DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl6 and ece2b

DIOPT Version :9

Sequence 1:	NP_609023.3	Gene:	Nepl6 / 33893	FlyBaseID:	FBgn0259716	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_017206531.1	Gene:	ece2b / 793465	ZFINID:	ZDB-GENE-131120-140	Length:	794	Species:	Danio rerio

Alignment Length:	766	Identity:	173/766 - (22%)
Similarity:	286/766 - (37%)	Gaps:	152/766 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LIACLFIVPICAAPTTQNVEADPNSRL---------MNNILSYVAEDSSACGTYFQYACGKYA-- 56
            |:|.|..:..||.........||...:         .:.|:..:...:..|..::|||||.:.
Zfish    68 LLASLLALFGCAVTLGVRYNRDPARSICLTEACVTVASKIVEALDRSADPCQDFYQYACGGWVRK 132

  Fly    57 -----VRHRDDPFTEIIQMLDHKVNGNLVQLMHELHQRSQSPGFNESS-VEAKVLHFYRTCREAP 115
                 .|.|...|..|...       |...|.|.|    ::..||.|| .|.|...:|.:|.
Zfish   133 NPLPDGRSRWSTFNSIWDQ-------NQAVLKHLL----ENGTFNSSSEAERKTQSYYLSCL--- 183

  Fly   116 PSTRKMEHYLRLAPPGQALTWPQFMPRGEPWPKAQF-KWMKSLGHLYRYG--FTNVLVNVLVLRS 177
             :.:::|. |...|....:|........|.|.|..| ..:|.:...||..  ||   |:|.|...
Zfish   184 -NEQRIEE-LGAQPLMDLITKIGGWNITESWDKENFLDVLKIISGPYRAQPFFT---VSVSVDPK 243

  Fly   178 SENSNRFRLDIS---MPSLE-----GDAQHLGGFLSTLATL-QIIGVPTKSILPLVRKIRRLESA 233
            :.|||..::|.|   :||.:     .:.:.|..:|..:..| .::|....|....:::|...|:|
Zfish   244 NSNSNVIQVDQSGLFLPSRDYYLNKTNEKVLKAYLDYMVELGLLLGGDKNSTRGQMQQILDFETA 308

  Fly   234 IRVLTEVDDD--DESETW---TLRQWE-YKTGYAWQGFVESIVGH---SVSHHYVMQAQNAKYFT 289
            :..:|...|:  ||.:.:   |:...: ......|..::.|::..   :.:...|:.|:  :|..
Zfish   309 LANITVPQDERRDEEKIYHKITIADLQVLAPAIEWLDYLNSVLSPLELNDTEPVVVYAK--EYMQ 371

  Fly   290 GLKRLMDSTDAEVVANYIMTRFV----LYLIDDFIDSNEHI----------------DCVTDMRR 334
            .:..|::.||..::.||::...|    ..|...|.::.:.:                .|:.:...
Zfish   372 QVSELINKTDHSLLNNYMIWNLVQKGASSLDQRFENAQDKLLESLYGTKKSCTPRWQTCIGNTDD 436

  Fly   335 NMNLASNLLYKERFLDP----------ATLQQYTQEVTKVFEQLRRQFLLQ----INENR----- 380
            .:..|...|:.:...|.          |.|....:.|......|....:.|    |||.|
Zfish   437 TLGFALGALFVKATFDKQSKEIDLNGGAFLPSCGRNVNSTVHNLMFSVITQAEGMINEIRTAFKG 501

  Fly   381 ----LGLTSEQNSMVATKAQHVVLNIGNLPRGRDHRSFV--SRHYEDLV--FPLPDFDYAREHLN 437
                |....||....|......:.::...|      .|:  |:..:|:.  :.:.:.::.:..:|
Zfish   502 ALDDLKWMDEQTRQAAKDKADAIYDMIGFP------DFILDSKELDDVYDGYEVTEDNFFQNMIN 560

  Fly   438 LLEFRTRKQVLQLNQSAPTPDEFFYLSDPKTAMSSGPYYLMRLNIIVVPHGLLQEPFFAADSHDI 502
            ...|..|....|| :..|..|::     ..|..:...||:...|.||.|.|:||.||:|.|....
Zfish   561 FYNFSARVMADQL-RKPPNRDQW-----SMTPPTVNAYYMPTKNGIVFPAGILQAPFYAQDHPKA 619

  Fly   503 FKYSLLGFVLAHELMHSVDTVGLYYDRYGNIHEIGPQISSSPRFVAGLQCLNRNSTQY------- 560
            ..:..:|.|:.|||.|:.|..|..||:.||:.... |.||...|....:|:....|||
Zfish   620 LNFGGIGVVMGHELTHAFDDQGREYDKDGNLRSWW-QNSSVEAFKNRTECMVDQYTQYTINGEHI 683

  Fly   561 -----LDERIADIAGLDLAYSTY---FQNSSQMSLTDFTTIPPQQIFFLNLAQFFCG-------- 609
                 |.|.|||..||..||..|   .|.:.:........:...|:||:..||.:|.
Zfish   684 NGKQTLGENIADNGGLKAAYHAYRSWVQKNGEEKRLPAVNLTNDQLFFVGFAQVWCSVRTPESAH 748

  Fly   610 DG---DPINFVGHDNDETRLQQMLNGFAPFHEAFGCPAKS--NQPEKCQLW 655
            :|   ||     |...:.|:...|:....|.|.|.||..|  |...:|::|
Zfish   749 EGLMTDP-----HSPPKYRVIGTLSNSPEFAEHFQCPLGSSMNSGHRCEVW 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	42..653	CDD:189000	163/714 (23%)
ece2b	XP_017206531.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010