Protein Alignment Nepl6 and MMEL1

DIOPT Version :10

• Sequence 1: NP_609023.3
• Gene: Nepl6 / 33893
• FlyBaseID: FBgn0259716
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_258428.2
• Gene: MMEL1 / 79258
• HGNCID: 14668
• Length: 779
• Species: Homo sapiens
• Alignment Length: 760
• Identity: 166/760 - (21%)
• Similarity: 283/760 - (37%)
• Gaps: 192/760 - (25%)

  Fly    12 ICAAPTTQNVEADPNSRLMNNILSYVAEDSSACGTYFQYACGKYAVRH---RDDPFTEIIQMLDH 73
            |.||...||:  ||.              :..|..::|:|||.:..||   ..:....|..:|..
Human    96 IAAARILQNM--DPT--------------TEPCDDFYQFACGGWLRRHVIPETNSRYSIFDVLRD 144

  Fly    74 KVNGNLVQLMHELHQRSQSPGFNESSVEAKVLHFYRTC--------REAPPSTRKMEHYLRLAPP 130
            ::...|..::      ..|...:..:|| |....||:|        |.:.|....:|
Human   145 ELEVILKAVL------ENSTAKDRPAVE-KARTLYRSCMNQSVIEKRGSQPLLDILE-------- 194

  Fly   131 GQALTWPQFMPRGEPWPKAQFKWMKSLG---------HLYRYGFT-NVLVNVLVLRSSENSNRFR 185
                     :..|  ||.|..:|.:::|         .|....|. .||:::.:....:||:|..
Human   195 ---------VVGG--WPVAMDRWNETVGLEWELERQLALMNSQFNRRVLIDLFIWNDDQNSSRHI 248

  Fly   186 LDISMPSLEGDAQHL---GG-----------FLSTLATL--QIIGVPTKSIL---PLVRKIRRLE 231
            :.|..|:|...::..   ||           |:.::|||  :...:|..|.|   .:| ::..||
Human   249 IYIDQPTLGMPSREYYFNGGSNRKVREAYLQFMVSVATLLREDANLPRDSCLVQEDMV-QVLELE 312

  Fly   232 SAIRVLTEVDDDDESETWTL----------RQWEYKTGYAWQGFVESIVGHSVSHHYVMQAQ--- 283
            :.:...| |..::..:...|          .|:..| |:.|..|:::::. ||....:...:
Human   313 TQLAKAT-VPQEERHDVIALYHRMGLEELQSQFGLK-GFNWTLFIQTVLS-SVKIKLLPDEEVVV 374

  Fly   284 -NAKYFTGLKRLMDSTDAEVVANYIMTRFVL-------------------YLIDDFIDSNEHIDC 328
             ...|...|:.::|:..|..:.||::.|.||                   .|....::.....:|
Human   375 YGIPYLQNLENIIDTYSARTIQNYLVWRLVLDRIGSLSQRFKDTRVNYRKALFGTMVEEVRWREC 439

  Fly   329 VTDMRRNM-NLASNLLYKERFLDPATLQQYTQEVTKVFEQLRRQFLLQINENRLGLTSEQNSMVA 392
            |..:..|| |...:|..:|.|  |...:...:|   :.:::|..|:..::|  ||...|::...|
Human   440 VGYVNSNMENAVGSLYVREAF--PGDSKSMVRE---LIDKVRTVFVETLDE--LGWMDEESKKKA 497

  Fly   393 -TKAQHVVLNIGNLPRGRDHRSFV--------SRHYEDLVFPLPDFDYAREHLNLLEFRTRKQVL 448
             .||..:...||       |..::        ...|.:|.|. .|. |....|..|:...::.:.
Human   498 QEKAMSIREQIG-------HPDYILEEMNRRLDEEYSNLNFS-EDL-YFENSLQNLKVGAQRSLR 553

  Fly   449 QLNQSAPTPDEFFYLSDPKT----AMSSGPYYLMRLNIIVVPHGLLQEPFFAADSHDIFKYSLLG 509
            :|.:..          ||..    |.....:|....|.||.|.|:||.|||:.:......:..:|
Human   554 KLREKV----------DPNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKEQPQALNFGGIG 608

  Fly   510 FVLAHELMHSVDTVGLYYDRYGNIHEIGPQISSSPRFVAGLQCL---------------NRNSTQ 559
            .|:.||:.|..|..|..:|:.||:.:.....|:. .|....:|:               |.|...
Human   609 MVIGHEITHGFDDNGRNFDKNGNMMDWWSNFSTQ-HFREQSECMIYQYGNYSWDLADEQNVNGFN 672

  Fly   560 YLDERIADIAGLDLAYSTYFQ------NSSQMSLTDFTTIPPQQIFFLNLAQFFCGDGDP----- 613
            .|.|.|||..|:..||..|.:      ...|:...|.|   .:|:||:|.||.:||...|
Human   673 TLGENIADNGGVRQAYKAYLKWMAEGGKDQQLPGLDLT---HEQLFFINYAQVWCGSYRPEFAIQ 734

  Fly   614 -INFVGHDNDETRLQQMLNGFAPFHEAFGCP--AKSNQPEKCQLW 655
             |....|...:.|:...|...|.|.:.|.|.  ...:..|:|::|
Human   735 SIKTDVHSPLKYRVLGSLQNLAAFADTFHCARGTPMHPKERCRVW 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	47..653	CDD:341056	156/721 (22%)
MMEL1	NP_258428.2	M13	111..777	CDD:341056	157/725 (22%)