DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl6 and Ece1

DIOPT Version :9

Sequence 1:	NP_609023.3	Gene:	Nepl6 / 33893	FlyBaseID:	FBgn0259716	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_006239337.1	Gene:	Ece1 / 94204	RGDID:	620293	Length:	769	Species:	Rattus norvegicus

Alignment Length:	759	Identity:	184/759 - (24%)
Similarity:	290/759 - (38%)	Gaps:	174/759 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LIACLFIV---------PICAAPTTQNVEADPNSRLMNNILSYVAEDSSACGTYFQYACGKYAVR 58
            |:|||..:         |:|......:|        .::||:.:......|..:|.||||.:.
  Rat    79 LVACLAALGIQYRTRTPPVCLTEACVSV--------TSSILNSMDPTVDPCQDFFSYACGGWI-- 133

  Fly    59 HRDDPFTE-------IIQMLDHKVNGNLVQLMHELHQRSQSPGFNESSVEAKVLHFYRTCREAPP 116
             :.:|..:       ...:.:|    |...:.|.|...:.|    .|..|.|...:||.|..
  Rat   134 -KANPVPDGHSRWGTFSNLWEH----NQAIIKHLLENSTAS----ASEAEKKAQVYYRACMN--- 186

  Fly   117 STRKMEHYLRLAP--------PGQALTWPQFMPRGEPWPKAQFK-WMKSLGHLYRYGFTNVLVNV 172
            .||..|  ||..|        .|..:|        .||.|..|: .::.:...||   |:...:|
  Rat   187 ETRIEE--LRAKPLMELIEKLGGWNIT--------GPWAKDNFQDTLQVVTAHYR---TSPFFSV 238

  Fly   173 LVLRSSENSNR--FRLD---ISMPSLE------GDAQHLGGFLSTLATLQII--GVPTKSILPLV 224
            .|...|:|||.  .::|   :.:||.:      .:.:.|.|:|:.:..|..:  |....||.|.:
  Rat   239 YVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEDSIRPQM 303

  Fly   225 RKIRRLESAIRVLT---EVDDDDESETWTLRQWEYKT---GYAWQGFVESI---VGHSVSHHYVM 280
            ::|...|:|:..:|   |...|:|.....:...|.:|   ...|..|:.:|   |..:.|...|:
  Rat   304 QQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNAIFYPVEINESEPIVV 368

  Fly   281 QAQNAKYFTGLKRLMDSTDAEVVANYIMTRFV----LYLIDDFIDSNEHI--------------- 326
              .:.:|...:..|::|||..::.||:|...|    .:|...|.|::|..
  Rat   369 --YDKEYLRQVSTLINSTDKCLLNNYMMWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRW 431

  Fly   327 -DCVTDMRRNMNLASNLLY-KERFLDPA--TLQQYTQEVTKVFEQLRRQFLLQINENRLGLTSEQ 387
             .||:|...|:..|...:: |..|.:.:  ...:...|:.|.||:         :.:.|....|.
  Rat   432 KFCVSDTENNLGFALGPMFVKATFAEDSKNIASEIILEIKKAFEE---------SLSTLKWMDED 487

  Fly   388 NSMVATKAQHVVLNIGNLPRGRDHRSFVSRHYE-DLVF----PLPDFDYAREHLNLLEFRTRKQV 447
            ....|.:....:.|:...|      :|:....| |.||    .:||. |....:....|..|...
  Rat   488 TRRSAKEKADAIYNMIGYP------NFIMDPKELDKVFNDYTAVPDL-YFENAMRFFNFSWRVTA 545

  Fly   448 LQLNQSAPTPDEFFYLSDPKTAMSSGPYYLMRLNIIVVPHGLLQEPFFAADSHDIFKYSLLGFVL 512
            .|| :.||..|::     ..|......||....|.||.|.|:||.||:...|.:...:..:|.|:
  Rat   546 DQL-RKAPNRDQW-----SMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVV 604

  Fly   513 AHELMHSVDTVGLYYDRYGNIHEIGP--QISSSPRFVAGLQCLNRNSTQY------------LDE 563
            .|||.|:.|..|..||:.||:.   |  :.||...|....:|:.:....|            |.|
  Rat   605 GHELTHAFDDQGREYDKDGNLR---PWWKNSSVEAFKQQTECMVQQYNNYSVNGEPVNGRHTLGE 666

  Fly   564 RIADIAGLDLAYSTY----FQNSSQMSLTDFTTIPPQQIFFLNLAQFFCG--------DG---DP 613
            .|||..||..||..|    .:|.::..|... .:...|:|||..||.:|.        :|   ||
  Rat   667 NIADNGGLKAAYRAYQNWVKKNGAEQILPTL-GLTSNQLFFLGFAQVWCSVRTPESSHEGLITDP 730

  Fly   614 INFVGHDNDETRLQQMLNGFAPFHEAFGCPAKS--NQPEKCQLW 655
                 |.....|:...|:....|.|.|.||..|  |...||::|
  Rat   731 -----HSPSRFRVIGSLSNSKEFSEHFRCPLGSPMNPRHKCEVW 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	42..653	CDD:189000	173/707 (24%)
Ece1	XP_006239337.1	PepO	105..769	CDD:226118	177/731 (24%)
Ece1	XP_006239337.1	M13	118..767	CDD:189000	173/708 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910