|.......:.|.
Worm   473 DETDLTS---------LNGYVKMFENMARRQAWKATEKFLKLMESGESREVAWNKSAVELTRASR 528

  Fly   588 IYGERTIYYVFYKFVIGLPDSAEKKVLQQVLSFYGAHLVTKYS-----------AAFYRGGYFRE 641
            ::....|...|.:.|..:.|...|:||..:|     ||...|.           .:|.:..|.|:
Worm   529 LHTRLFIIEAFMRRVSRIEDIPVKEVLTDLL-----HLHVNYELLDVATYALEFMSFTQLDYVRD 588

  Fly   642 NSNQLELYEQGILALLPLLKNEAIALVDAIAPTDFILNSPLGMSDGNVYQHLQRTLVSTP 701
               ||.||       |..::..|::|||:...:|..|.|.||..||:||::|.:...|:|
Worm   589 ---QLYLY-------LEKIRPNAVSLVDSFQISDMQLRSVLGRRDGHVYENLFKWAKSSP 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9527	NP_001137800.1	ACAD	52..694	CDD:299127	199/701 (28%)
CG9527	NP_001137800.1	PLN02312	56..682	CDD:215178	192/687 (28%)
acox-1.2	NP_493262.2	ACAD	12..635	CDD:299127	200/705 (28%)
acox-1.2	NP_493262.2	PLN02443	14..658	CDD:178062	202/710 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810