Protein Alignment Nepl6 and ECEL1

DIOPT Version :9

• Sequence 1: NP_609023.3
• Gene: Nepl6 / 33893
• FlyBaseID: FBgn0259716
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_004817.2
• Gene: ECEL1 / 9427
• HGNCID: 3147
• Length: 775
• Species: Homo sapiens
• Alignment Length: 785
• Identity: 175/785 - (22%)
• Similarity: 294/785 - (37%)
• Gaps: 220/785 - (28%)

  Fly     3 LIACLFIVPIC----AAPTTQNVEADPNSRLMNNILSYVAEDSSA----CGTYFQYACGKYAVRH 59
            ::|..::.|:.    |.|     |..|..:.......::|.:..|    |..::.:|||.:..||
Human    79 MLALKYLGPVAAGGGACP-----EGCPERKAFARAARFLAANLDASIDPCQDFYSFACGGWLRRH 138

  Fly    60 R--DDPFT-EIIQMLDHKVNGNLVQLMHELHQRSQSPGFNESSVEAKVLHFYRTCREAPPSTRKM 121
            .  ||..| ..|..:..:   |..:|...|.:....||   .:.:.||..|:|:|.:    .|::
Human   139 AIPDDKLTYGTIAAIGEQ---NEERLRRLLARPGGGPG---GAAQRKVRAFFRSCLD----MREI 193

  Fly   122 EHYLRLAP---------------------PGQALTWPQFMPRGEPWPKAQFKWMKSLGHLYR--- 162
            |   ||.|                     ||.|..|.                :..|  ||:
Human   194 E---RLGPRPMLEVIEDCGGWDLGGAEERPGVAARWD----------------LNRL--LYKAQG 237

  Fly   163 -YGFTNVLVNVLVLRSSENSNRF--RLD---ISMP------SLEGDAQHLGGFLSTLATLQIIGV 215
             |. ...|.::.|.....||:|:  |:|   :::|      :.:.|::.:      ||..::...
Human   238 VYS-AAALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEDSEKI------LAAYRVFME 295

  Fly   216 PTKSIL------PLVRKIRRLESAIRVLTEVDDD----DESETW---TLRQWEYKTGY-AWQGFV 266
            ...|:|      ...::|.::|..:..:|..:.|    |.|..:   ||.|.:..|.: .|:..:
Human   296 RVLSLLGADAVEQKAQEILQVEQQLANITVSEHDDLRRDVSSMYNKVTLGQLQKITPHLRWKWLL 360

  Fly   267 ESIVGHSVSHHYVMQAQNAKYFTGLKRLMDSTDAEVVANYIMTRFVLYLIDDFIDSNEHID---- 327
            :.|.....|....:......|...:.:|:.||...|:.||::.|.|:.|       :||:.
Human   361 DQIFQEDFSEEEEVVLLATDYMQQVSQLIRSTPHRVLHNYLVWRVVVVL-------SEHLSPPFR 418

  Fly   328 ----------------------CVTDMRRNMNLASNLLY-KERF--LDPATLQQYTQEVTKVFEQ 367
                                  |:....|:..:|...|: .|.|  ...|.:||..:::
Human   419 EALHELAQEMEGSDKPQELARVCLGQANRHFGMALGALFVHEHFSAASKAKVQQLVEDI------ 477

  Fly   368 LRRQFLLQINENRLGLTSEQNSMVATKAQHVVLNIGNLPRGRDHRSF------VSRHYEDLVFPL 426
              :..|.|..|....:.:|..:....|.|::::.:|       :..|      |.:.||   |.:
Human   478 --KYILGQRLEELDWMDAETRAAARAKLQYMMVMVG-------YPDFLLKPDAVDKEYE---FEV 530

  Fly   427 PDFDYAREHLNLLEFRTRKQVLQLNQSAPTPDEFFYLSDPKTAMSSGPYYLMRLNIIVVPHGLLQ 491
            .:..|.:..||.:.|..:..|.::.|..   |:..:|..|: |:::  |||...|.:|.|.|:||
Human   531 HEKTYFKNILNSIRFSIQLSVKKIRQEV---DKSTWLLPPQ-ALNA--YYLPNKNQMVFPAGILQ 589

  Fly   492 EPFFAADSHDIFKYSLLGFVLAHELMHSVDTVGLYYDRYGNIHEIGPQISSSPRFVAGLQCLNR- 555
            ...:..|......|..:|.::.|||.|..|..|..|||.||:.....:.|.| ||:...:|:.|
Human   590 PTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTEASYS-RFLRKAECIVRL 653

  Fly   556 --NSTQY---------LDERIADIAGLDLAYSTYFQNSSQMSLTDFTTIPP--------QQIFFL 601
              |.|.|         |.|.|||:.||.|||..|     |..:.:.....|        .|:||:
Human   654 YDNFTVYNQRVNGKHTLGENIADMGGLKLAYHAY-----QKWVREHGPEHPLPRLKYTHDQLFFI 713

  Fly   602 NLAQFFCGDGDPINFVGHDNDETRLQQMLNGFAPFH--------------EAFGCPAKS--NQPE 650
            ..||.:|        :...:....||.:.:..||.|              .||.||..|  |...
Human   714 AFAQNWC--------IKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNPAH 770

  Fly   651 KCQLW 655
            ||.:|
Human   771 KCSVW 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	42..653	CDD:189000	166/738 (22%)
ECEL1	NP_004817.2	M13	120..773	CDD:341056	165/735 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910